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Amino Acids

, Volume 27, Issue 3–4, pp 335–337 | Cite as

Differential protein expression profile in gastrointestinal stromal tumors

  • B. Landuyt
  • H. Prenen
  • M. Debiec-Rychter
  • R. Sciot
  • E. A de Bruijn
  • A. T. van Oosterom
Short Communication

Summary.

Gastrointestinal stromal tumors (GISTs) arise from the interstitial cells of Cajal through gain of function mutations of the oncogene KIT. Imatinib offers the first effective treatment for patients with GISTs, but the therapeutic outcome strongly depends on the type of KIT mutation. We used ProteinChip technology to investigate whether GISTs with different KIT mutations express different proteins. In total, 154 proteins were significantly differentially expressed in GISTs with exon 9 KIT mutation compared to GISTs with exon 11 KIT mutation.

Keywords: GIST – KIT – Imatinib – SELDI TOF MS – ProteinChip 

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Copyright information

© Springer-Verlag/Wien 2004

Authors and Affiliations

  • B. Landuyt
    • 1
  • H. Prenen
    • 1
  • M. Debiec-Rychter
    • 2
  • R. Sciot
    • 3
  • E. A de Bruijn
    • 1
  • A. T. van Oosterom
    • 1
  1. 1.Laboratory of Experimental Oncology (LEO), University Hospital Gasthuisberg, Catholic University of LeuvenLeuvenBelgium
  2. 2.Laboratory for Cytogenetics and Molecular Genetics of Human Malignancies, Department for Human GeneticsCatholic University of LeuvenBelgium
  3. 3.Department of Pathology, University Hospital GasthuisbergCatholic University of LeuvenBelgium

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