Hexafluoroacetone as protecting and activating reagent: Site-selective functionalization of iminodiacetic acid
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Hexafluoroacetone was applied as a bidentate protecting and activating agent for the syntheses of RGD-peptide mimetics starting from iminodiacetic acid in solution and on solid phase.
Keywords: Iminodiacetic acid – Hexafluoroacetone – Integrins – Site selective functionalization – Solid phase synthesis – Wang resin – PEGA resin – Affinity labeling
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© Springer-Verlag/Wien 2004