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Amino Acids

, Volume 27, Issue 3–4, pp 285–290 | Cite as

Hexafluoroacetone as protecting and activating reagent: Site-selective functionalization of iminodiacetic acid

  • T. Rühl
  • C. Böttcher
  • L. Hennig
  • K. Burger
Article
  • 70 Downloads

Summary.

Hexafluoroacetone was applied as a bidentate protecting and activating agent for the syntheses of RGD-peptide mimetics starting from iminodiacetic acid in solution and on solid phase.

Keywords: Iminodiacetic acid – Hexafluoroacetone – Integrins – Site selective functionalization – Solid phase synthesis – Wang resin – PEGA resin – Affinity labeling 

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Copyright information

© Springer-Verlag/Wien 2004

Authors and Affiliations

  • T. Rühl
    • 1
  • C. Böttcher
    • 1
  • L. Hennig
    • 1
  • K. Burger
    • 1
  1. 1.Organisch-Chemisches Institut der Universität LeipzigLeipzigGermany

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