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Effects of ornithine on neutrophil (PMN) free amino acid and α-keto acid profiles and immune functions in vitro

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Summary.

The objective of this study was to determine the effects of ornithine on polymorphonuclear leucocyte (PMN) free amino- and α-keto acid profiles, superoxide anion (O2−) generation, hydrogen peroxide (H2O2) formation and released myeloperoxidase acitivity (MPO). Exogenous ornithine significantly increased PMN asparagine, glutamine, asparatate, glutamate, arginine, citrulline, alanine, α-ketoglutarate and pyruvate as intracellular ornithine increased. Concerning PMN immune function markers ornithine increased H2O2-generation and MPO acitivity while O2−-formation was decreased. We believe therefore that ornithine is important for affecting PMN “susceptible free amino- and α-keto acid pool” although the mechanisms are not yet clear. This may be one of the determinants in PMN nutrition considerably influencing and modulating PMN host defense capability.

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Authors and Affiliations

  1. Department of Anaesthesiology, Intensive Care Medicine, Pain Therapy, University Hospital, Justus Liebig University, Giessen, Germany

    J. Mühling, J. Gonter, J. Engel, I. D. Welters, M. Wolff, R. Matejec, M. G. Dehne, T. Menges & G. Hempelmann

  2. Dr. Ing. Herbert Knauer GmbH, Berlin, Germany

    M. Fuchs & M. Campos

  3. Clinics of Anaesthesiology and Intensive Care Medicine, Martin Luther University, Halle-Wittenberg, Germany

    A. Sablotzki

  4. Department of Internal Medicine/Infectious Diseases, Charité, Medical School of Humboldt University, Berlin, Germany

    M. Krüll

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  1. J. Mühling
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  2. M. Fuchs
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  3. M. Campos
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  4. J. Gonter
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  5. A. Sablotzki
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  6. J. Engel
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  7. I. D. Welters
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  8. M. Wolff
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  9. R. Matejec
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  10. M. G. Dehne
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  11. T. Menges
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  12. M. Krüll
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  13. G. Hempelmann
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Mühling, J., Fuchs, M., Campos, M. et al. Effects of ornithine on neutrophil (PMN) free amino acid and α-keto acid profiles and immune functions in vitro. Amino Acids 27, 313–319 (2004). https://doi.org/10.1007/s00726-004-0126-0

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  • DOI: https://doi.org/10.1007/s00726-004-0126-0

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