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Amino Acids

, Volume 26, Issue 1, pp 85–89 | Cite as

L-Histidine is a beneficial adjuvant for antiepileptic drugs against maximal electroshock-induced seizures in mice

  • R. M. Kamiński
  • D. Żółkowska
  • M. Kozicka
  • Z. Kleinrok
  • S. J. Czuczwar
Article

Summary.

Endogenous histamine has been reported to be involved in regulation of seizure susceptibility. Enhancement of histamine neurotransmission engendered by L-histidine treatment produces anticonvulsant effects in experimental animals. The present study investigated the influence of L-histidine on the protective effects of carbamazepine and phenytoin against maximal electroshock-induced seizures in mice.

L-Histidine, administered at the doses that did not influence the threshold for electroconvulsions (250–500 mg/kg), enhanced by nearly 30% the protective effects of carbamazepine against maximal electroshock-induced seizures. D-Histidine (1000 mg/kg), an inactive isomer of histidine, was without any effect in this regard. L-Histidine (500 mg/kg) also augmented the protective effects of phenytoin. Importantly, the enhancement of the anticonvulsant effects of these antiepileptic drugs produced by L-histidine co-administration was not associated with augmentation of their unwanted effects on memory and motor performance. A pharmacokinetic interaction was also excluded since the free plasma levels of these antiepileptics remained unchanged in the presence of L-histidine. It may be suggested that L-histidine could serve as a beneficial adjuvant for selected antiepileptic drugs.

Keywords: L-Histidine – Histamine – Antiepileptic drugs – Mice – Epilepsy 

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Copyright information

© Springer-Verlag/Wien 2003

Authors and Affiliations

  • R. M. Kamiński
    • 1
  • D. Żółkowska
    • 2
  • M. Kozicka
    • 3
  • Z. Kleinrok
    • 3
  • S. J. Czuczwar
    • 1
    • 4
  1. 1.Isotope Laboratory, Institute of Agricultural Medicine, Lublin, PolandPoland
  2. 2.Department of Hygiene, Medical University, Lublin, PolandPoland
  3. 3.Department of Pharmacology and Toxicology, Medical University, Lublin, PolandPoland
  4. 4.Department of Pathophysiology, Medical University, Lublin, PolandPoland

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