Summary.
The effect of human recombinant growth hormone (hrGH) on intestinal adaptation in rats subjected to massive small bowel resection has been followed by monitoring changes in the tissue polyamine system and in red blood cell (RBC) polyamine levels. In parallel, the activities of monoamine oxidase A and B and diamine oxidase, the enzymes that catalyse one of the major routes of biogenic amine metabolism, oxidative deamination, were also examined.
The results suggest that whilst hrGH treatment accelerates adaptive intestinal hyperplasia evoked by the resection, it has no significant effect on RBC polyamine level or gut mucosal DNA concentration as measured 3 weeks post surgery. hrGH treated operated rats exhibited significantly lower amine oxidase activities which implies that GH may alter biogenic amine systems.
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Received February 13, 2002 Accepted June 27, 2002 Published online November 14, 2002
Acknowledgement We thank Ms Krystyna Adach, Zofia Grzelinska, Ing. M.Sc, and Ms Halina Kuchciak for skillful technical assistance.
Authors' address: Prof. W. Agnieszka Fogel, Institute of Biogenic Amines, Polish Academy of Sciences, 90364 Lodz, Poland, Fax: +48 42 6815283, E-mail: wafogel@mazurek.man.lodz.pl
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Fogel, W., Sasiak, K., Socha, J. et al. Effects of human growth hormone (hrGH) treatment on amine metabolism in rats subjected to extensive small bowel resection. Amino Acids 24, 57–62 (2003). https://doi.org/10.1007/s00726-002-0335-3
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DOI: https://doi.org/10.1007/s00726-002-0335-3