720 MHz Pulse EPR Imager with Arbitrary Waveform Generator-Based Bridge and Direct Sampling

Abstract

A pulse 720 MHz EPR imager with a permanent magnet, arbitrary waveform generator based excitation, and detection system operating in the direct sampling and signal down-conversion modes is presented. This flexible instrument allowed testing various acquisition modes and demonstrating its signal to noise ratio advantage over the previously used 250 MHz instrument.

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References

  1. 1.

    N. Devasahayam, R. Murugesan, K. Matsumoto, J.B. Mitchell, J.A. Cook, S. Subramanian, M.C. Krishna, J. Magn. Reson. 168, 110–117 (2004)

    ADS  Article  Google Scholar 

  2. 2.

    M. Tseitlin, R.W. Quine, G.A. Rinard, S.S. Eaton, G.R. Eaton, J. Magn. Reson. 213, 119–125 (2011)

    ADS  Google Scholar 

  3. 3.

    P.E. Spindler, Y. Zhang, B. Endeward, N. Gershernzon, T.E. Skinner, S.J. Glaser, T.F. Prisner, J. Magn. Reson. 218, 49–58 (2012)

    ADS  Article  Google Scholar 

  4. 4.

    A. Doll, S. Pribitzer, R. Tschaggelar, G. Jeschke, J. Magn. Reson. 230, 27–39 (2013)

    ADS  Article  Google Scholar 

  5. 5.

    H. Sato-Akaba, M. Tseytlin, J. Magn. Reson. 304, 42–52 (2019)

    ADS  Article  Google Scholar 

  6. 6.

    R.H. Pursley, G. Salem, T.J. Pohida, N. Devasahayam, S. Subramanian, M.C. Krishna, Rev. Sci. Instrum. 76(3), 1–6 (2005). https://doi.org/10.1063/1.1903163

    Article  Google Scholar 

  7. 7.

    S. Subramanian, R. Murugesan, N. Devasahayam, J.A. Cook, M. Afeworki, T. Pohida, R.G. Tschudin, J.B. Mitchell, M.C. Krishna, J. Magn. Reson. 137, 379–388 (1999)

    ADS  Article  Google Scholar 

  8. 8.

    G. Schwarz, Munchner Medizinische Wochenschrift 56, 1217–1218 (1909)

    Google Scholar 

  9. 9.

    R.H. Thomlinson, L.H. Gray, Br. J. Radiol. 9, 539–563 (1955)

    Google Scholar 

  10. 10.

    R. Turner, Magn. Reson. Imaging 11, 903–920 (1993)

    Article  Google Scholar 

  11. 11.

    S.V. Sundramoorthy, B. Epel, H.J. Halpern, Appl. Magn. Reson. 48, 805–811 (2017)

    Article  Google Scholar 

  12. 12.

    B. Epel, M.K. Bowman, C. Mailer, H.J. Halpern, Magnet Reson Med 72, 362–368 (2014)

    Article  Google Scholar 

  13. 13.

    B. Epel, S.V. Sundramoorthy, C. Mailer, H.J. Halpern, Conc. Magn. Reson. B 33B, 163–176 (2008)

    Article  Google Scholar 

  14. 14.

    K.J. Liu, P. Gast, M. Moussavi, S.W. Norby, N. Vahidi, T. Walczak, M. Wu, H.M. Swartz, Proc. Natl Acad. Sci. USA 90, 5438–5442 (1993)

    ADS  Article  Google Scholar 

  15. 15.

    G.A. Rinard, R.W. Quine, J.R. Harbridge, R.T. Song, G.R. Eaton, S.S. Eaton, J. Magn. Reson. 140, 218–227 (1999)

    ADS  Article  Google Scholar 

  16. 16.

    B. Epel, H.J. Halpern, Emagres 6, 149–160 (2017)

    ADS  Article  Google Scholar 

  17. 17.

    H.J. Halpern, M.K. Bowman, EPR Imaging at MHz frequencies, in EPR Imaging and in vivo EPR. ed. by G.R. Eaton, S.S. Eaton, eK. Ohno (CRC Press, Boca Raton, FL, 1991)

    Google Scholar 

  18. 18.

    G.A. Rinard, S.S. Eaton, G.R. Eaton, J.C.P. Poole, H.A. Farach, in Handbook of electron spin resonance. ed. by C. Poole, H. Farach (New York, Springer Verlag, 1999)

    Google Scholar 

  19. 19.

    G.A. Rinard, R.W. Quine, S.S. Eaton, G.R. Eaton, J Magn Reson 156, 113–121 (2002)

    ADS  Article  Google Scholar 

  20. 20.

    R.T. Weber, J.A.J.M. Disselhorst, L.J. Prevo, J. Schmidt, W.T. Wenckebach, J. Magn. Reson. 81, 129–144 (1989)

    ADS  Google Scholar 

  21. 21.

    R. Nakaoka, D. Komarov, S. Matsumoto, H. Hirata, Appl. Magn. Reson. 49, 853–867 (2018)

    Article  Google Scholar 

  22. 22.

    G.A. Rinard, R.W. Quine, L.A. Buchanan, S.S. Eaton, G.R. Eaton, B. Epel, S.V. Sundramoorthy, H.J. Halpern, Appl. Magn. Reson. 48, 1227–1247 (2017)

    Article  Google Scholar 

  23. 23.

    M. Tseytlin, B. Epel, S. Sundramoorthy, D. Tipikin, H.J. Halpern, J. Magn. Reson. 272, 91–99 (2016)

    ADS  Article  Google Scholar 

  24. 24.

    B. Epel, M.K. Bowman, C. Mailer, H.J. Halpern, Magn Reson Med 72, 362–368 (2014)

    Article  Google Scholar 

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Acknowledgements

We acknowledge our colleagues from the Center for EPR Imaging In vivo Physiology at the University of Chicago and National Institutes of Health (NIH USA) grants P41EB002034, R01CA098575, and R50 CA211408. BE and HJH are are also members of a start-up company O2M Technologies.

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Correspondence to Boris Epel.

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Epel, B., Sundramoorthy, S.V. & Halpern, H.J. 720 MHz Pulse EPR Imager with Arbitrary Waveform Generator-Based Bridge and Direct Sampling. Appl Magn Reson (2021). https://doi.org/10.1007/s00723-021-01315-4

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