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Design and Fabrication of Compact Arrayed Magnet for Biological EPR Imaging

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Abstract

A portable and compact electron paramagnetic resonance (EPR) imaging magnet was developed for building a 750 MHz EPR imaging system. To realize low-cost fabrication, it was shown that the magnetic homogeneity required for redox EPR imaging using nitroxyl probes can be approximately reproduced by regularly arranging small neodymium magnets that are easy to handle. A five-channel coil driver consisting of operational amplifiers and switching power supplies was developed for field sweep, field modulation, and three field gradients to downsize the imaging system. The EPR imaging of 4-oxo-2,2,6,6-tetramethylpiperidine-d16-1-oxyl (tempone-d16) using a phantom was successfully performed by employing a 3D radial sequence controlled by a digital EPR console.

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Acknowledgements

This work was supported by Grants awarded by the Japan Society for the Promotion of Science (JP18K04164 to H. S.), the Murata Science Foundation (to H. S.), and in part by JKA and its promotion funds from KEIRIN RACE* (to M. E.).

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Authors and Affiliations

  1. Department of Systems Innovation, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, 560-8531, Japan

    Hideo Sato-Akaba

  2. School of Engineering Science, Osaka University, Toyonaka, Osaka, 560-8531, Japan

    Yuki Okada & Kentaro Tsuji

  3. Health Sciences University of Hokkaido, Sapporo, Hokkaido, 002-8072, Japan

    Miho C. Emoto

  4. Health Sciences University of Hokkaido, Ishikari, Hokkaido, 061-0293, Japan

    Hirotada G. Fujii

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  1. Hideo Sato-Akaba
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  2. Yuki Okada
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  5. Hirotada G. Fujii
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Correspondence to Hideo Sato-Akaba.

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Sato-Akaba, H., Okada, Y., Tsuji, K. et al. Design and Fabrication of Compact Arrayed Magnet for Biological EPR Imaging. Appl Magn Reson 52, 1017–1029 (2021). https://doi.org/10.1007/s00723-020-01256-4

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  • DOI: https://doi.org/10.1007/s00723-020-01256-4

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