Abstract
We investigated the influence of gadolinium (Gd)-based upconverting nanoparticles (UCNPs) on water spin–lattice relaxation (T1) and diffusion at different magnetic field strengths (0.4 T and 9.4 T). Our findings show that smaller NPs (12 nm compared to 19 nm) were more favourable for proton relaxivity. We also demonstrate that using simplified Solomon–Bloembergen–Morgan (SBM) model we can associate two measured diffusion coefficients with processes occurring near the surface of UCNPs and in bulk water. Using the relationship between relaxation and diffusion, we can estimate not only the total impact of NPs on relaxation of water molecules, but also the impact on relaxation of local water molecules, directly connected to paramagnetic Gd3+ ions in NPs. Different magnetic field strengths did not alter the spin–lattice relaxivity of NPs. This suggests that Gd-based UCNPs could be developed into high-performance multimodal magnetic resonance imaging contrast agents working over a broad range of imaging field strengths used in clinical routine.
Similar content being viewed by others
References
S.C. Partridge, N. Nissan, H. Rahbar, A.E. Kitsch, E.E. Sigmund, JMRI 45, 337–355 (2017)
A.M. Priola, S.M. Priola, D. Gned, E. Piacibello, D. Sardo, G. Parvis, D. Torti, F. Ardissone, A. Veltri, JMRI 44, 758–769 (2016)
S. Verma, A. Rajesh, J.J. Fütterer, B. Turkbey, T.W.J. Scheenen, Y. Pang, P.L. Choyke, J. Kurhanewicz, AJR 194, 1414–1426 (2010)
C.M. Rios, M.P. McAndrews, W. Logan, T. Krings, D. Lee, E. Widjaja. JMRI 44, 12–22 (2016)
T.F. Budinger, M.D. Bird, L. Frydman, J.R. Long, T.H. Mareci, W.D. Rooney, B. Rosen, J.F. Schenck, V.D. Schepkin, A.D. Sherry, D.K. Sodickson, C.S. Springer, K.R. Thulborn, K. Ugurbil, L.L. Wald, Magn. Reson. Mater. Phy. 29, 617–639 (2016)
P. Caravan, ChT Farrar, L. Frullano, R. Uppal, Contrast. Media Mol. Imaging 4(2), 89–100 (2009)
V. Jacques, S. Dumas, WCh. Sun, J.S. Troughton, M.T. Greenfield, P. Caravan, Invest. Radiol. 45(10), 613–624 (2010)
M. Rohrer, H. Bauer, J. Mintorovich, M. Requardt, H.J. Weinmann, Invest. Radiol. 40, 715–724 (2005)
A.M. Panich, N.A. Sergeev, Appl. Magn. Reson. 49, 195–208 (2018)
F.C.J.M. van Veggel, C. Dong, N.J.J. Johnson, J. Pichaandi. Nanoscale 4, 7309–7321 (2012)
L. Dongdong, S. Qiyue, D. Yan, J. Jianqing, J. Rare Earths 32(11), 1032–1036 (2014)
C. Liu, Z. Gao, J. Zeng, Y. Hou, F. Fang, Y. Li, R. Qiao, L. Shen, H. Lei, W. Yang, M. Gao, ACS Nano 7(8), 7227–7240 (2013)
G.A. Pereira, C.F.G.C. Geraldes, Ann. Magn. Reson. 6(1/2), 1–33 (2007)
R.D.A. Alvares, A. Gautam, R.S. Prosser, F.C.J.M. van Veggel, P.M. Macdonald, J. Phys. Chem. 121, 17552–17558 (2017)
V.C. Pierre,́ S.M. Harris, S.L. Pailloux. Acc. Chem. Res. 51, 342-351 (2018)
D. Ni, W. Bu, E.B. Ehlerding, W. Cai, J. Shi. Chem. Soc. Rev. 46, 7438–7468 (2017)
D. Baziulyte-Paulaviciene, V. Karabanovas, M. Stasys, G. Jarockyte, V. Poderys, S. Sakirzanovas, R. Rotomskis, Beilstein J. Nanotechnol. 8, 1815–1824 (2017)
M. Ding, D. Chen, S. Yin, Z. Ji, J. Zhong, Y. Ni, C. Lu, Z. Xu, Sci. Rep. 5(12745), 1–14 (2015)
E. Von Goldammer, H.G. Hertz, J. Phys. Chem. 74, 3734–3755 (1970)
V.I. Chizhik, Y.S. Chernyshev, A.V. Donets, V.V. Frolov, A.V. Komolkin, M.G. Shelyapina, Magnetic Resonance and Its Applications (Springer, Berlin, 2014) p. 206
X.Y. Zheng, K. Zhao, J. Tang, X.Y. Wang, L.D. Li, N.X. Chen, Y.J. Wang, S. Shi, X. Zhang, S. Malaisamy, L.D. Sun, X. Wang, C. Chen, C.H. Yan, ACS Nano 11, 3642–3650 (2017)
F. Chen, W. Bu, S. Zhang, X. Liu, J. Liu, H. Xing, Q. Xiao, L. Zhou, W. Peng, L. Wang, J. Shi, Adv. Funct. Mater. 21, 4285–4294 (2011)
N.J. Johnson, S. He, V.A. Nguyen Huu, A. Almutairi, ACS Nano 10, 8299–8307 (2016)
N.J.J. Johnson, W. Oakden, G.J. Stanisz, R.S. Prosser, F.C.J.M. van Veggel, Chem. Mater. 23, 3714–3722 (2011)
Y. Hou, R. Qiao, F. Fang, X. Wang, C. Dong, K. Liu, C. Liu, Z. Liu, H. Lei, F. Wang, M. Gao, ACS Nano 7(1), 330–338 (2013)
Acknowledgements
One of us (K.K.) thanks for the hospitality of Prof. Dr. Stefan Jurga group in NanoBioMedical Center, Poznan, where the part of the experiments were carried out. Special thanks to Dr. Grzegorz Nowaczyk for the TEM measurements and Prof. Dr. Vytautas Balevicius and Laurynas Dagys for their help during the experiments and discussions.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kristinaityte, K., Zalewski, T., Kempka, M. et al. Spin–Lattice Relaxation and Diffusion Processes in Aqueous Solutions of Gadolinium-Based Upconverting Nanoparticles at Different Magnetic Fields. Appl Magn Reson 50, 553–561 (2019). https://doi.org/10.1007/s00723-018-1105-z
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00723-018-1105-z