Combined palladium/eosin Y-catalysed direct synthesis of anticancer biarylquinolinooxazocino-quinoxaline-1-ones under visible light in one-pot sequence: a revisited proof of concept

Abstract

A novel, efficient, and green catalytic system under visible light irradiation has been introduced for the synthesis of anticancer biarylquinolooxazocino-quinoxaline-1-ones in one-pot sequence. The developed synthetic approach will be successfully utilized for the synthesis of various bioactive biarylquinolone in near future. Also, the cytotoxicity profile of these scaffolds has unveiled their superb cytoselectivity in HeLa and MCF-7 cell line compared to cisplatin.

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Acknowledgements

The authors gratefully acknowledge VIT for providing ‘VIT SEED GRANT’, Vellore for the support through Seed Grant for Research. We acknowledge DST, New Delhi, India for DST-FIST project.

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Correspondence to Priyankar Paira.

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Roy, N., Paira, P. Combined palladium/eosin Y-catalysed direct synthesis of anticancer biarylquinolinooxazocino-quinoxaline-1-ones under visible light in one-pot sequence: a revisited proof of concept. Monatsh Chem (2020). https://doi.org/10.1007/s00706-020-02641-2

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Keywords

  • Anticancer drug
  • Biarylquinolinooxazocino-quinoxaline-1-ones
  • Green technology
  • Eosin Y
  • Cellular imaging