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Synthesis approach and biological activity evaluation of a series of 1,3,2-oxazaphosphole-2-oxides against inflammation and nociception

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Abstract

In the present work, we synthesized a series of substituted benzoxazaphosphole-2-oxides in high yields (68–84%). The approach involved the preparation of oxazaphospholo-2-oxide monochloride, which is the key substrate, followed by its treatment with amino-, hydroxyl-, and thiolocompounds under mild conditions to afford the corresponding cyclophosphamide, cyclophosphamidate, and cyclophosphathioamidate groups as target products. Lipophilicity prediction and in vivo antinociceptive and antiinflammatory properties of new molecules were determined. Out of 14 tested compounds, the most hydrophobic compounds were found to be also of the highest antinociceptive and the antiinflammatory effects compared with reference drugs ibuprofen and indomethacin. The pharmacological results also showed that three candidates from the cyclophosphamide group are more active as antiinflammatory agents than the reference drug at all the successive time intervals.

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Acknowledgements

Authors like to thank the National Research Centre, Dokki, Cairo Egypt (project # 10010340) for financial support. Authors also like to thank the Central Lab, School of Pharmacy, Alexandria University, Egypt for taking care of biological assays.

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Authors and Affiliations

  1. Chemical Industries Research Division, National Research Centre, Elbuhouth St., Dokki, Cairo, 12622, Egypt

    Wafaa M. Abdou, Eman Sabry & Abeer A. Shaddy

Authors
  1. Wafaa M. Abdou
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  2. Eman Sabry
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  3. Abeer A. Shaddy
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Correspondence to Wafaa M. Abdou or Eman Sabry.

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Abdou, W.M., Sabry, E. & Shaddy, A.A. Synthesis approach and biological activity evaluation of a series of 1,3,2-oxazaphosphole-2-oxides against inflammation and nociception. Monatsh Chem 150, 283–294 (2019). https://doi.org/10.1007/s00706-018-2312-x

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  • DOI: https://doi.org/10.1007/s00706-018-2312-x

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