Three-component, solvent-free synthesis of Betti base catalyzed by sulfated polyborate

  • Manisha S. Patil
  • Chetan K. Khatri
  • Ganesh U. Chaturbhuj
Original Paper

Abstract

In this work, efficient, mild, and eco-friendly procedure of 1-aminoalkyl-2-phenol/Betti base from one-pot three-component condensations of aldehyde, phenol, and morpholine in the presence of sulfated polyborate catalyst, under a solvent-free condition at 100 °C, is described. The key advantages of the present method are short reaction time, high yields, aqueous work-up procedure, low cost, stable, reusable catalyst, and solvent-free reaction conditions.

Graphical abstract

Keywords

Sulfated polyborate Betti base Solvent free Recyclable catalyst 

Notes

Acknowledgements

The authors are grateful to the Department of Science and Technology, New Delhi, India for their financial supports.

Supplementary material

706_2018_2169_MOESM1_ESM.docx (168 kb)
Supplementary material 1 (DOCX 167 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Manisha S. Patil
    • 1
  • Chetan K. Khatri
    • 1
  • Ganesh U. Chaturbhuj
    • 1
  1. 1.Department of Pharmaceutical Sciences and TechnologyInstitute of Chemical TechnologyMumbaiIndia

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