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Synthesis of 2-chloro-3-oxoesters by reaction of the dianion of ethyl 2-chloroacetoacetate with electrophiles

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Abstract

2-Chloro-3-oxoalkanoates and related molecules were prepared by regioselective reaction of the dianion of ethyl 2-chloroacetoacetate with alkyl halides and other electrophiles.

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Acknowledgments

Financial support from the State of Mecklenburg-Vorpommern is gratefully acknowledged.

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Authors and Affiliations

  1. Institut für Chemie, Universität Rostock, Albert Einstein Str. 3a, 18059, Rostock, Germany

    Verena Specowius, Thomas Rahn, Muhammad Adeel, Stefanie Reim, Holger Feist & Peter Langer

  2. Leibniz-Institut für Katalyse an der Universität Rostock e.V., Albert Einstein Str. 29a, 18059, Rostock, Germany

    Peter Langer

  3. Department of Chemistry, Gomal University Dera Ismael Khan, Khyber-Pakhtunkhwa, Dera Ismael Khan, Pakistan

    Thomas Rahn & Muhammad Adeel

  4. Scientific and Production Center “Armbiotechnology” of NAS RA, Gyurjyan str. 14, 0056, Yerevan, Armenia

    Ashot S. Saghyan

  5. Department of Chemistry, Yerevan State University, Alex Manoogian 1, 0025, Yerevan, Armenia

    Ashot S. Saghyan

Authors
  1. Verena Specowius
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  2. Thomas Rahn
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  3. Muhammad Adeel
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  4. Stefanie Reim
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  5. Holger Feist
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  6. Ashot S. Saghyan
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  7. Peter Langer
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Corresponding author

Correspondence to Peter Langer.

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Specowius, V., Rahn, T., Adeel, M. et al. Synthesis of 2-chloro-3-oxoesters by reaction of the dianion of ethyl 2-chloroacetoacetate with electrophiles. Monatsh Chem 144, 627–631 (2013). https://doi.org/10.1007/s00706-012-0897-z

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  • DOI: https://doi.org/10.1007/s00706-012-0897-z

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