Archives of Virology

, Volume 163, Issue 5, pp 1285–1291 | Cite as

Genetic diversity of Orf virus isolated from sheep in Uruguay

  • Natalia Olivero
  • Eduardo Reolon
  • Juan Arbiza
  • Mabel Berois
Brief Report


Orf virus (ORFV) is the etiological agent of contagious ecthyma, a disease widely spread in the world that occasionally causes zoonotic infections. This work is the first molecular characterization of ORFV in Uruguay, where we analyzed twenty-one sheep samples, eighteen of which were recovered from thirteen ORFV outbreaks that occurred during 2004 to 2011 as well as three strains from a national vaccine. Phylogenetic analysis and the derived amino acid sequences from the B2L gene suggest that the Uruguayan virus do not form a unique cluster, with most of them displaying similarities with worldwide ORFV isolates as well as our vaccine strains.


Orf virus B2L gene Sheep Contagious ecthyma 



This work was partially funded by Agencia Nacional de Investigación e Innovación ANII (FCE2009_2504), Programa de Desarrollo de las Ciencias Básicas (PEDECIBA) and Universidad de la República, Uruguay. N.O. was recipient of a postgraduate fellowship from ANII. We are grateful to S. Mirazo from Sección Virología, Facultad de Ciencias for the critical reading of the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with animals performed by any of the authors.


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Sección Virología, Facultad de CienciasUdelaRMontevideoUruguay
  2. 2.Laboratorios Virbac-Santa ElenaMontevideoUruguay
  3. 3.Institut Pasteur de MontevideoMontevideoUruguay
  4. 4.Biogénesis Bagó S.AGarinArgentina

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