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Genetic diversity of Orf virus isolated from sheep in Uruguay

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Abstract

Orf virus (ORFV) is the etiological agent of contagious ecthyma, a disease widely spread in the world that occasionally causes zoonotic infections. This work is the first molecular characterization of ORFV in Uruguay, where we analyzed twenty-one sheep samples, eighteen of which were recovered from thirteen ORFV outbreaks that occurred during 2004 to 2011 as well as three strains from a national vaccine. Phylogenetic analysis and the derived amino acid sequences from the B2L gene suggest that the Uruguayan virus do not form a unique cluster, with most of them displaying similarities with worldwide ORFV isolates as well as our vaccine strains.

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Acknowledgements

This work was partially funded by Agencia Nacional de Investigación e Innovación ANII (FCE2009_2504), Programa de Desarrollo de las Ciencias Básicas (PEDECIBA) and Universidad de la República, Uruguay. N.O. was recipient of a postgraduate fellowship from ANII. We are grateful to S. Mirazo from Sección Virología, Facultad de Ciencias for the critical reading of the manuscript.

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Author notes

  1. Natalia Olivero

    Present address: Institut Pasteur de Montevideo, 11400, Montevideo, Uruguay

  2. Eduardo Reolon

    Present address: Biogénesis Bagó S.A, 1619, Garin, Argentina

Authors and Affiliations

  1. Sección Virología, Facultad de Ciencias, UdelaR, Iguá 4225, 11400, Montevideo, Uruguay

    Natalia Olivero, Juan Arbiza & Mabel Berois

  2. Laboratorios Virbac-Santa Elena, 12900, Montevideo, Uruguay

    Eduardo Reolon

Authors
  1. Natalia Olivero
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  2. Eduardo Reolon
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  3. Juan Arbiza
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  4. Mabel Berois
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Corresponding author

Correspondence to Mabel Berois.

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The authors declare that they have no conflict of interest.

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This article does not contain any studies with animals performed by any of the authors.

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Handling Editor: Diego G. Diel.

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Olivero, N., Reolon, E., Arbiza, J. et al. Genetic diversity of Orf virus isolated from sheep in Uruguay. Arch Virol 163, 1285–1291 (2018). https://doi.org/10.1007/s00705-018-3717-x

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  • DOI: https://doi.org/10.1007/s00705-018-3717-x

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