Investigation of the effects of a prevention of mother-to-child HIV transmission program among Iranian neonates
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Human immunodeficiency virus (HIV) infection is mostly spreading in developing countries. One of the most important pathways of HIV infection in these nations is the vertical route, from mother to infant. Therefore, this study evaluated the effectiveness of the prevention of mother-to-child transmission (PMTCT) program for HIV among Iranian neonates born to HIV-positive mothers. A total of 54 neonates born to HIV-1 positive mothers, all of whom were in a PMTCT program for HIV, as per the Iranian guidelines, were enrolled in this descriptive cross sectional study from March 2014 to July 2017. After RNA extraction of a plasma specimen, HIV-1 viral load was tested by an Artus HIV-1 RG RT-PCR Kit. Out of 54 evaluated neonates, 32 (59.3%) were male. The mean age of the HIV-infected mothers was 30.1 ± 5.4 (range: 19–47) years, and 36 (66.7%) of the mothers were in the age group 26–34 years. In the present study, it was found that none of the neonates whose mothers had previously entered PMTCT programs had HIV. 15 children were found who were born to HIV-positive mothers who had not entered the PMTCT program. Three of these children were infected with HIV (CRF35_AD), and none of them carried HIV-1 variants with SDRMs. The results of this study indicate that if HIV-positive pregnant women enter the PMTCT program for HIV, they can realistically hope to give birth to a non-infected child.
The authors would like to thank all of the candidates who generously enrolled in this research.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflicts of interest.
Ethical approval for this study was obtained from the local ethics committee of the IUMS, Tehran, Iran, that is accordance with Helsinki declaration. All of the parents of the infants were informed about the current study, with a written consent form received prior to their enrollment. All the experiments were carried out in the HIV Laboratory of National Centre, Deputy of Health, IUMS, Tehran, Iran.
Sources of funding
The current study was funded by Research Deputy of Iran University of Medical Sciences, Tehran, Iran with Grant Number 26050.
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