Abstract
In 2011, human coxsackievirus B5 (CVB5) caused an outbreak of viral encephalitis in Henan, China. Complete genome sequence analysis based on two isolates showed that the 5′ half of the genome (nt 1-4540) had high similarity (>97 %) to that of CVB5 strain GU376747, and the 3′ half (nt 4700–7402) showed high similarity (>96 %) to that of human coxsackievirus B3 (CVB3) strain GQ141875. These isolates had the highest similarity (97.7 %) to the Changchun strain, based on the complete genome, rather than to other CVB5 strains isolated from Henan in recent years. There were therefore at least two groups of CVB5 circulating in Henan Province, which evolved at different rates.
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Acknowledgments
We sincerely acknowledge the cooperation of Luohe Center for Disease Control and Prevention in this study. This work was sponsored by Henan Province Health Department and China’s Ministry of Health Co-build Project (201201003) and Henan Department of Science and Technology Project (122400450357). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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None declared.
Ethical Standard
This research was approved by the Review Board of Henan Center for Disease Control and Prevention. Informed consent was received from the participants prior to the study.
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Ma, H., Huang, X., Kang, K. et al. Recombination in human coxsackievirus B5 strains that caused an outbreak of viral encephalitis in Henan, China. Arch Virol 158, 2169–2173 (2013). https://doi.org/10.1007/s00705-013-1709-4
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DOI: https://doi.org/10.1007/s00705-013-1709-4