90 years of monoamine oxidase: some progress and some confusion

  • Keith F. Tipton
Neurology and Preclinical Neurological Studies - Review Article


It would not be practical to attempt to deal with all the advances that have informed our understanding of the behavior and functions of this enzyme over the past 90 years. This account concentrates key advances that explain why the monoamine oxidases remain of pharmacological and biochemical interest and on some areas of continuing uncertainty. Some issues that remain to be understood or are in need of further clarification are highlighted.


Monoamine oxidase reaction Inhibitors Kinetics, suicide substrates Parkinson’s disease Ammonia Aldehydes Hydrogen peroxide Imidazolines Depression Propargylamines Hydrazines Cyclopropylamines 



Parkinson’s disease




Monoamine oxidase


Monoamine oxidase inhibitor






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© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.School of Biochemistry and ImmunologyTrinity CollegeDublin 2Ireland

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