Abstract
In a prospective 5-year study among Parkinson’s disease (PD) tremor-dominant (TD) patients, we investigated who will remain TD and who will later convert into the postural instability gait difficulty (PIGD) phenotype. At follow-up, 38% were still considered TD. At baseline the TD non-convertors had more years of education and better cognitive function than the convertors and significantly smaller deterioration in gait, balance, cognitive function and other non-motor symptoms. These results highlight the potential role of cognition in protecting against the development of PIGD symptoms.
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Acknowledgements
This work was supported in part by a Grant from the Michael J. Fox Foundation for Parkinson’s Research.
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TH, LA, SS declare no financial or other conflicts of interest. Prof. Hausdorff reports Grants from Michael J Fox Foundation, during the conduct of the study. Prof. Giladi serves as a member of the Editorial Board for the Journal of Parkinson’s Disease. He serves as consultant to Teva- NeuroDerm, Biogen, Pharma2B, Denali, Abbvie, AccelMed, Monfort and UCB. He receives royalties from LTI and payment for lectures at Teva, UCB, Abviee, Bial and Movement Disorder Society. He received research support from the Michael J Fox Foundation, the National Parkinson Foundation, the European Union 7th Framework Program and the Israel Science Foundation as well as from Teva NNE program, Biogen, LTI, and Pfizer.
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Herman, T., Shema-Shiratzky, S., Arie, L. et al. Who will remain tremor dominant? The possible role of cognitive reserve in the time course of two common Parkinson’s disease motor subtypes. J Neural Transm 125, 1007–1011 (2018). https://doi.org/10.1007/s00702-018-1859-3
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DOI: https://doi.org/10.1007/s00702-018-1859-3