Journal of Neural Transmission

, Volume 125, Issue 6, pp 1007–1011 | Cite as

Who will remain tremor dominant? The possible role of cognitive reserve in the time course of two common Parkinson’s disease motor subtypes

  • Talia Herman
  • S. Shema-Shiratzky
  • L. Arie
  • N. Giladi
  • J. M. Hausdorff
Neurology and Preclinical Neurological Studies - Short communication


In a prospective 5-year study among Parkinson’s disease (PD) tremor-dominant (TD) patients, we investigated who will remain TD and who will later convert into the postural instability gait difficulty (PIGD) phenotype. At follow-up, 38% were still considered TD. At baseline the TD non-convertors had more years of education and better cognitive function than the convertors and significantly smaller deterioration in gait, balance, cognitive function and other non-motor symptoms. These results highlight the potential role of cognition in protecting against the development of PIGD symptoms.


Parkinson’s disease Tremor dominant PIGD Gait Cognitive function 



This work was supported in part by a Grant from the Michael J. Fox Foundation for Parkinson’s Research.

Compliance with ethical standards

Conflict of interest

TH, LA, SS declare no financial or other conflicts of interest. Prof. Hausdorff reports Grants from Michael J Fox Foundation, during the conduct of the study. Prof. Giladi serves as a member of the Editorial Board for the Journal of Parkinson’s Disease. He serves as consultant to Teva- NeuroDerm, Biogen, Pharma2B, Denali, Abbvie, AccelMed, Monfort and UCB. He receives royalties from LTI and payment for lectures at Teva, UCB, Abviee, Bial and Movement Disorder Society. He received research support from the Michael J Fox Foundation, the National Parkinson Foundation, the European Union 7th Framework Program and the Israel Science Foundation as well as from Teva NNE program, Biogen, LTI, and Pfizer.

Supplementary material

702_2018_1859_MOESM1_ESM.docx (39 kb)
Supplementary material 1 (DOCX 38 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.The Center for the Study of Movement, Cognition and Mobility, Neurological InstituteTel Aviv Sourasky Medical CenterTel AvivIsrael
  2. 2.Department of Physical Therapy, Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  3. 3.Sagol School of NeuroscienceTel Aviv UniversityTel AvivIsrael
  4. 4.Department of Neurology, Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  5. 5.Rush Alzheimer’s Disease Center and Department of Orthopaedic SurgeryRush University Medical CenterChicagoUSA

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