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Journal of Neural Transmission

, Volume 125, Issue 4, pp 699–703 | Cite as

Pupillometry as an indicator of l-DOPA dosages in Parkinson’s disease patients

  • O. Bartošová
  • C. Bonnet
  • O. Ulmanová
  • M. Šíma
  • F. Perlík
  • E. Růžička
  • O. Slanař
Neurology and Preclinical Neurological Studies - Original Article

Abstract

Dopamine was shown to induce mydriasis by excitation of alpha-adrenergic receptors at the dilator pupillae muscle. Pupilla diameter may thus serve as an indirect measure of peripheral pharmacokinetics of l-DOPA and dopamine. The aim of this study is to evaluate the effect of l-DOPA dosage on pupillometric parameters in Parkinson’s disease (PD) patients. Sixteen PD patients and 14 healthy control subjects (CS) were studied. The statistical analysis revealed significant differences between CS and PD patients for the mean maximum and minimum pupil diameters (p = 0.017, p = 0.028, respectively), with higher values found in PD. Moreover, a significant dose–response relationship was found between the maximum pupil diameter and both the morning l-DOPA dose (R 2 = 0.78) and the total daily l-DOPA dose (R 2 = 0.93). A sigmoid-shaped curve best describes the dose–response relationship, with a ceiling effect at about 400 mg l-DOPA daily dose. In conclusion, measuring pupillometric parameters represents a sensitive tool for non-invasive evaluation of the peripheral effect of l-DOPA, especially with daily doses below 400 mg l-DOPA.

Keywords

Pupillometry l-DOPA Parkinson’s disease Dose–response relationship Pupil parameters Maximum pupil diameter 

Abbreviations

BDI

Beck depression inventory

CS

Control subjects

D1, D2

Dopamine receptors

DIF

Difference between MAX and MIN

FAB

Frontal assessment battery

MAX

Maximum pupil parameter

MIN

Minimum pupil parameter

MMSE

Mini-mental state examination

PD

Parkinson’s disease

R2

R-squared for nonlinear regression

T

Latency for the onset of constriction

UPDRS

Unified Parkinson’s disease rating scale

VAR

Variation ((MAX − MIN)/MAX) × 100

VCmax

Maximum constriction velocity

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Department of Pharmacology, First Faculty of MedicineCharles University and General University HospitalPragueCzech Republic
  2. 2.Department of Neurology and Centre of Clinical Neuroscience, First Faculty of MedicineCharles University and General University HospitalPragueCzech Republic

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