Acta Neurochirurgica

, Volume 161, Issue 6, pp 1087–1088 | Cite as

Response to the Letter to the Editor “Lipomatosis of nerve and overgrowth syndrome: an intriguing and still unclear correlation”

  • Tomas Marek
  • Mark A. Mahan
  • Kimberly K. Amrami
  • Robert J. SpinnerEmail author
Letter to the Editor (by Invitation) - Peripheral Nerves
Part of the following topical collections:
  1. Peripheral Nerves

To the editor,

We appreciate the letter to the editor by Vetrano et al. [11] regarding our recent paper on lipomatosis of nerve (LN) [5]. Our group has been interested in LN as well as other adipose lesions of nerves for many years [3, 4, 9].

First, we agree with the authors that there is a great inconsistency in the terminology in the world’s literature of LN. Besides the term lipomatosis of nerve, which has been proposed by WHO in 2002 [2], many other terms are regularly used including fibrolipomatous hamartoma, lipofibromatous hamartoma, neural lipoma, and macrodystrophia lipomatosa, for a spectrum of pathologies. This terminology problem was one of the major reasons that we decided to compile the world’s literature and perform the systematic review (which included the recent case by Vetrano et al. [10]). Our systematic review is now published in JNS [6]. This study strengthened the association of LN and nerve-territory overgrowth. We then utilized the raw data from this large...



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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Tomas Marek
    • 1
  • Mark A. Mahan
    • 2
  • Kimberly K. Amrami
    • 3
  • Robert J. Spinner
    • 1
    Email author
  1. 1.Department of Neurologic SurgeryMayo ClinicRochesterUSA
  2. 2.Department of Neurologic SurgeryUniversity of UtahSalt Lake CityUSA
  3. 3.Department of RadiologyMayo ClinicRochesterUSA

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