Acta Neurochirurgica

, Volume 161, Issue 6, pp 1085–1086 | Cite as

Lipomatosis of nerve and overgrowth syndrome: an intriguing and still unclear correlation

  • Ignazio G. VetranoEmail author
  • Luca Maria Sconfienza
  • Grazia Devigili
  • Vittoria Nazzi
Letter to the editor - Peripheral Nerves
Part of the following topical collections:
  1. Peripheral Nerves

Dear Editor,

We read with great interest the paper by Marek and co-authors entitled “Lipomatosis of nerve and overgrowth: is there a preference for motor (mixed) vs. sensory nerve involvement?” which recently appeared as “Online First Articles” in Acta Neurochirurgica [4].

Based on their extensive experience in this field [2, 3, 7], the authors present a summary literature review along with their Institutional cases of nerve lipomatosis (LN). This intriguing and in many ways still unclear condition consists of a fibroadipose epineurial proliferation, frequently associated with bone and soft-tissue enlargement. Due to the epineural and perineural fibrosis, nerve bundles can be strongly compressed, leading to an entrapment neuropathy [6]. Gigantism and overgrowth as asymmetric macrodactyly generally interest a part or a whole extremity, usually corresponding to the territory of distribution of a single nerve. Marek and coworkers analyzed the prevalence of overgrowth syndrome and nerves...


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of NeurosurgeryFondazione IRCCS Istituto Neurologico Carlo BestaMilanItaly
  2. 2.Department of Biomedical Sciences for HealthUniversity of MilanoMilanItaly
  3. 3.IRCCS Istituto Ortopedico GaleazziMilanItaly
  4. 4.Neurological Unit 1Fondazione IRCCS Istituto Neurologico Carlo BestaMilanItaly

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