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Acta Neurochirurgica

, Volume 161, Issue 5, pp 985–993 | Cite as

Diffusion-weighted magnetic resonance imaging for detection of postoperative intracranial pyogenic abscesses in neurosurgery

  • Christoph Schwartz
  • Markus Lenski
  • Alexander Romagna
  • Christian Schichor
  • Joerg-Christian Tonn
  • Hartmut Brueckmann
  • Hendrik Janssen
  • Thomas Liebig
  • Robert Forbrig
  • Niklas ThonEmail author
Original Article - Infection
  • 102 Downloads
Part of the following topical collections:
  1. Infection

Abstract

Background

Diffusion-weighted magnetic resonance imaging (MRI-DWI) is the modality of choice for detecting intracranial abscesses; however, it is unclear whether prior brain surgery has an influence on its diagnostic value. Thus, we assessed the robustness of MRI-DWI and determination of an ADC cutoff value for detecting intracranial abscesses in patients who underwent brain surgery.

Methods

We retrospectively evaluated 19 patients prior to surgery for postoperative supratentorial parenchymal abscesses by means of MRI-DWI. Forty randomly selected patients with routine postoperative MRI-DWI were used for comparative analyses. Clinical and serum biomarkers (C-reactive protein, interleukin-6, white blood cell count) as well as from results of early postoperative imaging findings (computed tomography and/or MRI scan) were recorded. Additionally, ADC values, T1±gadolinium, and T2/fluid-attenuated inversion recovery sequences were investigated.

Results

After initial surgery, early postoperative control imaging showed evidence of hemorrhage and/or hemostatic agents within the resection cavity in 10/19 patients of the abscess group and in 16/40 patients of the control group. No postoperative ischemia was detected. Neither hemostatic agents nor blood affected the mean ADC values in both the reference group (blood 2.96 ± 0.22 × 10−3 mm2/s vs. no blood 2.95 ± 0.26 × 10−3 mm2/s, p = 0.076) and in the abscess group (blood 0.87 ± 0.07 × 10−3 mm2/s vs. no blood 0.76 ± 0.06 × 10−3 mm2/s, p = 0.128). The mean ADC value within the resection cavity was significantly lower in the abscess group (1.5 T 0.88 ± 0.41 vs. 2.88 ± 0.20 × 10−3 mm2/s, p < .01; 3.0 T 0.75 ± 0.24 vs. 3.02 ± 0.26 × 10−3 mm2/s, p < 0.01). The optimal ADC cut-off for the differentiation of an abscess from normal postoperative findings was found at 1.87 × 10−3 mm2/s (area-under-the-curve 1.0, sensitivity = 100%, specificity = 100%). Moreover, no differences between the abscess patients and the control group were seen with respect to the analyzed serum biomarkers.

Conclusion

MRI-DWI provides a robust tool to discriminate postoperative abscess formation from normal postoperative changes.

Keywords

Apparent diffusion coefficient Diffusion-weighted MRI Neurosurgery Pyogenic intracranial abscess Revision surgery Serum biomarker 

Abbreviations

ADC

Apparent diffusion coefficient

CT

Computed tomography

CRP

C-reactive protein

CSF

Cerebrospinal fluid

DWI

Diffusion-weighted imaging

IL-6

Interleukin-6

MRI

Magnetic resonance imaging

WBCC

White blood cell count

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (ethics committee of the Ludwig-Maximilians-University Munich, Germany) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Christoph Schwartz
    • 1
    • 2
  • Markus Lenski
    • 1
  • Alexander Romagna
    • 1
    • 2
    • 3
  • Christian Schichor
    • 1
  • Joerg-Christian Tonn
    • 1
  • Hartmut Brueckmann
    • 4
  • Hendrik Janssen
    • 4
    • 5
  • Thomas Liebig
    • 4
  • Robert Forbrig
    • 4
  • Niklas Thon
    • 1
    Email author
  1. 1.Department of Neurosurgery, University HospitalLMU MunichMunichGermany
  2. 2.Department of NeurosurgeryChristian-Doppler-Klinik, Paracelsus Medical University SalzburgSalzburgAustria
  3. 3.Division of NeurosurgerySt. Michael’s Hospital, University of TorontoTorontoCanada
  4. 4.Institute of Neuroradiology, University HospitalLMU MunichMunichGermany
  5. 5.Department of NeuroradiologyKlinikum IngolstadtIngolstadtGermany

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