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Disseminated central nervous system hemangioblastoma in a patient with no clinical or genetic evidence of von Hippel-Lindau disease—a case report and literature review

  • Case Report - Brain Tumors
  • Published:
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Abstract

Background

Hemangioblastomas (HB) are benign tumors of the central nervous system (CNS) that can appear sporadic or as part of von Hippel-Lindau (VHL) disease. It is often curable with surgical resection, but upon relapse, the disease exhibits a treatment-refractory course.

Case report

A patient treated for sporadic cerebellar HB relapsed 12 years post-surgery. She developed disseminated disease throughout the CNS, including leptomeningeal manifestations. Repeat surgery and craniospinal radiation therapy were unsuccessful.

Conclusion

This case is in line with previous publications on disseminated non-VHL HB. Available treatment options are inefficient, emphasizing the need for improved understanding of HB biology to identify therapeutic targets.

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Authors and Affiliations

  1. Department of Oncology, Akershus University Hospital, Lørenskog, Norway

    Simer J. Bains

  2. Department of Neuropathology, Oslo University Hospital, Oslo, Norway

    Pitt F. Niehusmann

  3. Department of Neurosurgery, Oslo University Hospital, Oslo, Norway

    Torstein R. Meling & Mark Züchner

  4. Department of Radiology, Oslo University Hospital, Oslo, Norway

    Cathrine Saxhaug

  5. Department of Oncology, Oslo University Hospital, Oslo, Norway

    Petter Brandal

  6. Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway

    Petter Brandal

  7. Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway

    Petter Brandal

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  1. Simer J. Bains
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Correspondence to Simer J. Bains.

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The patient has consented to the writing and submission of the case report. The interpretation and reporting of this case is the sole responsibility of the authors. The case report has been written in accordance with COPE guidelines and comply with the CARE statement. There are no conflicts of interests for any of the contributing authors. No portion of this case report has been presented or published previously.

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Bains, S.J., Niehusmann, P.F., Meling, T.R. et al. Disseminated central nervous system hemangioblastoma in a patient with no clinical or genetic evidence of von Hippel-Lindau disease—a case report and literature review. Acta Neurochir 161, 343–349 (2019). https://doi.org/10.1007/s00701-019-03800-z

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  • DOI: https://doi.org/10.1007/s00701-019-03800-z

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