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Acta Neurochirurgica

, Volume 160, Issue 9, pp 1761–1771 | Cite as

Systematic review and meta-analysis of perioperative and long-term outcomes in patients receiving statin therapy before carotid endarterectomy

  • Natasha IronsideEmail author
  • Daniel Brenner
  • Eric Heyer
  • Ching-Jen Chen
  • Trae Robison
  • Brandon Christophe
  • Edward Sander Connolly
Review Article - Vascular Neurosurgery - Other
Part of the following topical collections:
  1. Vascular Neurosurgery – Other

Abstract

Background

Carotid endarterectomy (CEA) is associated with perioperative stroke and mortality in a minority of cases. The aim of this systematic review and meta-analysis was to investigate the effect of pre-operative statins on perioperative outcomes in patients undergoing CEA for internal carotid artery (ICA) stenosis.

Methods

A systematic review of PubMed, Medline, and the Cochrane Database of Systematic Reviews was performed. Studies were included which reported perioperative stroke and/or survival outcomes following CEA for ICA stenosis and compared patients who were and were not taking pre-operative statins. Relevant data were extracted and pooled using meta-analysis.

Results

Seven studies met the inclusion criteria, comprising 21,387 patients. A total of 68.9% (14,976) were administered statins and 31.1% (6657) were statin-free. Pre-operative statin use was higher in patients with a history of cardiac disease (12.2 vs. 23.6% in the statin-free group), diabetes (31.6 vs. 25.1% in the statin-free group), and hypertension (83.5 vs. 72.2% in the statin-free group), while a greater proportion of statin-free patients had symptomatic disease (44.9 vs. 55.5% in the statin-free group). Statins were associated with reduced perioperative stroke in all patients (OR 0.57; 95% CI 0.34–0.95; p = 0.03) and in symptomatic patients (OR 0.57; 95% CI 0.35–0.93; p = 0.03). A trend towards lower perioperative mortality (OR 0.54; 95% CI 0.29, 1.03; p = 0.06) and significantly improved overall survival was observed in the statin group (HR 0.69; 95% CI 0.59–0.81; p < 0.001) at a mean follow-up of 62 months (range 27–76 months).

Conclusions

Administration of statins before CEA is associated with lower rates of perioperative stroke and improved overall survival. Compliance with optimal medical treatment associated with the use of pre-operative statins may limit the clinical significance of these findings. Future investigation to characterize the potential benefit of statin therapy in patients undergoing CEA for ICA stenosis is warranted.

Keywords

Carotid endarterectomy Statin Survival Outcome Morbidity Mortality 

Notes

Compliance with ethical standards

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Supplementary material

701_2018_3618_MOESM1_ESM.docx (251 kb)
Fig. S1 (DOCX 250 kb)
701_2018_3618_MOESM2_ESM.docx (142 kb)
Fig. S2 (DOCX 141 kb)
701_2018_3618_MOESM3_ESM.docx (15 kb)
Table S1 (DOCX 14 kb)

References

  1. 1.
    O'Regan C, Wu P, Arora P, Perri D, Mills EJ (2008) Statin therapy in stroke prevention: a meta-analysis involving 121,000 patients. Am J Med 121:24–33.  https://doi.org/10.1016/j.amjmed.2007.06.033 CrossRefPubMedGoogle Scholar
  2. 2.
    Taylor F, Huffman MD, Macedo AF, Moore TH, Burke M, Davey Smith G, Ward K, Ebrahim S (2013) Statins for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev CD004816.  https://doi.org/10.1002/14651858.CD004816.pub5
  3. 3.
    Coutts SB, Wein TH, Lindsay MP, Buck B, Cote R, Ellis P, Foley N, Hill MD, Jaspers S, Jin AY, Kwiatkowski B, MacPhail C, McNamara-Morse D, McMurtry MS, Mysak T, Pipe A, Silver K, Smith EE, Gubitz G, Heart, Stroke Foundation Canada Canadian Stroke Best Practices Advisory C (2015) Canadian stroke best practice recommendations: secondary prevention of stroke guidelines, update 2014. Int J Stroke 10:282–291.  https://doi.org/10.1111/ijs.12439 CrossRefPubMedGoogle Scholar
  4. 4.
    Kernan WN, Ovbiagele B, Black HR, Bravata DM, Chimowitz MI, Ezekowitz MD, Fang MC, Fisher M, Furie KL, Heck DV, Johnston SC, Kasner SE, Kittner SJ, Mitchell PH, Rich MW, Richardson D, Schwamm LH, Wilson JA, American Heart Association Stroke Council CoC, Stroke Nursing CoCC, Council on Peripheral Vascular D (2014) Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 45:2160–2236.  https://doi.org/10.1161/STR.0000000000000024 CrossRefPubMedGoogle Scholar
  5. 5.
    Balakumar P, Kathuria S, Taneja G, Kalra S, Mahadevan N (2012) Is targeting eNOS a key mechanistic insight of cardiovascular defensive potentials of statins? J Mol Cell Cardiol 52:83–92.  https://doi.org/10.1016/j.yjmcc.2011.09.014 CrossRefPubMedGoogle Scholar
  6. 6.
    Kalinowski L, Dobrucki IT, Malinski T (2002) Cerivastatin potentiates nitric oxide release and enos expression through inhibition of isoprenoids synthesis. J Physiol Pharmacol 53:585–595PubMedGoogle Scholar
  7. 7.
    Kalinowski L, Dobrucki LW, Brovkovych V, Malinski T (2002) Increased nitric oxide bioavailability in endothelial cells contributes to the pleiotropic effect of cerivastatin. Circulation 105:933–938CrossRefPubMedGoogle Scholar
  8. 8.
    Zhou Q, Liao JK (2010) Pleiotropic effects of statins—basic research and clinical perspectives. Circ J 74:818–826CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Carloni S, Girelli S, Buonocore G, Longini M, Balduini W (2009) Simvastatin acutely reduces ischemic brain damage in the immature rat via Akt and CREB activation. Exp Neurol 220:82–89.  https://doi.org/10.1016/j.expneurol.2009.07.026 CrossRefPubMedGoogle Scholar
  10. 10.
    Kawashima S, Yamashita T, Miwa Y, Ozaki M, Namiki M, Hirase T, Inoue N, Hirata K, Yokoyama M (2003) HMG-CoA reductase inhibitor has protective effects against stroke events in stroke-prone spontaneously hypertensive rats. Stroke 34:157–163CrossRefPubMedGoogle Scholar
  11. 11.
    Laufs U, Gertz K, Dirnagl U, Bohm M, Nickenig G, Endres M (2002) Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice. Brain Res 942:23–30CrossRefPubMedGoogle Scholar
  12. 12.
    Prinz V, Laufs U, Gertz K, Kronenberg G, Balkaya M, Leithner C, Lindauer U, Endres M (2008) Intravenous rosuvastatin for acute stroke treatment: an animal study. Stroke 39:433–438.  https://doi.org/10.1161/STROKEAHA.107.492470 CrossRefPubMedGoogle Scholar
  13. 13.
    Sironi L, Cimino M, Guerrini U, Calvio AM, Lodetti B, Asdente M, Balduini W, Paoletti R, Tremoli E (2003) Treatment with statins after induction of focal ischemia in rats reduces the extent of brain damage. Arterioscler Thromb Vasc Biol 23:322–327CrossRefPubMedGoogle Scholar
  14. 14.
    Barnett HJ, Taylor DW, Eliasziw M, Fox AJ, Ferguson GG, Haynes RB, Rankin RN, Clagett GP, Hachinski VC, Sackett DL, Thorpe KE, Meldrum HE, Spence JD (1998) Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. North American symptomatic carotid Endarterectomy trial collaborators. N Engl J Med 339:1415–1425.  https://doi.org/10.1056/NEJM199811123392002 CrossRefPubMedGoogle Scholar
  15. 15.
    Mayberg MR, Winn HR (1995) Endarterectomy for asymptomatic carotid artery stenosis. Resolving the controversy. JAMA 273:1459–1461CrossRefPubMedGoogle Scholar
  16. 16.
    Mohammed N, Anand SS (2005) Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomized controlled trial. MRC asymptomatic carotid surgery trial (ACST) collaborative group. Lancet 2004; 363: 1491-1502. Vasc Med 10:77–78. doi: https://doi.org/10.1191/1358863x05vm588xx
  17. 17.
    No Authors (1991) MRC European carotid surgery trial: interim results for symptomatic patients with severe (70-99%) or with mild (0-29%) carotid stenosis. European Carotid Surgery Trialists' Collaborative Group. Lancet 337:1235–1243CrossRefGoogle Scholar
  18. 18.
    Babu MA, Meissner I, Meyer FB (2013) The durability of carotid endarterectomy: long-term results for restenosis and stroke. Neurosurgery 72:835–838; discussion 838-839; quiz 839.  https://doi.org/10.1227/NEU.0b013e31828a7e30 CrossRefPubMedGoogle Scholar
  19. 19.
    Brott TG, Howard G, Roubin GS, Meschia JF, Mackey A, Brooks W, Moore WS, Hill MD, Mantese VA, Clark WM, Timaran CH, Heck D, Leimgruber PP, Sheffet AJ, Howard VJ, Chaturvedi S, Lal BK, Voeks JH, Hobson RW 2nd, Investigators C (2016) Long-term results of stenting versus endarterectomy for carotid-artery stenosis. N Engl J Med 374:1021–1031.  https://doi.org/10.1056/NEJMoa1505215 CrossRefPubMedPubMedCentralGoogle Scholar
  20. 20.
    Mukerji N, Manjunath Prasad KS, Vivar R, Mendelow AD (2015) Carotid endarterectomy-safe and effective in a neurosurgeon's hands: a 25-year single-surgeon experience. World Neurosurg 83:74–79.  https://doi.org/10.1016/j.wneu.2013.02.088 CrossRefPubMedGoogle Scholar
  21. 21.
    Spangler EL, Goodney PP, Schanzer A, Stone DH, Schermerhorn ML, Powell RJ, Cronenwett JL, Nolan BW, Vascular Study Group of New E (2014) Outcomes of carotid endarterectomy versus stenting in comparable medical risk patients. J Vasc Surg 60:1227–1231.  https://doi.org/10.1016/j.jvs.2014.05.044 CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    Chan RC, Chan YC, Cheung GC, Cheng SW (2014) Predictors of restenosis after carotid endarterectomy: 17-year experience in a tertiary referral vascular center. Vasc Endovasc Surg 48:201–206.  https://doi.org/10.1177/1538574413518117 CrossRefGoogle Scholar
  23. 23.
    Lal BK, Beach KW, Roubin GS, Lutsep HL, Moore WS, Malas MB, Chiu D, Gonzales NR, Burke JL, Rinaldi M, Elmore JR, Weaver FA, Narins CR, Foster M, Hodgson KJ, Shepard AD, Meschia JF, Bergelin RO, Voeks JH, Howard G, Brott TG, Investigators C (2012) Restenosis after carotid artery stenting and endarterectomy: a secondary analysis of CREST, a randomised controlled trial. Lancet Neurol 11:755–763.  https://doi.org/10.1016/S1474-4422(12)70159-X CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    Sanders RD, Nicholson A, Lewis SR, Smith AF, Alderson P (2013) Perioperative statin therapy for improving outcomes during and after noncardiac vascular surgery. Cochrane Database Syst Rev:CD009971. doi: https://doi.org/10.1002/14651858.CD009971.pub2
  25. 25.
    AbuRahma AF, Srivastava M, Stone PA, Richmond BK, AbuRahma Z, Jackson W, Dean LS, Mousa AY (2015) Effect of statins on early and late clinical outcomes of carotid endarterectomy and the rate of post-carotid endarterectomy restenosis. J Am Coll Surg 220:481–487.  https://doi.org/10.1016/j.jamcollsurg.2014.12.011 CrossRefPubMedGoogle Scholar
  26. 26.
    Avgerinos ED, Kakisis JD, Moulakakis KG, Giannakopoulos TG, Sfyroeras G, Antonopoulos CN, Kadoglou NP, Liapi CD (2015) Statins influence long term restenosis and cardiovascular events following carotid endarterectomy. Curr Vasc Pharmacol 13:239–247CrossRefPubMedGoogle Scholar
  27. 27.
    Ballotta E, Toniato A, Farina F, Baracchini C (2017) Effects of preoperative statin use on perioperative outcomes of carotid endarterectomy. Brain Behav 7:e00597.  https://doi.org/10.1002/brb3.597 CrossRefPubMedGoogle Scholar
  28. 28.
    Krafcik BM, Farber A, Eberhardt RT, Kalish JA, Rybin D, Doros G, Pike SL, Siracuse JJ (2018) Preoperative antiplatelet and statin use does not affect outcomes after carotid endarterectomy. Ann Vasc Surg 46:43–52.  https://doi.org/10.1016/j.avsg.2017.10.002 CrossRefPubMedGoogle Scholar
  29. 29.
    Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA, Group P-P (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev 4(1).  https://doi.org/10.1186/2046-4053-4-1
  30. 30.
    Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA 283:2008–2012CrossRefPubMedGoogle Scholar
  31. 31.
    Downs SH, Black N (1998) The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health 52:377–384CrossRefPubMedPubMedCentralGoogle Scholar
  32. 32.
    Tierney JF, Stewart LA, Ghersi D, Burdett S, Sydes MR (2007) Practical methods for incorporating summary time-to-event data into meta-analysis. Trials 8:16.  https://doi.org/10.1186/1745-6215-8-16 CrossRefPubMedPubMedCentralGoogle Scholar
  33. 33.
    Heyer EJ, Mergeche JL, Wang S, Gaudet JG, Connolly ES (2015) Impact of cognitive dysfunction on survival in patients with and without statin use following carotid endarterectomy. Neurosurgery 77:880–887.  https://doi.org/10.1227/NEU.0000000000000904 CrossRefPubMedGoogle Scholar
  34. 34.
    Kennedy J, Quan H, Buchan AM, Ghali WA, Feasby TE (2005) Statins are associated with better outcomes after carotid endarterectomy in symptomatic patients. Stroke 36:2072–2076.  https://doi.org/10.1161/01.STR.0000183623.28144.32 CrossRefPubMedGoogle Scholar
  35. 35.
    McGirt MJ, Perler BA, Brooke BS, Woodworth GF, Coon A, Jain S, Buck D, Roseborough GS, Tamargo RJ, Heller J, Freischlag JA, Williams GM (2005) 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors reduce the risk of perioperative stroke and mortality after carotid endarterectomy. J Vasc Surg 42:829–836; discussion 836-827.  https://doi.org/10.1016/j.jvs.2005.08.039 CrossRefPubMedGoogle Scholar
  36. 36.
    Ackerstaff RG, Moons KG, van de Vlasakker CJ, Moll FL, Vermeulen FE, Algra A, Spencer MP (2000) Association of intraoperative transcranial Doppler monitoring variables with stroke from carotid endarterectomy. Stroke 31:1817–1823Google Scholar
  37. 37.
    Levi CR, O'Malley HM, Fell G, Roberts AK, Hoare MC, Royle JP, Chan A, Beiles BC, Chambers BR, Bladin CF, Donnan GA (1997) Transcranial Doppler detected cerebral microembolism following carotid endarterectomy. High microembolic signal loads predict postoperative cerebral ischaemia. Brain 120(Pt 4):621–629CrossRefPubMedGoogle Scholar
  38. 38.
    Spencer MP (1997) Transcranial Doppler monitoring and causes of stroke from carotid endarterectomy. Stroke 28:685–691CrossRefPubMedGoogle Scholar
  39. 39.
    Katsargyris A, Klonaris C, Tsiodras S, Bastounis E, Giannopoulos A, Theocharis S (2011) Statin treatment is associated with reduced toll-like receptor 4 immunohistochemical expression on carotid atherosclerotic plaques: a novel effect of statins. Vascular 19:320–326.  https://doi.org/10.1258/vasc.2011.oa0306 CrossRefPubMedGoogle Scholar
  40. 40.
    Koutouzis M, Nomikos A, Nikolidakis S, Tzavara V, Andrikopoulos V, Nikolaou N, Barbatis C, Kyriakides ZS (2007) Statin treated patients have reduced intraplaque angiogenesis in carotid endarterectomy specimens. Atherosclerosis 192:457–463.  https://doi.org/10.1016/j.atherosclerosis.2007.01.035 CrossRefPubMedGoogle Scholar
  41. 41.
    Molloy KJ, Thompson MM, Schwalbe EC, Bell PR, Naylor AR, Loftus IM (2004) Comparison of levels of matrix metalloproteinases, tissue inhibitor of metalloproteinases, interleukins, and tissue necrosis factor in carotid endarterectomy specimens from patients on versus not on statins preoperatively. Am J Cardiol 94:144–146.  https://doi.org/10.1016/j.amjcard.2004.03.050 CrossRefPubMedGoogle Scholar
  42. 42.
    Puato M, Faggin E, Rattazzi M, Zambon A, Cipollone F, Grego F, Ganassin L, Plebani M, Mezzetti A, Pauletto P (2010) Atorvastatin reduces macrophage accumulation in atherosclerotic plaques: a comparison of a nonstatin-based regimen in patients undergoing carotid endarterectomy. Stroke 41:1163–1168.  https://doi.org/10.1161/STROKEAHA.110.580811 CrossRefPubMedGoogle Scholar
  43. 43.
    Bicknell CD, Cowling MG, Clark MW, Delis KT, Jenkins MP, Hughes AD, Thom SA, Wolfe JH, Cheshire NJ (2003) Carotid angioplasty in a pulsatile flow model: factors affecting embolic potential. Eur J Vasc Endovasc Surg 26:22–31CrossRefPubMedGoogle Scholar
  44. 44.
    Heyer EJ, Mergeche JL, Bruce SS, Ward JT, Stern Y, Anastasian ZH, Quest DO, Solomon RA, Todd GJ, Benvenisty AI, McKinsey JF, Nowygrod R, Morrissey NJ, Connolly ES (2013) Statins reduce neurologic injury in asymptomatic carotid endarterectomy patients. Stroke 44:1150–1152.  https://doi.org/10.1161/STROKEAHA.111.000362 CrossRefPubMedPubMedCentralGoogle Scholar
  45. 45.
    Mocco J, Wilson DA, Komotar RJ, Zurica J, Mack WJ, Halazun HJ, Hatami R, Sciacca RR, Connolly ES Jr, Heyer EJ (2006) Predictors of neurocognitive decline after carotid endarterectomy. Neurosurgery 58:844–850; discussion 844-850.  https://doi.org/10.1227/01.NEU.0000209638.62401.7E CrossRefPubMedPubMedCentralGoogle Scholar
  46. 46.
    Wilson DA, Mocco J, D'Ambrosio AL, Komotar RJ, Zurica J, Kellner CP, Hahn DK, Connolly ES, Liu X, Imielinska C, Heyer EJ (2008) Post-carotid endarterectomy neurocognitive decline is associated with cerebral blood flow asymmetry on post-operative magnetic resonance perfusion brain scans. Neurol Res 30:302–306.  https://doi.org/10.1179/016164107X230540 CrossRefPubMedGoogle Scholar
  47. 47.
    Gaudet JG, Yocum GT, Lee SS, Granat A, Mikami M, Connolly ES Jr, Heyer EJ (2010) MMP-9 levels in elderly patients with cognitive dysfunction after carotid surgery. J Clin Neurosci 17:436–440.  https://doi.org/10.1016/j.jocn.2009.07.103 CrossRefPubMedPubMedCentralGoogle Scholar
  48. 48.
    Heyer EJ, Mergeche JL, Bruce SS, Connolly ES (2013) Does cognitive dysfunction after carotid endarterectomy vary by statin type or dose? Int J Brain Cogn Sci 2:57–62PubMedPubMedCentralGoogle Scholar
  49. 49.
    Hillis LD, Smith PK, Anderson JL, Bittl JA, Bridges CR, Byrne JG, Cigarroa JE, VJ DS, Hiratzka LF, Hutter AM Jr, Jessen ME, Keeley EC, Lahey SJ, Lange RA, London MJ, Mack MJ, Patel MR, Puskas JD, Sabik JF, Selnes O, Shahian DM, Trost JC, Winniford MD, Jacobs AK, Anderson JL, Albert N, Creager MA, Ettinger SM, Guyton RA, Halperin JL, Hochman JS, Kushner FG, Ohman EM, Stevenson W, Yancy CW, American College of Cardiology Foundation/American Heart Association Task Force on Practice G (2012) 2011 ACCF/AHA guideline for coronary artery bypass graft surgery: executive summary: a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines. J Thorac Cardiovasc Surg 143:4–34.  https://doi.org/10.1016/j.jtcvs.2011.10.015 CrossRefPubMedGoogle Scholar
  50. 50.
    Kolh P, Windecker S, Alfonso F, Collet JP, Cremer J, Falk V, Filippatos G, Hamm C, Head SJ, Juni P, Kappetein AP, Kastrati A, Knuuti J, Landmesser U, Laufer G, Neumann FJ, Richter DJ, Schauerte P, Sousa Uva M, Stefanini GG, Taggart DP, Torracca L, Valgimigli M, Wijns W, Witkowski A, European Society of Cardiology Committee for Practice G, Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S, Committee ECG, Sousa Uva M, Achenbach S, Pepper J, Anyanwu A, Badimon L, Bauersachs J, Baumbach A, Beygui F, Bonaros N, De Carlo M, Deaton C, Dobrev D, Dunning J, Eeckhout E, Gielen S, Hasdai D, Kirchhof P, Luckraz H, Mahrholdt H, Montalescot G, Paparella D, Rastan AJ, Sanmartin M, Sergeant P, Silber S, Tamargo J, ten Berg J, Thiele H, van Geuns RJ, Wagner HO, Wassmann S, Wendler O, Zamorano JL, Task Force on Myocardial Revascularization of the European Society of C, the European Association for Cardio-Thoracic S, European Association of Percutaneous Cardiovascular I (2014) 2014 ESC/EACTS guidelines on myocardial revascularization: the task force on myocardial revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur J Cardiothorac Surg 46:517–592.  https://doi.org/10.1093/ejcts/ezu366 CrossRefPubMedGoogle Scholar
  51. 51.
    Patti G, Pasceri V, Colonna G, Miglionico M, Fischetti D, Sardella G, Montinaro A, Di Sciascio G (2007) Atorvastatin pretreatment improves outcomes in patients with acute coronary syndromes undergoing early percutaneous coronary intervention: results of the ARMYDA-ACS randomized trial. J Am Coll Cardiol 49:1272–1278.  https://doi.org/10.1016/j.jacc.2007.02.025 CrossRefPubMedGoogle Scholar
  52. 52.
    Wassmann S, Faul A, Hennen B, Scheller B, Bohm M, Nickenig G (2003) Rapid effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition on coronary endothelial function. Circ Res 93:e98–e103.  https://doi.org/10.1161/01.RES.0000099503.13312.7B
  53. 53.
    Eckstein HH, Ringleb P, Allenberg JR, Berger J, Fraedrich G, Hacke W, Hennerici M, Stingele R, Fiehler J, Zeumer H, Jansen O (2008) Results of the stent-protected angioplasty versus carotid endarterectomy (SPACE) study to treat symptomatic stenoses at 2 years: a multinational, prospective, randomised trial. Lancet Neurol 7:893–902.  https://doi.org/10.1016/S1474-4422(08)70196-0 CrossRefPubMedGoogle Scholar
  54. 54.
    Amarenco P, Bogousslavsky J, Callahan A, 3rd, Goldstein LB, Hennerici M, Rudolph AE, Sillesen H, Simunovic L, Szarek M, Welch KM, Zivin JA, Stroke prevention by aggressive reduction in cholesterol levels I (2006) High-dose atorvastatin after stroke or transient ischemic attack N Engl J Med 355:549–559. doi: https://doi.org/10.1056/NEJMoa061894
  55. 55.
    Hobson RW, II MWC, Ascher E, Murad MH, Calligaro KD, Comerota AJ, Montori VM, Eskandari MK, Massop DW, Bush RL, Lal BK, Perler BA, Society for Vascular S (2008) Management of atherosclerotic carotid artery disease: clinical practice guidelines of the Society for Vascular Surgery. J Vasc Surg 48:480–486.  https://doi.org/10.1016/j.jvs.2008.05.036 CrossRefPubMedGoogle Scholar
  56. 56.
    Brott TG, Hobson RW 2nd, Howard G, Roubin GS, Clark WM, Brooks W, Mackey A, Hill MD, Leimgruber PP, Sheffet AJ, Howard VJ, Moore WS, Voeks JH, Hopkins LN, Cutlip DE, Cohen DJ, Popma JJ, Ferguson RD, Cohen SN, Blackshear JL, Silver FL, Mohr JP, Lal BK, Meschia JF, Investigators C (2010) Stenting versus endarterectomy for treatment of carotid-artery stenosis. N Engl J Med 363:11–23.  https://doi.org/10.1056/NEJMoa0912321 CrossRefPubMedPubMedCentralGoogle Scholar
  57. 57.
    Rosenfield K, Matsumura JS, Chaturvedi S, Riles T, Ansel GM, Metzger DC, Wechsler L, Jaff MR, Gray W, Investigators AI (2016) Randomized trial of stent versus surgery for asymptomatic carotid stenosis. N Engl J Med 374:1011–1020.  https://doi.org/10.1056/NEJMoa1515706 CrossRefPubMedGoogle Scholar
  58. 58.
    Howard VJ, Voeks JH, Lutsep HL, Mackey A, Milot G, Sam AD 2nd, Tom M, Hughes SE, Sheffet AJ, Longbottom M, Avery JB, Hobson RW 2nd, Brott TG (2009) Does sex matter? Thirty-day stroke and death rates after carotid artery stenting in women versus men: results from the carotid revascularization Endarterectomy versus stenting trial (CREST) lead-in phase. Stroke 40:1140–1147.  https://doi.org/10.1161/STROKEAHA.108.541847 CrossRefPubMedPubMedCentralGoogle Scholar
  59. 59.
    Voeks JH, Howard G, Roubin GS, Malas MB, Cohen DJ, Sternbergh WC III, Aronow HD, Eskandari MK, Sheffet AJ, Lal BK, Meschia JF, Brott TG, Investigators C (2011) Age and outcomes after carotid stenting and endarterectomy: the carotid revascularization endarterectomy versus stenting trial. Stroke 42:3484–3490.  https://doi.org/10.1161/STROKEAHA.111.624155 CrossRefPubMedPubMedCentralGoogle Scholar
  60. 60.
    Nakagawa I, Park HS, Yokoyama S, Wada T, Yamada S, Motoyama Y, Kichikawa K, Nakase H (2017) Pretreatment with and ongoing use of omega-3 fatty acid ethyl esters reduce the slow-flow phenomenon and prevent in-stent restenosis in patients undergoing carotid artery stenting. J Vasc Surg 66:122–129.  https://doi.org/10.1016/j.jvs.2016.12.132 CrossRefPubMedGoogle Scholar
  61. 61.
    Reiff T, Amiri H, Rohde S, Hacke W, Ringleb PA (2014) Statins reduce peri-procedural complications in carotid stenting. Eur J Vasc Endovasc Surg 48:626–632.  https://doi.org/10.1016/j.ejvs.2014.08.010 CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Neurological SurgeryColumbia University Medical CenterNew YorkUSA
  2. 2.Department of Neurological SurgeryUniversity of Virginia Health SystemCharlottesvilleUSA

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