Response to the letter to the editor Systemic inflammatory response in pediatric central nervous system tumors
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We sought to address the issue of potential confounding factors in the original article, stating that we had taken every possible step to exclude the influence of medication/steroids that may affect the values of the neutrophil-lymphocyte count ratio (NLCR). Since this was a retrospective study, there was no capacity to request additional inflammatory marker or hormonal testing on the original blood samples for each patient. The measurement of cortisol levels in the UK is not considered routine standard practice in the initial clinical assessment of children with neurological disease, and therefore, there is no capacity for this to be included in our study. However, we recognize the point made in...
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