Acta Neurochirurgica

, Volume 160, Issue 3, pp 651–654 | Cite as

Intraoperative intravenous fluorescein as an adjunct during surgery for peroneal intraneural ganglion cysts

  • Jonathan J. Stone
  • Christopher S. Graffeo
  • Godard C.W. de Ruiter
  • Michael G. Rock
  • Robert J. Spinner
Technical Note - Peripheral Nerves


The intraoperative use of intravenous fluorescein is presented in a case of peroneal intraneural ganglion cyst. When illuminated with the operative microscope and yellow filter, this fluorophore provided excellent visualization of the abnormal cystic peroneal nerve and its articular branch connection. The articular (synovial) theory for the pathogenesis of intraneural cysts is further supported by this pattern of fluorescence. Further, our report presents a novel use of fluorescein in peripheral nerve surgery.


Peripheral nerve Peroneal nerve Intraneural ganglion cyst Articular branch Fluorescein 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional committee (Mayo Clinic Institutional Review Board) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.


For this type of study, formal consent was not required.


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Jonathan J. Stone
    • 1
  • Christopher S. Graffeo
    • 1
  • Godard C.W. de Ruiter
    • 2
  • Michael G. Rock
    • 3
  • Robert J. Spinner
    • 1
  1. 1.Department of Neurologic SurgeryMayo ClinicRochesterUSA
  2. 2.Department of NeurosurgeryHague Medical CenterThe HagueThe Netherlands
  3. 3.Department of Orthopedic SurgeryMayo ClinicRochesterUSA

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