3D flower-liked Fe3O4/C for highly sensitive magnetic dispersive solid-phase extraction of four trace non-steroidal anti-inflammatory drugs


A low cost-effective and simple synthesis method was adopted to acquire three-dimensional flower-like structure Fe3O4/C that has large specific area, suitable pore structure and sufficient saturation magnetism. The obtained Fe3O4/C exhibits outstanding preconcentration ability and was applied to extracting non-steroidal anti-inflammatory drugs from complex environmental and biological samples. The parameters of magnetic solid-phase extraction were optimized by univariate and multivariate methods (Box-Behnken design). The high degree of linearity from 2.5 to 1000.0 ng mL−1 (R2 ≥ 0.9976), the limits of detection from 0.25 to 0.5 ng mL- 1 (S/N = 3), and the limits of quantitation from 1.0 to 2.0 ng mL- 1 (S/N = 10) were yielded by adopting this novel method after the optimization. Moreover, the recoveries of non-steroidal anti-inflammatory drugs from 89.6 to 107.0% were acquired in spiked plasma, urine and lake samples. In addition, the adsorption of non-steroidal anti-inflammatory drugs on Fe3O4/C was explored by adsorption isotherms and kinetic studies. Furthermore, the adsorption mechanism for non-steroidal anti-inflammatory drugs by Fe3O4/C was proposed, which was hydrogen bonding and π-π interaction between non-steroidal anti-inflammatory drugs and Fe3O4/C.

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This work was supported by the Science and Technology Foundation of Ocean and Fisheries of Liaoning Province (No. 201408, No. 201406), Liaoning Provincial Doctor Startup Fund Program (No. 201601092), the General project of scientific research of the Education Department of Liaoning Province (No. LQN201707), Liaoning Provincial Natural Science Fund Guidance Project (20180550928) and the Foundation for National Advance declaration of Liaoning University (No. LDGY201406).

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Xu, X., Feng, X., Liu, Z. et al. 3D flower-liked Fe3O4/C for highly sensitive magnetic dispersive solid-phase extraction of four trace non-steroidal anti-inflammatory drugs. Microchim Acta 188, 52 (2021). https://doi.org/10.1007/s00604-021-04708-1

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  • 3D flower-like structure
  • Fe3O4/C
  • Magnetic solid-phase extraction
  • NSAIDs
  • Environmental and biological samples