An electrochemical sensor for ifosfamide, acetaminophen, domperidone, and sumatriptan based on self-assembled MXene/MWCNT/chitosan nanocomposite thin film


New multi-walled carbon nanotubes supported on Ti3C2–MXene and chitosan (chit) composite film–based electrochemical sensor for ifosfamide (IFO), acetaminophen (ACOP), domperidone (DOM), and sumatriptan (SUM) have been developed. Ti3C2–MXene was synthesized by a fluoride method. Structural and chemical characterizations suggested the successful preparation of Ti3C2–MXene with clearly seen layered morphology, defined 0 0 2 diffraction peak at 7.5° and complete absence of 1 0 4 plane at 39°. The electrochemical performance of the sensor was investigated by cyclic voltammetry and adsorptive stripping differential pulse voltammetry. The Ti3C2/MWCNT/Chit modified glassy carbon electrode exhibits enhanced electrocatalytic activities toward the oxidation of target analytes. Excellent conductivity, large surface area, and high catalytic properties of the Ti3C2–MXene showed synergistic effects with MWCNTs and helped in achieving low detection limits of targets with high selectivity and reproducibility. The assay allows determination of IFO, ACOP, DOM, and SUM in the concentration ranges 0.0011–1.0, 0.0042–7.1, 0.0046–7.3, and 0.0033–61 μM with low detection limits of 0.00031, 0.00028, 0.00034, and 0.00042 μM, respectively. The sensor was successfully applied for voltammetric screening of target analytes in urine and blood serum samples with recoveries > 95.21%. Schematic illustration of the synthesis of self-assembled MXene/MWCNT/chitosan nanocomposite is given and its application to the voltammetric determination of ifosfamide, acetaminophen, domperidone, and sumatriptan described.

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Authors thank the Analytical and Testing Centre and State Key Laboratory of Materials Processing and Die & Mold Technology of HUST for providing SEM, XPS, and XRD measurements.


This work was supported by the National Natural Science Foundation of China (Grant Nos. 51672098 and 51632001).

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Correspondence to Yunhui Huang.

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Kalambate, P.K., Dhanjai, Sinha, A. et al. An electrochemical sensor for ifosfamide, acetaminophen, domperidone, and sumatriptan based on self-assembled MXene/MWCNT/chitosan nanocomposite thin film. Microchim Acta 187, 402 (2020).

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  • Electrochemical analysis
  • Stripping voltammetry
  • Modified electrodes
  • 2D materials
  • Functionalized carbon nanotubes
  • Biopolymer
  • Multi-drug analysis
  • Anticancer drugs