A flower-like Fe3O4/GO/CdSe nanodot magnetic hybrid material was produced and applied to magnetic solid-phase extraction of ibuprofen from pharmaceuticals, water, and urine samples. The material was characterized by X-ray diffraction, Raman spectroscopy and field emission scanning electron microscopy and SEM-EDX. The pH value, volume of sample solution, amount of sorbent, type and volume of elution solvent and extraction time were optimized. Following elution with acetone, ibuprofen was quantified by HPLC-DAD detection. The recoveries of ibuprofen from spiked real samples ranged between 87 and 109%, and the intra-day and inter-day relative standard deviations from 1.25 to 3.02%. The limit of detection, limit of quantification and preconcentration factor are 0.36 ng·mL−1,1.20 ng·mL−1 and 150, respectively.
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Ghorbani M, Chamsaz M, Rounaghi GH (2016) Ultrasound-assisted magnetic dispersive solid-phase microextraction: A novel approach for the rapid and efficient microextraction of naproxen and ibuprofen employing experimental design with high performance liquid chromatography. J Sep Sci 39(6):1082–1089
Scheytt T, Mersmann P, Lindstädt R, Heberer T (2005) Determination of sorption coefficients of pharmaceutically active substances carbamazepine, diclofenac, and ibuprofen, in sandy sediments. Chemosphere 60(2):245–253
Wang Z, Srivastava V, Ambat I, Safaei Z, Sillanpää M (2019) Degradation of ibuprofen by UV-LED/catalytic advanced oxidation process. J Water Proc Eng 31:100808
Wolecki D, Caban M, Pazdro K, Mulkiewicz E, Stepnowski P, Kumirska J (2019) Simultaneous determination of non-steroidal anti-inflammatory drugs and natural estrogens in the mussels Mytilus edulis trossulus. Talanta 200:316–323
Ghani M, Ghoreishi SM, Salehinia S, Mousavi N, Ansarinejad H (2019) Electrochemically decorated network-like cobalt oxide nanosheets on nickel oxide nanoworms substrate as a sorbent for the thin film microextraction of diclofenac. Microchem J146:149–156
Wang T, Liu S, Gao G, Zhao P, Lu N, Lun X, Hou X (2017) Magnetic solid phase extraction of non-steroidal anti-inflammatory drugs from water samples using a metal organic framework of type Fe3O4/MIL-101 (Cr), and their quantitation by UPLC-MS/MS. Microchim Acta 184(8):2981–2990
Whelan MR, Ford JL, Powell MW (2002) Simultaneous determination of ibuprofen and hydroxypropylmethylcellulose (HPMC) using HPLC and evaporative light scattering detection. J Pharma Biomed 30(4):1355–1359
Vinci F, Fabbrocino S, Fiori M, Serpe L, Gallo P (2006) Determination of fourteen non-steroidal anti-inflammatory drugs in animal serum and plasma by liquid chromatography/mass spectrometry. Rapid Commun Mass Spectrom 20(22):3412–3420
Araujo L, Wild J, Villa N, Camargo N, Cubillan D, Prieto A (2008) Determination of anti-inflammatory drugs in water samples, by in situ derivatization, solid phase microextraction and gas chromatography–mass spectrometry. Talanta 75(1):111–115
Lpez-Bojrquez E, Castaeda-Hernndez G, Parra MGDL, Namur S (2008) Development and validation of a high-performance thin-layer chromatographic method, with densitometry, for quantitative analysis of ketorolac tromethamine in human plasma. J AOAC Int 91(5):1191–1195
Macià A, Borrull F, Calull M, Aguilar C (2007) Capillary electrophoresis for the analysis of non-steroidal anti-inflammatory drugs. TrAC Trend Anal Chem 26(2):133–153
Kormosh Z, Hunka I, Bazel Y, Matviychuk O (2010) Potentiometric determination of ketoprofen and piroxicam at a new PVC electrode based on ion associates of Rhodamine 6G. Mat Sci Eng C-Mater 30(7):997–1002
Shishov AY, Chislov MV, Nechaeva DV, Moskvin LN, Bulatov AV (2018) A new approach for microextraction of non-steroidal anti-inflammatory drugs from human urine samples based on in-situ deep eutectic mixture formation. J Mol Liq 272:738–745
Mafra G, Spudeit D, Brognoli R, Merib J, Carasek E (2018) Expanding the applicability of cork as extraction phase for disposable pipette extraction in multiresidue analysis of pharmaceuticals in urine samples. J Chromatogr B 1102:159–166
Li Y, Liao Y, Huang Y, Ye Z, Huang X (2019) Dual functional monomers modified magnetic adsorbent for the enrichment of non-steroidal anti-inflammatory drugs in water and urine samples. Talanta 201:496–502
Wang Y, Jia M, Wu X, Wang T, Wang J, Hou X (2019) PEG modified column MIL-101 (Cr)/PVA cryogel as a sorbent in stir bar solid phase extraction for determination of non-steroidal anti-inflammatory drugs in water samples. Microchem J 146:214–219
Khan M, Yilmaz E, Soylak M (2016) Vortex assisted magnetic solid phase extraction of lead (II) and cobalt (II) on silica coated magnetic multiwalled carbon nanotubes impregnated with 1-(2-pyridylazo)-2-naphthol. J Mol Liq 224:639–647
Hu B, He M, Chen B (2015) Nanometer-sized materials for solid-phase extraction of trace elements. Anal Bioanal Chem 407(10):2685–2710
Molaei R, Tajik H, Moradi M (2019) Magnetic solid phase extraction based on mesoporous silica-coated iron oxide nanoparticles for simultaneous determination of biogenic amines in an Iranian traditional dairy product; Kashk. Food Control 101:1–8
Yilmaz E, Ulusoy H. İ, Demir Ö, Soylak, M (2018). A new magnetic nanodiamond/graphene oxide hybrid (Fe3O4@ ND@ GO) material for pre-concentration and sensitive determination of sildenafil in alleged herbal aphrodisiacs by HPLC-DAD system. J Chromatogr B 1084:113–121
Herrero-Latorre C, Barciela-García J, García-Martín S, Peña-Crecente RM, Otárola-Jiménez J (2015) Magnetic solid-phase extraction using carbon nanotubes as sorbents: a review. Anal Chim Acta 892:10–26
Scida K, Stege PW, Haby G, Messina GA, García CD (2011) Recent applications of carbon-based nanomaterials in analytical chemistry: critical review. Anal Chim Acta 691(1–2):6–17
Liu Q, Shi J, Jiang G (2012) Application of graphene in analytical sample preparation. TrAC Trend Anal Chem 37:1–11
Yilmaz E, Soylak M (2017) Facile and green solvothermal synthesis of palladium nanoparticle-nanodiamond-graphene oxide material with improved bifunctional catalytic properties. J Iran Chem Soc 14(12):2503–2512
Ulusoy Hİ, Yılmaz E, Soylak M (2019) Magnetic solid phase extraction of trace paracetamol and caffeine in synthetic urine and wastewater samples by a using core shell hybrid material consisting of graphene oxide/multiwalled carbon nanotube/Fe3O4/SiO2. Microchem J 145:843–851
Zeinali S, Maleki M, Bagheri H (2019) Amine modified magnetic polystyrene for extraction of drugs from urine samples. J Chromatogr A 1602:107–116
Ali I, Kulsum U, Al-Othman ZA, Saleem K (2016) Analyses of nonsteroidal anti-inflammatory drugs in human plasma using dispersive nano solid-phase extraction and high-performance liquid chromatography. Chromatographia 79(3–4):145–157
Amiri A, Mirzaei M, Derakhshanrad S (2019) A nanohybrid composed of polyoxotungstate and graphene oxide for dispersive micro solid-phase extraction of non-steroidal anti-inflammatory drugs prior to their quantitation by HPLC. Microchim Acta 186(8):534
Seidi S, Sanàti SE (2019) Nickel-iron layered double hydroxide nanostructures for micro solid phase extraction of nonsteroidal anti-inflammatory drugs, followed by quantitation by HPLC-UV. Microchim Acta 186(5):297
Jian N, Qian L, Wang C, Li R, Xu Q, Li J (2019) Novel nanofibers mat as an efficient, fast and reusable adsorbent for solid phase extraction of non-steroidal anti-inflammatory drugs in environmental water. J Hazard Mater 363:81–89
Li W, Chen N, Zhu Y, Shou D, Zhi M, Zeng X (2019) A nanocomposite consisting of an amorphous seed and a molecularly imprinted covalent organic framework shell for extraction and HPLC determination of nonsteroidal anti-inflammatory drugs. Microchim Acta 186(2):76
This work has been supported by Erciyes University Scientific Research Projects Coordination Unit with research project FBA-2018-7761.
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Sarp, G., Yilmaz, E. A flower-like hybrid material composed of Fe3O4, graphene oxide and CdSe nanodots for magnetic solid phase extraction of ibuprofen prior to its quantification by HPLC detection. Microchim Acta 186, 744 (2019). https://doi.org/10.1007/s00604-019-3875-x
- Hydrothermal synthesis
- Non-steroidal anti-inflammatory drug
- Urine samples
- Water samples
- Magnetic separation
- Hummers method