Microchimica Acta

, 185:175 | Cite as

Matrix assisted laser desorption/ionization time-of-flight mass spectrometric determination of benzo[a]pyrene using a MIL-101(Fe) matrix

  • Jun-ping Wang
  • Ying Wang
  • Xiaohua Guo
  • Peng Wang
  • Tao Zhao
  • Junying Wang
Original Paper


A method is described for the matrix assisted laser desorption/ionization time-of-flight (MALDI-TOF)-based determination of benzo[a]pyrene (BaP) by using the metal-organic framework MIL-101(Fe) as a matrix. Following optimization of the experimental parameters, the method has a detection limit as low as 0.1 μg·L−1, which makes it more sensitive than previous methods for BaP analysis, and its analysis time is only 1 min. Its applicability was evaluated by analyzing sesame oil, linseed oil, camellia seed oil, and olive oil spiked with BaP at three levels (10, 1, and 0.5 μg·kg−1), and the recovery range was found to range from 80.0 to 114.8% with relative standard deviations (RSDs) between 3.9 and 13.7%.

Graphical abstract

The metal-organic framework MIL-101(Fe) was applied as a new matrix to the quantitative detection of benzo[a]pyrene (BaP) by matrix assisted laser desorption/ionization time-of-flight (MALDI-TOF).


Benzo[a]pyrene Metal-organic framework Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry Vegetable oil 



We would like to thank the National Key R&D Program of China (No. 2016YFD0401202), the Special Fund for Grain-scientific Research in the Public Interest (201513006-04), and the National Key Technology R&D Program (No. 2015BAD17B03).

Author contributions

All authors have given approval to the final version of the manuscript.

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2017_2627_MOESM1_ESM.doc (8.4 mb)
ESM 1 (DOC 8.44 mb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Jun-ping Wang
    • 1
  • Ying Wang
    • 1
  • Xiaohua Guo
    • 1
  • Peng Wang
    • 1
  • Tao Zhao
    • 1
  • Junying Wang
    • 2
  1. 1.Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin Key Laboratory of Food Nutrition and SafetyTianjin University of Science and TechnologyTianjinChina
  2. 2.Biotechnology Research InstituteChinese Academy of Agricultural SciencesBeijingChina

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