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The prognostic relevance of primary tumor sidedness to surgical treatment for recurrent colon cancer

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Abstract

Purpose

The aim of this study was to investigate the predictive relevance of tumor sidedness on surgical resection after recurrence by evaluating the treatment outcomes after primary resection and recurrence in patients with localized colon cancer (CC).

Methods

A total of 735 consecutive patients who underwent curative resection for Stage I–III CC from 1997 to 2013 were categorized as having either right- or left-sided CC, and survival after primary surgery and after recurrence were analyzed.

Results

A total of 104 patients (14.1%) developed recurrence, 94 of which were in a single organ, and 59 patients underwent curative resection. For recurrence from both sides of the colon, a significantly better 5-year overall survival (OS) was experienced by patients who underwent curative resection compared to those who received palliative treatment (right: 42.2% vs not reached, respectively; P < 0.001; left: 71 vs 15.9%, respectively; P < 0.001). Meanwhile, a still worse OS was observed in patients with curative resection for recurrent right-sided CC compared to those with resection for recurrent left-sided CC (5-year: 42.2 vs 71%; P = 0.03).

Conclusion

Surgical resection undoubtedly improved survival after recurrence, however, patients with surgical resection for recurrent right-sided CC tended to have a worse prognosis.

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Acknowledgements

We thank JAM Post Inc. (Renton, WA, USA) for proofreading our draft.

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Authors and Affiliations

  1. Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, 1-1, Kanokoden, Chikusa, Nagoya, Aichi, 464-8681, Japan

    Tairin Uchino, Akira Ouchi, Koji Komori, Takashi Kinoshita, Taihei Oshiro & Yasuhiro Shimizu

  2. Department of Gastroenterological Surgery, Aichi Medical University, 1-1, Yazakokarimata, Nagakute, Aichi, 480-1195, Japan

    Tairin Uchino & Tsuyoshi Sano

Authors
  1. Tairin Uchino
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  2. Akira Ouchi
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  3. Koji Komori
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  4. Takashi Kinoshita
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  5. Taihei Oshiro
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  6. Tsuyoshi Sano
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  7. Yasuhiro Shimizu
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Correspondence to Akira Ouchi.

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Uchino, T., Ouchi, A., Komori, K. et al. The prognostic relevance of primary tumor sidedness to surgical treatment for recurrent colon cancer. Surg Today 51, 94–100 (2021). https://doi.org/10.1007/s00595-020-02060-0

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  • DOI: https://doi.org/10.1007/s00595-020-02060-0

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