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Prevalence of and risk factors for thyroid carcinoma in patients with familial adenomatous polyposis: results of a multicenter study in Japan and a systematic review

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Abstract

Purpose

To investigate the recent Japanese prevalence of thyroid cancer and its characteristics in familial adenomatous polyposis (FAP) patients, through the development of surveillance programs.

Methods

The subjects of this study were 282 (93.1%) FAP patients for whom information on thyroid cancer was available, from among 303 patients registered in “the Retrospective Cohort Study of Familial Adenomatous Polyposis in Japan” database. We evaluated the prevalence and risk factors for thyroid cancer and integrated and/or compared our findings with those of previous reports, using a systematic review, including a meta-analysis.

Results

Thyroid cancer was diagnosed in 16 women (11.4%) and 2 men (1.4%), at 17–41 years and 39–57 years of age, respectively. The prevalence of thyroid cancer was 6.4%, with a female-to-male ratio of 8:1, which is comparable to reports from other countries. A young age of < 33 years at the FAP diagnosis and female gender were identified as independent risk factors for thyroid cancer.

Conclusions

FAP-associated thyroid cancer predominantly affects young women, both in Japan and other countries. Since FAP is generally diagnosed when patients are in their 20 s or older, regular screening for thyroid cancer is recommended for all FAP patients, but especially women, from their early 20 s.

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Acknowledgements

We appreciate the support with our statistical analyses, given by Minoru Hattori, Advanced Medical Skills Training Center, Hiroshima University, and we thank the Japanese Society for Cancer of Colon and Rectum (JSCCR) for their cooperation.

Author information

Author notes

  1. Takao Hinoi

    Present address: Department of Surgery, Institute for Clinical Research, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, 3-1, Aoyama-cho, Kure-shi, Hiroshima, 737-0023, Japan

Authors and Affiliations

  1. Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan

    Haruki Sada & Takao Hinoi

  2. Department of Surgery, National Defense Medical College, Saitama, Japan

    Hideki Ueno

  3. Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan

    Tatsuro Yamaguchi

  4. Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan

    Yasuhiro Inoue

  5. Gastroenterological Center, Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan

    Tsuyoshi Konishi

  6. Department of Surgery, Tokyo Metropolitan Hiroo Hospital, Tokyo, Japan

    Hirotoshi Kobayashi

  7. Division of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan

    Yukihide Kanemitsu

  8. Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan

    Fumio Ishida

  9. Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan

    Hideyuki Ishida

  10. Division of Lower GI Surgery, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan

    Naohiro Tomita & Nagahide Matsubara

  11. Tokyo Medical and Dental University, Tokyo, Japan

    Kenichi Sugihara

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  1. Haruki Sada
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Correspondence to Takao Hinoi.

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Sada, H., Hinoi, T., Ueno, H. et al. Prevalence of and risk factors for thyroid carcinoma in patients with familial adenomatous polyposis: results of a multicenter study in Japan and a systematic review. Surg Today 49, 72–81 (2019). https://doi.org/10.1007/s00595-018-1710-3

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  • DOI: https://doi.org/10.1007/s00595-018-1710-3

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