Surgery Today

, Volume 48, Issue 10, pp 952–962 | Cite as

The investigation of the survival time after recurrence in patients with pancreatic ductal adenocarcinoma for individualization of adjuvant chemotherapy

  • Daisaku Yamada
  • Hidetoshi Eguchi
  • Yoshifumi Iwagami
  • Tadafumi Asaoka
  • Takehiro Noda
  • Koichi Kawamoto
  • Kunihito Gotoh
  • Shogo Kobayashi
  • Masaki Mori
  • Yuichiro Doki
Original Article



Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease; however, the frequency of recurrence can be reduced if curative surgery following adjuvant chemotherapy is applied. At present, adjuvant chemotherapy is uniformly performed in all patients, as it is unclear which tumor types are controlled best or worst. We investigated patients with recurrence to establish the optimum treatment strategy.


Of 138 patients who underwent curative surgery for PDAC, 85 developed recurrence. Comprehensive clinicopathological factors were investigated for their association with the survival time after recurrence (SAR).


The median SAR was 12.6 months. Treatments for recurrence included best supportive care, GEM-based therapy and S-1. The performance status [hazard ratio (HR) 0.12, P < 0.001], histological invasion of lymph vessels (HR 0.27, P < 0.001), kind of treatment for recurrence (HR 5.0, P < 0.001) and initial recurrence site (HR 2.9, P < 0.001) were independent significant risk factors for the SAR. The initial recurrence sites were the liver (n = 21, median SAR 8.8 months), lung (n = 10, 14.9 months), peritoneum (n = 6, 1.7 months), lymph nodes (n = 6, 14.7 months), local site (n = 17, 13.9 months) and multiple sites (n = 25, 10.1 months). A shorter recurrence-free survival (< 1 year) and higher postoperative CA19-9 level were significantly associated with critical recurrence (peritoneal/liver).


Several risk factors for SAR were detected in this study. Further investigations are needed to individualize the adjuvant chemotherapy for each patient with PDAC.


Pancreatic ductal adenocarcinoma Recurrence Adjuvant chemotherapy 



We thank Dr. Paul Kretchmer and all of the other editors at San Francisco Edit for helping in editing the English language content of our paper.


We have nothing to disclose. This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors.

Supplementary material

595_2018_1674_MOESM1_ESM.docx (31 kb)
Supplementary material 1 (DOCX 30 KB)


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Daisaku Yamada
    • 1
  • Hidetoshi Eguchi
    • 1
  • Yoshifumi Iwagami
    • 1
  • Tadafumi Asaoka
    • 1
  • Takehiro Noda
    • 1
  • Koichi Kawamoto
    • 1
  • Kunihito Gotoh
    • 1
  • Shogo Kobayashi
    • 1
  • Masaki Mori
    • 1
  • Yuichiro Doki
    • 1
  1. 1.Department of Gastroenterological surgery, Graduate School of MedicineOsaka UniversitySuitaJapan

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