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Alcohol consumption and early-onset risk of colorectal cancer in Japanese patients with Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum

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Abstract

We conducted this study to establish whether drinking alcohol alters the risk of early-onset colorectal cancer (CRC) in Japanese patients with Lynch syndrome (LS). The subjects were 66 LS patients with pathogenic mutation of mismatch repair genes (MLH1, MSH2, and MSH6) from the nationwide Japanese retrospective multicenter study. Cox proportional hazards modeling was used to investigate the factors correlating with early-onset CRC diagnosis, using clinical data such as gender, tobacco use, alcohol consumption, body mass index, gene mutation (MLH1, MSH2 vs MSH6), and family cancer history. Alcohol was significantly correlated with an increased risk of early-onset CRC [HR 2.44, 95% CI 1.13–5.16 (p = 0.02)], but tobacco use was not [HR 0.8, 95%CI 0.38–1.62 (p = 0.53)]. These findings suggest that alcohol consumption is correlated with an earlier onset of CRC in Japanese patients with LS

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References

  1. Samowitz WS, Curtin K, Lin HH, Robertson MA, Schaffer D, Nichols M, et al. The colon cancer burden of genetically defined hereditary nonpolyposis colon cancer. Gastroenterology. 2001;121:830–8.

    Article  PubMed  CAS  Google Scholar 

  2. Mitchell RJ, Farrington SM, Dunlop MG, Campbell H. Mismatch repair genes hMLH1 and hMSH2 and colorectal cancer: a HuGE review. Am J Epidemiol. 2002;156:885–902.

    Article  PubMed  CAS  Google Scholar 

  3. Potter JD. At the interfaces of epidemiology, genetics and genomics. Nat Rev Genet. 2001;2:142–7.

    Article  PubMed  CAS  Google Scholar 

  4. Win AK, Dowty JG, English DR, Campbell PT, Young JP, Winship I, et al. Body mass index in early adulthood and colorectal cancer risk for carriers and non-carriers of germline mutations in DNA mismatch repair genes. Br J Cancer. 2011;105:162–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. Ait Ouakrim D, Dashti SG, Chau R, Buchanan DD, Clendenning M, Rosty C, et al. Aspirin, ibuprofen, and the risk of colorectal cancer in Lynch syndrome. J Natl Cancer Inst. 2015; 107.

  6. Wiseman M. The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Proc Nutr Soc. 2008; 67: 253–6.

    Article  PubMed  Google Scholar 

  7. Otani T, Iwasaki M, Yamamoto S, Sobue T, Hanaoka T, Inoue M, et al. Alcohol consumption, smoking, and subsequent risk of colorectal cancer in middle-aged and elderly Japanese men and women: Japan Public Health Center-based prospective study. Cancer Epidemiol Biomarkers Prev. 2003;12:1492 – 500.

    PubMed  CAS  Google Scholar 

  8. Pande M, Lynch PM, Hopper JL, Jenkins MA, Gallinger S, Haile RW, et al. Smoking and colorectal cancer in Lynch syndrome: results from the Colon Cancer Family Registry and the University of Texas M.D. Anderson Cancer Center. Clin Cancer Res. 2010;16:1331–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  9. Winkels RM, Botma A, Van Duijnhoven FJ, Nagengast FM, Kleibeuker JH, Vasen HF, et al. Smoking increases the risk for colorectal adenomas in patients with Lynch syndrome. Gastroenterology. 2012;142:241–7.

    Article  PubMed  Google Scholar 

  10. Tanakaya K, Furukawa Y, Nakamura Y, Hirata K, Tomita N, Tamura K, et al. Relationship between smoking and multiple colorectal cancers in patients with Japanese Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum. Jpn J Clin Oncol. 2015;45:307 – 10.

    Article  PubMed  Google Scholar 

  11. Yamaguchi T, Furukawa Y, Nakamura Y, Matsubara N, Ishikawa H, Arai M, et al. Comparison of clinical features between suspected familial colorectal cancer type X and Lynch syndrome in Japanese patients with colorectal cancer: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum. Jpn J Clin Oncol. 2015;45:153–9.

    Article  PubMed  Google Scholar 

  12. Tanakaya K, Yamaguchi T, Ishikawa H, Hinoi T, Furukawa Y, Hirata K, et al. Causes of cancer death among first-degree relatives in Japanese Families with Lynch syndrome. Anticancer Res. 2016;36:1985–9.

    PubMed  Google Scholar 

  13. Wimberly AL, Forsyth CB, Khan MW, Pemberton A, Khazaie K, Keshavarzian A. Ethanol-induced mast cell-mediated inflammation leads to increased susceptibility of intestinal tumorigenesis in the APC Delta468 min mouse model of colon cancer. Alcohol Clin Exp Res. 2013;37(Suppl 1):E199–E208.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  14. Roy HK, Gulizia JM, Karolski WJ, Ratashak A, Sorrell MF, Tuma D. Ethanol promotes intestinal tumorigenesis in the MIN mouse. Multiple intestinal neoplasia. Cancer Epidemiol Biomarkers Prev. 2002;11:1499–502.

    PubMed  CAS  Google Scholar 

  15. Hsing AW, McLaughlin JK, Chow WH, Schuman LM, Co Chien HT, Gridley G, et al. Risk factors for colorectal cancer in a prospective study among U.S. white men. Int J Cancer. 1998;77:549–53.

    Article  PubMed  CAS  Google Scholar 

  16. Flood A, Caprario L, Chaterjee N, Lacey JV Jr, Schairer C, Schatzkin A. Folate, methionine, alcohol, and colorectal cancer in a prospective study of women in the United States. Cancer Causes Control. 2002;13:551–61.

    Article  PubMed  Google Scholar 

  17. Glynn SA, Albanes D, Pietinen P, Brown CC, Rautalahti M, Tangrea JA, et al. Alcohol consumption and risk of colorectal cancer in a cohort of Finnish men. Cancer Causes Control. 1996;7:214–23.

    Article  PubMed  CAS  Google Scholar 

  18. Longnecker MP, Orza MJ, Adams ME, Vioque J, Chalmers TC. A meta-analysis of alcoholic beverage consumption in relation to risk of colorectal cancer. Cancer Causes Control. 1990;1:59–68.

    Article  PubMed  CAS  Google Scholar 

  19. Pedersen A, Johansen C, Gronbaek M. Relations between amount and type of alcohol and colon and rectal cancer in a Danish population based cohort study. Gut. 2003;52:861–7.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  20. Diergaarde B, Braam H, Vasen HF, Nagengast FM, van Muijen GN, Kok FJ, et al. Environmental factors and colorectal tumor risk in individuals with hereditary nonpolyposis colorectal cancer. Clin Gastroenterol Hepatol. 2007;5:736 – 42.

    Article  PubMed  Google Scholar 

  21. Watson P, Vasen HF, Mecklin JP, Bernstein I, Aarnio M, Jarvinen HJ, et al. The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome. Int J Cancer. 2008;123:444–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  22. Burn J, Gerdes AM, Macrae F, Mecklin JP, Moeslein G, Olschwang S, et al. Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet. 2011;378:2081–7.

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, 7348551, Hiroshima, Japan

    Masashi Miguchi & Takao Hinoi

  2. Department of Surgery, Iwakuni Clinical Center, Yamaguchi, Japan

    Kohji Tanakaya

  3. Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan

    Tatsuro Yamaguchi

  4. Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

    Yoichi Furukawa

  5. Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan

    Teruhiko Yoshida

  6. Major in Science, Graduate School of Science and Engineering Research, Kinki University, Higashiosaka, Japan

    Kazuo Tamura

  7. Oncogene Research Unit/Cancer Prevention Unit, Tochigi Cancer Center Research Institute, Utsunomiya, Japan

    Kokichi Sugano

  8. Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan

    Chikashi Ishioka

  9. Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan

    Nagahide Matsubara & Naohiro Tomita

  10. Clinical Genetic Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan

    Masami Arai

  11. Department of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Hideki Ishikawa

  12. Department of Surgery 1, University of Occupational and Environmental Health, Kitakyushu, Japan

    Keiji Hirata

  13. Department of Surgery, Toho University Ohashi Medical Center, Tokyo, Japan

    Yoshihisa Saida

  14. Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan

    Hideyuki Ishida

  15. Tokyo Medical and Dental University, Tokyo, Japan

    Kenichi Sugihara

Authors
  1. Masashi Miguchi
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  2. Takao Hinoi
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  3. Kohji Tanakaya
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  4. Tatsuro Yamaguchi
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  5. Yoichi Furukawa
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  6. Teruhiko Yoshida
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  7. Kazuo Tamura
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  8. Kokichi Sugano
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  9. Chikashi Ishioka
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  10. Nagahide Matsubara
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  11. Naohiro Tomita
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  12. Masami Arai
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  13. Hideki Ishikawa
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  14. Keiji Hirata
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  15. Yoshihisa Saida
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  16. Hideyuki Ishida
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  17. Kenichi Sugihara
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Corresponding author

Correspondence to Takao Hinoi.

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Miguchi, M., Hinoi, T., Tanakaya, K. et al. Alcohol consumption and early-onset risk of colorectal cancer in Japanese patients with Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum. Surg Today 48, 810–814 (2018). https://doi.org/10.1007/s00595-018-1654-7

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  • DOI: https://doi.org/10.1007/s00595-018-1654-7

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