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Surgery Today

, Volume 47, Issue 4, pp 416–424 | Cite as

Attempts to prevent postoperative pancreatic fistula after distal pancreatectomy

  • Yoshihiro Miyasaka
  • Yasuhisa Mori
  • Kohei Nakata
  • Takao Ohtsuka
  • Masafumi Nakamura
Review Article

Abstract

Postoperative pancreatic fistula (POPF) is the most frequent and serious complication after distal pancreatectomy (DP) and often leads to other postoperative complications. Numerous studies have been conducted to clarify the risk factors for POPF after DP, and to also determine effective prophylactic treatments. In this article, we review the current evidence on the risk factors for POPF after DP, and also provide new evidence to support the currently implemented prophylactic measures against POPF after DP. The patient-related and surgery-related risk factors and risk factors specific to staplers are discussed. Several studies have suggested that a thick pancreas is a risk factor for POPF using a stapler and that a higher stapler height or pancreatoenteric anastomosis might be useful for preventing POPF when transecting a thick pancreas. Various methods, such as stapler closure, procedures that may be performed in addition to stapler closure, pancreatoenteric anastomosis, pancreatic transection devices, laparoscopic surgery, pancreatic stenting, stump coverage, and somatostatin analogs, have been tested and in comparison with conventional procedures in case–control studies and randomized, controlled trials. Although some studies have shown the superiority of these methods to the conventional procedures, a consensus on precautionary measures that can be taken against POPF remains to be established. Further investigation is necessary to develop a reliable strategy for preventing POPF and to improve the outcomes of patients after DP.

Keywords

Distal pancreatectomy Postoperative pancreatic fistula Stapler Pancreatoenteric anastomosis 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare no conflicts of interest in association with this manuscript.

References

  1. 1.
    Witzel O. Aus der Klinik des Herrn Prof. Trendelenburg. Beitrage zur Chirurgie der Bauchorgane. Deutsche Zeitschrift fur. Chirurgie. 1886;24:326–54.Google Scholar
  2. 2.
    Fox AM, Pitzul K, Bhojani F, Kaplan M, Moulton CA, Wei AC, et al. Comparison of outcomes and costs between laparoscopic distal pancreatectomy and open resection at a single center. Surg Endosc. 2012;26:1220–30.CrossRefPubMedGoogle Scholar
  3. 3.
    Nakamura M, Wakabayashi G, Miyasaka Y, Tanaka M, Morikawa T, Unno M, et al. Multicenter comparative study of laparoscopic and open distal pancreatectomy using propensity score-matching. J Hepatobiliary Pancreat Sci. 2015;22:731–6.CrossRefPubMedGoogle Scholar
  4. 4.
    Ricci C, Casadei R, Buscemi S, Taffurelli G, D’Ambra M, Pacilio CA, et al. Laparoscopic distal pancreatectomy: what factors are related to the learning curve? Surg Today. 2015;45:50–6.CrossRefPubMedGoogle Scholar
  5. 5.
    Nathan H, Cameron JL, Goodwin CR, Seth AK, Edil BH, Wolfgang CL, et al. Risk factors for pancreatic leak after distal pancreatectomy. Ann Surg. 2009;250:277–81.CrossRefPubMedGoogle Scholar
  6. 6.
    Bassi C, Butturini G, Molinari E, Mascetta G, Salvia R, Falconi M, et al. Pancreatic fistula rate after pancreatic resection. The importance of definitions. Dig Surg. 2004;21:54–9.CrossRefPubMedGoogle Scholar
  7. 7.
    Bassi C, Dervenis C, Butturini G, Fingerhut A, Yeo C, Izbicki J, et al. Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery. 2005;138:8–13.CrossRefPubMedGoogle Scholar
  8. 8.
    Ferrone CR, Warshaw AL, Rattner DW, Berger D, Zheng H, Rawal B, et al. Pancreatic fistula rates after 462 distal pancreatectomies: staplers do not decrease fistula rates. J Gastrointest Surg. 2008;12:1691–7 (discussion 7–8).CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Eguchi H, Nagano H, Tanemura M, Takeda Y, Marubashi S, Kobayashi S, et al. A thick pancreas is a risk factor for pancreatic fistula after a distal pancreatectomy: selection of the closure technique according to the thickness. Dig Surg. 2011;28:50–6.CrossRefPubMedGoogle Scholar
  10. 10.
    Kleeff J, Diener MK, Z’Graggen K, Hinz U, Wagner M, Bachmann J, et al. Distal pancreatectomy: risk factors for surgical failure in 302 consecutive cases. Ann Surg. 2007;245:573–82.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Nakamura M, Shindo K, Ideno N, Ueda J, Takahata S, Nakashima H, et al. Prediction of pancreatic fistula by preoperatively assessable factors; retrospective review of unified operations by single surgeon. Hepatogastroenterology. 2014;61:834–7.PubMedGoogle Scholar
  12. 12.
    Yoshioka R, Saiura A, Koga R, Seki M, Kishi Y, Morimura R, et al. Risk factors for clinical pancreatic fistula after distal pancreatectomy: analysis of consecutive 100 patients. World J Surg. 2010;34:121–5.CrossRefPubMedGoogle Scholar
  13. 13.
    Hashimoto Y, Traverso LW. After distal pancreatectomy pancreatic leakage from the stump of the pancreas may be due to drain failure or pancreatic ductal back pressure. J Gastrointest Surg. 2012;16:993–1003.CrossRefPubMedGoogle Scholar
  14. 14.
    Seeliger H, Christians S, Angele MK, Kleespies A, Eichhorn ME, Ischenko I, et al. Risk factors for surgical complications in distal pancreatectomy. Am J Surg. 2010;200:311–7.CrossRefPubMedGoogle Scholar
  15. 15.
    Ridolfini MP, Alfieri S, Gourgiotis S, Di Miceli D, Rotondi F, Quero G, et al. Risk factors associated with pancreatic fistula after distal pancreatectomy, which technique of pancreatic stump closure is more beneficial? World J Gastroenterol. 2007;13:5096–100.CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Distler M, Kersting S, Ruckert F, Kross P, Saeger HD, Weitz J, et al. Chronic pancreatitis of the pancreatic remnant is an independent risk factor for pancreatic fistula after distal pancreatectomy. BMC Surg. 2014;14:54.CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Goh BK, Tan YM, Chung YF, Cheow PC, Ong HS, Chan WH, et al. Critical appraisal of 232 consecutive distal pancreatectomies with emphasis on risk factors, outcome, and management of the postoperative pancreatic fistula: a 21-year experience at a single institution. Arch Surg. 2008;143:956–65.CrossRefPubMedGoogle Scholar
  18. 18.
    Arima K, Hashimoto D, Okabe H, Inoue R, Kaida T, Higashi T, et al. Intraoperative blood loss is not a predictor of prognosis for pancreatic cancer. Surg Today. 2015;. doi: 10.1007/s0059501512388.Google Scholar
  19. 19.
    Bilimoria MM, Cormier JN, Mun Y, Lee JE, Evans DB, Pisters PW. Pancreatic leak after left pancreatectomy is reduced following main pancreatic duct ligation. Br J Surg. 2003;90:190–6.CrossRefPubMedGoogle Scholar
  20. 20.
    Sell NM, Pucci MJ, Gabale S, Leiby BE, Rosato EL, Winter JM, et al. The influence of transection site on the development of pancreatic fistula in patients undergoing distal pancreatectomy: a review of 294 consecutive cases. Surgery. 2015;157:1080–7.CrossRefPubMedGoogle Scholar
  21. 21.
    Frozanpor F, Albiin N, Linder S, Segersvard R, Lundell L, Arnelo U. Impact of pancreatic gland volume on fistula formation after pancreatic tail resection. JOP. 2010;11:439–43.PubMedGoogle Scholar
  22. 22.
    Arai T, Kobayashi A, Yokoyama T, Ohya A, Fujinaga Y, Shimizu A, et al. Signal intensity of the pancreas on magnetic resonance imaging: prediction of postoperative pancreatic fistula after a distal pancreatectomy using a triple-row stapler. Pancreatology. 2015;15:380–6.CrossRefPubMedGoogle Scholar
  23. 23.
    Kawabata Y, Nishi T, Tanaka T, Yano S, Tajima Y. Distal pancreatectomy utilizing a flexible stapler closure eliminates the risk of pancreas-related factors for postoperative pancreatic fistula. Eur Surg Res. 2013;50:71–9.CrossRefPubMedGoogle Scholar
  24. 24.
    Kawai M, Tani M, Okada K, Hirono S, Miyazawa M, Shimizu A, et al. Stump closure of a thick pancreas using stapler closure increases pancreatic fistula after distal pancreatectomy. Am J Surg. 2013;206:352–9.CrossRefPubMedGoogle Scholar
  25. 25.
    Okano K, Oshima M, Kakinoki K, Yamamoto N, Akamoto S, Yachida S, et al. Pancreatic thickness as a predictive factor for postoperative pancreatic fistula after distal pancreatectomy using an endopath stapler. Surg Today. 2013;43:141–7.CrossRefPubMedGoogle Scholar
  26. 26.
    Subhedar PD, Patel SH, Kneuertz PJ, Maithel SK, Staley CA, Sarmiento JM, et al. Risk factors for pancreatic fistula after stapled gland transection. Am Surg. 2011;77:965–70.PubMedGoogle Scholar
  27. 27.
    Sugimoto M, Gotohda N, Kato Y, Takahashi S, Kinoshita T, Shibasaki H, et al. Risk factor analysis and prevention of postoperative pancreatic fistula after distal pancreatectomy with stapler use. J Hepatobiliary Pancreat Sci. 2013;20:538–44.CrossRefPubMedGoogle Scholar
  28. 28.
    Sepesi B, Moalem J, Galka E, Salzman P, Schoeniger LO. The influence of staple size on fistula formation following distal pancreatectomy. J Gastrointest Surg. 2012;16:267–74.CrossRefPubMedGoogle Scholar
  29. 29.
    Kuroki T, Eguchi S. Laparoscopic distal pancreatosplenectomy for pancreatic ductal adenocarcinoma. Surg Today. 2015;45:808–12.CrossRefPubMedGoogle Scholar
  30. 30.
    Pachter HL, Pennington R, Chassin J, Spencer FC. Simplified distal pancreatectomy with the Auto Suture stapler: preliminary clinical observations. Surgery. 1979;85:166–70.PubMedGoogle Scholar
  31. 31.
    Bassi C, Butturini G, Falconi M, Salvia R, Sartori N, Caldiron E, et al. Prospective randomised pilot study of management of the pancreatic stump following distal resection. HPB (Oxford). 1999;1:203–7.Google Scholar
  32. 32.
    Ceppa EP, McCurdy RM, Becerra DC, Kilbane EM, Zyromski NJ, Nakeeb A, et al. Does pancreatic stump closure method influence distal pancreatectomy outcomes? J Gastrointest Surg. 2015;19:1449–56.CrossRefPubMedGoogle Scholar
  33. 33.
    Diener MK, Seiler CM, Rossion I, Kleeff J, Glanemann M, Butturini G, et al. Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial. Lancet. 2011;377:1514–22.CrossRefPubMedGoogle Scholar
  34. 34.
    Pannegeon V, Pessaux P, Sauvanet A, Vullierme MP, Kianmanesh R, Belghiti J. Pancreatic fistula after distal pancreatectomy: predictive risk factors and value of conservative treatment. Arch Surg. 2006;141:1071–6 (discussion 6).CrossRefPubMedGoogle Scholar
  35. 35.
    Knaebel HP, Diener MK, Wente MN, Buchler MW, Seiler CM. Systematic review and meta-analysis of technique for closure of the pancreatic remnant after distal pancreatectomy. Br J Surg. 2005;92:539–46.CrossRefPubMedGoogle Scholar
  36. 36.
    Zhang H, Zhu F, Shen M, Tian R, Shi CJ, Wang X, et al. Systematic review and meta-analysis comparing three techniques for pancreatic remnant closure following distal pancreatectomy. Br J Surg. 2015;102:4–15.CrossRefPubMedGoogle Scholar
  37. 37.
    Zhou W, Lv R, Wang X, Mou Y, Cai X, Herr I. Stapler vs suture closure of pancreatic remnant after distal pancreatectomy: a meta-analysis. Am J Surg. 2010;200:529–36.CrossRefPubMedGoogle Scholar
  38. 38.
    Ban D, Shimada K, Konishi M, Saiura A, Hashimoto M, Uesaka K. Stapler and nonstapler closure of the pancreatic remnant after distal pancreatectomy: multicenter retrospective analysis of 388 patients. World J Surg. 2012;36:1866–73.CrossRefPubMedGoogle Scholar
  39. 39.
    Nakamura M, Ueda J, Kohno H, Aly MY, Takahata S, Shimizu S, et al. Prolonged peri-firing compression with a linear stapler prevents pancreatic fistula in laparoscopic distal pancreatectomy. Surg Endosc. 2011;25:867–71.CrossRefPubMedGoogle Scholar
  40. 40.
    Ariyarathenam AV, Bunting D, Aroori S. Laparoscopic distal pancreatectomy using the modified prolonged prefiring compression technique reduces pancreatic fistula. J Laparoendosc Adv Surg Tech A. 2015;25:821–5.CrossRefPubMedGoogle Scholar
  41. 41.
    Balzano G, Zerbi A, Cristallo M, Di Carlo V. The unsolved problem of fistula after left pancreatectomy: the benefit of cautious drain management. J Gastrointest Surg. 2005;9:837–42.CrossRefPubMedGoogle Scholar
  42. 42.
    Finan KR, Cannon EE, Kim EJ, Wesley MM, Arnoletti PJ, Heslin MJ, et al. Laparoscopic and open distal pancreatectomy: a comparison of outcomes. Am Surg. 2009;75:671–9 (discussion 9–80).PubMedGoogle Scholar
  43. 43.
    Sheehan MK, Beck K, Creech S, Pickleman J, Aranha GV. Distal pancreatectomy: does the method of closure influence fistula formation? Am Surg. 2002;68:264–7 (discussion 7–8).PubMedGoogle Scholar
  44. 44.
    Hamilton NA, Porembka MR, Johnston FM, Gao F, Strasberg SM, Linehan DC, et al. Mesh reinforcement of pancreatic transection decreases incidence of pancreatic occlusion failure for left pancreatectomy: a single-blinded, randomized controlled trial. Ann Surg. 2012;255:1037–42.CrossRefPubMedPubMedCentralGoogle Scholar
  45. 45.
    Jimenez RE, Mavanur A, Macaulay WP. Staple line reinforcement reduces postoperative pancreatic stump leak after distal pancreatectomy. J Gastrointest Surg. 2007;11:345–9.CrossRefPubMedGoogle Scholar
  46. 46.
    Thaker RI, Matthews BD, Linehan DC, Strasberg SM, Eagon JC, Hawkins WG. Absorbable mesh reinforcement of a stapled pancreatic transection line reduces the leak rate with distal pancreatectomy. J Gastrointest Surg. 2007;11:59–65.CrossRefPubMedGoogle Scholar
  47. 47.
    Yamamoto M, Hayashi MS, Nguyen NT, Nguyen TD, McCloud S, Imagawa DK. Use of Seamguard to prevent pancreatic leak following distal pancreatectomy. Arch Surg. 2009;144:894–9.CrossRefPubMedGoogle Scholar
  48. 48.
    Guzman EA, Nelson RA, Kim J, Pigazzi A, Trisal V, Paz B, et al. Increased incidence of pancreatic fistulas after the introduction of a bioabsorbable staple line reinforcement in distal pancreatic resections. Am Surg. 2009;75:954–7.PubMedGoogle Scholar
  49. 49.
    Johnston FM, Cavataio A, Strasberg SM, Hamilton NA, Simon PO Jr, Trinkaus K, et al. The effect of mesh reinforcement of a stapled transection line on the rate of pancreatic occlusion failure after distal pancreatectomy: review of a single institution’s experience. HPB (Oxford). 2009;11:25–31.CrossRefPubMedPubMedCentralGoogle Scholar
  50. 50.
    Kawai M, Hirono S, Okada KI, Sho M, Nakajima Y, Eguchi H, et al. Randomized controlled trial of pancreaticojejunostomy versus stapler closure of the pancreatic stump during distal pancreatectomy to reduce pancreatic fistula. Ann Surg. 2015;. doi: 10.1097/SLA.0000000000001395.PubMedPubMedCentralGoogle Scholar
  51. 51.
    Okada K, Kawai M, Tani M, Hirono S, Miyazawa M, Shimizu A, et al. Isolated Roux-en-Y anastomosis of the pancreatic stump in a duct-to-mucosa fashion in patients with distal pancreatectomy with en-bloc celiac axis resection. J Hepatobiliary Pancreat Sci. 2014;21:193–8.CrossRefPubMedGoogle Scholar
  52. 52.
    Klein F, Glanemann M, Faber W, Gul S, Neuhaus P, Bahra M. Pancreatoenteral anastomosis or direct closure of the pancreatic remnant after a distal pancreatectomy: a single-centre experience. HPB (Oxford). 2012;14:798–804.CrossRefPubMedPubMedCentralGoogle Scholar
  53. 53.
    Wagner M, Gloor B, Ambuhl M, Worni M, Lutz JA, Angst E, et al. Roux-en-Y drainage of the pancreatic stump decreases pancreatic fistula after distal pancreatic resection. J Gastrointest Surg. 2007;11:303–8.CrossRefPubMedGoogle Scholar
  54. 54.
    Meniconi RL, Caronna R, Borreca D, Schiratti M, Chirletti P. Pancreato-jejunostomy versus hand-sewn closure of the pancreatic stump to prevent pancreatic fistula after distal pancreatectomy: a retrospective analysis. BMC Surg. 2013;13:23.CrossRefPubMedPubMedCentralGoogle Scholar
  55. 55.
    Yanagimoto H, Satoi S, Toyokawa H, Yamamoto T, Hirooka S, Yamao J, et al. Pancreaticogastrostomy following distal pancreatectomy prevents pancreatic fistula-related complications. J Hepatobiliary Pancreat Sci. 2014;21:473–8.CrossRefPubMedGoogle Scholar
  56. 56.
    Suzuki Y, Fujino Y, Tanioka Y, Hori Y, Ueda T, Takeyama Y, et al. Randomized clinical trial of ultrasonic dissector or conventional division in distal pancreatectomy for non-fibrotic pancreas. Br J Surg. 1999;86:608–11.CrossRefPubMedGoogle Scholar
  57. 57.
    Sugo H, Mikami Y, Matsumoto F, Tsumura H, Watanabe Y, Futagawa S. Comparison of ultrasonically activated scalpel versus conventional division for the pancreas in distal pancreatectomy. J Hepatobiliary Pancreat Surg. 2001;8:349–52.CrossRefPubMedGoogle Scholar
  58. 58.
    Kawai M, Tani M, Yamaue H. Transection using bipolar scissors reduces pancreatic fistula after distal pancreatectomy. J Hepatobiliary Pancreat Surg. 2008;15:366–72.CrossRefPubMedGoogle Scholar
  59. 59.
    Blansfield JA, Rapp MM, Chokshi RJ, Woll NL, Hunsinger MA, Sheldon DG, et al. Novel method of stump closure for distal pancreatectomy with a 75 % reduction in pancreatic fistula rate. J Gastrointest Surg. 2012;16:524–8.CrossRefPubMedGoogle Scholar
  60. 60.
    Hartwig W, Duckheim M, Strobel O, Dovzhanskiy D, Bergmann F, Hackert T, et al. LigaSure for pancreatic sealing during distal pancreatectomy. World J Surg. 2010;34:1066–70.CrossRefPubMedGoogle Scholar
  61. 61.
    Nagakawa Y, Tsuchida A, Saito H, Tohyama Y, Matsudo T, Kawakita H, et al. The VIO soft-coagulation system can prevent pancreatic fistula following pancreatectomy. J Hepatobiliary Pancreat Surg. 2008;15:359–65.CrossRefPubMedGoogle Scholar
  62. 62.
    Gagner M, Pomp A, Herrera MF. Early experience with laparoscopic resections of islet cell tumors. Surgery. 1996;120:1051–4.CrossRefPubMedGoogle Scholar
  63. 63.
    Cuschieri A, Jakimowicz JJ, van Spreeuwel J. Laparoscopic distal 70 % pancreatectomy and splenectomy for chronic pancreatitis. Ann Surg. 1996;223:280–5.CrossRefPubMedPubMedCentralGoogle Scholar
  64. 64.
    Butturini G, Partelli S, Crippa S, Malleo G, Rossini R, Casetti L, et al. Perioperative and long-term results after left pancreatectomy: a single-institution, non-randomized, comparative study between open and laparoscopic approach. Surg Endosc. 2011;25:2871–8.CrossRefPubMedGoogle Scholar
  65. 65.
    de Rooij T, Jilesen AP, Boerma D, Bonsing BA, Bosscha K, van Dam RM, et al. A nationwide comparison of laparoscopic and open distal pancreatectomy for benign and malignant disease. J Am Coll Surg. 2015;220(263–70):e1.Google Scholar
  66. 66.
    DiNorcia J, Schrope BA, Lee MK, Reavey PL, Rosen SJ, Lee JA, et al. Laparoscopic distal pancreatectomy offers shorter hospital stays with fewer complications. J Gastrointest Surg. 2010;14:1804–12.CrossRefPubMedPubMedCentralGoogle Scholar
  67. 67.
    Jayaraman S, Gonen M, Brennan MF, D’Angelica MI, DeMatteo RP, Fong Y, et al. Laparoscopic distal pancreatectomy: evolution of a technique at a single institution. J Am Coll Surg. 2010;211:503–9.CrossRefPubMedGoogle Scholar
  68. 68.
    Mehta SS, Doumane G, Mura T, Nocca D, Fabre JM. Laparoscopic versus open distal pancreatectomy: a single-institution case-control study. Surg Endosc. 2012;26:402–7.CrossRefPubMedGoogle Scholar
  69. 69.
    Ricci C, Casadei R, Taffurelli G, Bogoni S, D’Ambra M, Ingaldi C, et al. Laparoscopic distal pancreatectomy in benign or premalignant pancreatic lesions: is it really more cost-effective than open approach? J Gastrointest Surg. 2015;19:1415–24.CrossRefPubMedGoogle Scholar
  70. 70.
    Rutz DR, Squires MH, Maithel SK, Sarmiento JM, Etra JW, Perez SD, et al. Cost comparison analysis of open versus laparoscopic distal pancreatectomy. HPB (Oxford). 2014;16:907–14.CrossRefPubMedPubMedCentralGoogle Scholar
  71. 71.
    Stauffer JA, Rosales-Velderrain A, Goldberg RF, Bowers SP, Asbun HJ. Comparison of open with laparoscopic distal pancreatectomy: a single institution’s transition over a 7-year period. HPB (Oxford). 2013;15:149–55.CrossRefPubMedGoogle Scholar
  72. 72.
    Vijan SS, Ahmed KA, Harmsen WS, Que FG, Reid-Lombardo KM, Nagorney DM, et al. Laparoscopic vs open distal pancreatectomy: a single-institution comparative study. Arch Surg. 2010;145:616–21.CrossRefPubMedGoogle Scholar
  73. 73.
    Xourafas D, Tavakkoli A, Clancy TE, Ashley SW. Distal pancreatic resection for neuroendocrine tumors: is laparoscopic really better than open? J Gastrointest Surg. 2015;19:831–40.CrossRefPubMedPubMedCentralGoogle Scholar
  74. 74.
    Yan JF, Kuang TT, Ji DY, Xu XW, Wang DS, Zhang RC, et al. Laparoscopic versus open distal pancreatectomy for benign or premalignant pancreatic neoplasms: a two-center comparative study. J Zhejiang Univ Sci B. 2015;16:573–9.CrossRefPubMedPubMedCentralGoogle Scholar
  75. 75.
    Costamagna G, Mutignani M, Ingrosso M, Vamvakousis V, Alevras P, Manta R, et al. Endoscopic treatment of postsurgical external pancreatic fistulas. Endoscopy. 2001;33:317–22.CrossRefPubMedGoogle Scholar
  76. 76.
    Saeed ZA, Ramirez FC, Hepps KS. Endoscopic stent placement for internal and external pancreatic fistulas. Gastroenterology. 1993;105:1213–7.CrossRefPubMedGoogle Scholar
  77. 77.
    Wu X, Li M, Wu W, Mu J, Zhang L, Ding Q, et al. The role of prophylactic transpapillary pancreatic stenting in distal pancreatectomy: a meta-analysis. Front Med. 2013;7:499–505.CrossRefPubMedGoogle Scholar
  78. 78.
    Abe N, Sugiyama M, Suzuki Y, Yamaguchi T, Mori T, Atomi Y. Preoperative endoscopic pancreatic stenting: a novel prophylactic measure against pancreatic fistula after distal pancreatectomy. J Hepatobiliary Pancreat Surg. 2008;15:373–6.CrossRefPubMedGoogle Scholar
  79. 79.
    Fischer CP, Bass B, Fahy B, Aloia T. Transampullary pancreatic duct stenting decreases pancreatic fistula rate following left pancreatectomy. Hepatogastroenterology. 2008;55:244–8.PubMedGoogle Scholar
  80. 80.
    Oida T, Mimatsu K, Kanou H, Kawasaki A, Fukino N, Kida K, et al. A new surgical technique of transduodenal pancreatic juice drainage prevents pancreatic fistula following distal pancreatectomy. Hepatogastroenterology. 2011;58:1398–402.CrossRefPubMedGoogle Scholar
  81. 81.
    Rieder B, Krampulz D, Adolf J, Pfeiffer A. Endoscopic pancreatic sphincterotomy and stenting for preoperative prophylaxis of pancreatic fistula after distal pancreatectomy. Gastrointest Endosc. 2010;72:536–42.CrossRefPubMedGoogle Scholar
  82. 82.
    Frozanpor F, Lundell L, Segersvard R, Arnelo U. The effect of prophylactic transpapillary pancreatic stent insertion on clinically significant leak rate following distal pancreatectomy: results of a prospective controlled clinical trial. Ann Surg. 2012;255:1032–6.CrossRefPubMedGoogle Scholar
  83. 83.
    Suzuki Y, Kuroda Y, Morita A, Fujino Y, Tanioka Y, Kawamura T, et al. Fibrin glue sealing for the prevention of pancreatic fistulas following distal pancreatectomy. Arch Surg. 1995;130:952–5.CrossRefPubMedGoogle Scholar
  84. 84.
    Hassenpflug M, Hartwig W, Strobel O, Hinz U, Hackert T, Fritz S, et al. Decrease in clinically relevant pancreatic fistula by coverage of the pancreatic remnant after distal pancreatectomy. Surgery. 2012;152:S164–71.CrossRefPubMedGoogle Scholar
  85. 85.
    Carter TI, Fong ZV, Hyslop T, Lavu H, Tan WP, Hardacre J, et al. A dual-institution randomized controlled trial of remnant closure after distal pancreatectomy: does the addition of a falciform patch and fibrin glue improve outcomes? J Gastrointest Surg. 2013;17:102–9.CrossRefPubMedGoogle Scholar
  86. 86.
    Montorsi M, Zerbi A, Bassi C, Capussotti L, Coppola R, Sacchi M. Efficacy of an absorbable fibrin sealant patch (TachoSil) after distal pancreatectomy: a multicenter, randomized, controlled trial. Ann Surg. 2012;256:853–9 (discussion 9–60).CrossRefPubMedGoogle Scholar
  87. 87.
    Park JS, Lee DH, Jang JY, Han Y, Yoon DS, Kim JK, et al. Use of TachoSil patches to prevent pancreatic leaks after distal pancreatectomy: a prospective, multicenter, randomized controlled study. J Hepatobiliary Pancreat Sci. 2016;23:110–7.CrossRefPubMedGoogle Scholar
  88. 88.
    Sa Cunha A, Carrere N, Meunier B, Fabre JM, Sauvanet A, Pessaux P, et al. Stump closure reinforcement with absorbable fibrin collagen sealant sponge (TachoSil) does not prevent pancreatic fistula after distal pancreatectomy: the FIABLE multicenter controlled randomized study. Am J Surg. 2015;210:739–48.CrossRefPubMedGoogle Scholar
  89. 89.
    Gurusamy KS, Koti R, Fusai G, Davidson BR. Somatostatin analogues for pancreatic surgery. Cochrane Database Syst Rev. 2013;4:CD008370.Google Scholar
  90. 90.
    Allen PJ, Gonen M, Brennan MF, Bucknor AA, Robinson LM, Pappas MM, et al. Pasireotide for postoperative pancreatic fistula. N Engl J Med. 2014;370:2014–22.CrossRefPubMedGoogle Scholar
  91. 91.
    Sarr MG. The potent somatostatin analogue vapreotide does not decrease pancreas-specific complications after elective pancreatectomy: a prospective, multicenter, double-blinded, randomized, placebo-controlled trial. J Am Coll Surg. 2003;196:556–64 (discussion 64–5; author reply 65).CrossRefPubMedGoogle Scholar
  92. 92.
    Lorenz U, Maier M, Steger U, Topfer C, Thiede A, Timm S. Analysis of closure of the pancreatic remnant after distal pancreatic resection. HPB (Oxford). 2007;9:302–7.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Japan 2016

Authors and Affiliations

  • Yoshihiro Miyasaka
    • 1
  • Yasuhisa Mori
    • 1
  • Kohei Nakata
    • 1
  • Takao Ohtsuka
    • 1
  • Masafumi Nakamura
    • 1
  1. 1.Department of Surgery and Oncology, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan

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