Diminished heart rate variability in type 2 diabetes is exacerbated during exercise-heat stress

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We thank all the participants who volunteered for the present study and the members of the Human and Environmental Physiology Research Unit (HEPRU), especially Dr. M. Poirier.


This project was supported by the Canadian Institutes of Health Research (Grants# 286363 and 399434; funds held by GPK). SRN is supported by a Postdoctoral Fellowship from HEPRU. GPK is supported by a University of Ottawa Research Chair.

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SRN and GPK conceptualized and designed the research; MJM performed statistical analysis, prepared figures, and drafted manuscript; All authors interpreted results; all authors edited, revised, and approved the final version. GPK is the guarantor of this work and, as such, had full access to all the data and takes responsibility for the integrity of the data and the accuracy of the data analysis. Data are available on request from the corresponding author.

Corresponding author

Correspondence to Glen P. Kenny.

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Conflict of interest

AJ.E. Seely is Founder and Board Chair of Therapeutic Monitoring Systems (TMS); TMS is developing and commercializing waveform-based variability-derived clinical decision support tools in order to improve care for patients at risk of or with existing critical illness. A.J.E. Seely and C.L. Herry are co-inventors on patents related to physiological waveform assessment and variability analysis. Otherwise, there are no conflicts of interest to declare, financial or otherwise.

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The study was approved by the University of Ottawa Research Ethics Board and conforms to the principles outlined in the Declaration of Helsinki.

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All participants provided written informed consent prior to their inclusion in the study.

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Macartney, M.J., Notley, S.R., Herry, C.L. et al. Diminished heart rate variability in type 2 diabetes is exacerbated during exercise-heat stress. Acta Diabetol 57, 899–901 (2020). https://doi.org/10.1007/s00592-020-01482-z

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