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Association between circulating visfatin and gestational diabetes mellitus: a systematic review and meta-analysis

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Abstract

Aims

Gestational diabetes mellitus (GDM) is a medical complication of any degree of glucose intolerance with onset or first recognition during pregnancy. Although visfatin is commonly considered to be related to GDM, studies revealed inconsistent results. This study aimed to clarify the relationship between visfatin and GDM.

Methods

The protocol for this study was registered in PROSPERO (No. CRD42018086204) in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). PubMed and Embase databases were used to search for relevant studies published up to September 30, 2017. The difference of visfatin levels between women with GDM and the controls was measured by standardised mean difference (SMD) and 95% confidence interval (CI).

Results

Twenty-six studies that were published in 24 articles met the inclusion criteria, in which 2305 participants (1033 with GDM, mean age 31.39 years and 1272 controls, and mean age 29.99 years) were included. The quantitative meta-analysis revealed no significant difference in circulating visfatin levels between women with GDM and the controls (SMD = 0.249, 95% CI = − 0.079 to 0.576, P = 0.137). Subgroup analyses were performed referring to body mass index (BMI) where inconsistent results have been observed between cases and controls groups. For the ten studies, in which the level of BMI in women with GDM was higher than that in the control group, the pooled result showed that circulating visfatin was significantly higher among women with GDM than the controls (SMD = 0.367, 95% CI = 0.06 to 0.728, P = 0.046). Of other 16 studies BMI-matched, the pooled SMD illustrated no difference of visfatin.

Conclusions

Our study elucidates that visfatin is not independently associated with GDM. Visfatin is linked to GDM through maternal overweight/obesity, which is one of the major factors leading to the development of GDM.

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Acknowledgements

We would like to thank Wei Wang, Edith Cowan University School of Medical and Health Sciences, for his help with conducting a scoping review for this study.

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Author notes

  1. Wangxin Zhang, Dan Zhao, and Zixiu Meng have contributed equally to this work.

Authors and Affiliations

  1. School of Basic Medical Science, Taishan Medical University, 2 Yingsheng East Road, Taian, 271000, People’s Republic of China

    Wangxin Zhang, Dan Zhao, Aishe Dun & Xu Jin

  2. Affiliated Hospital, Taishan Medical University, Taian, 271000, People’s Republic of China

    Wangxin Zhang, Dan Zhao, Huachen Wang & Kunsheng Zhao

  3. School of Public Health, Taishan Medical University, 2 Yingsheng East Road, Taian, 271000, People’s Republic of China

    Zixiu Meng, Xia Feng, Yuejin Li & Haifeng Hou

  4. School of Medical and Health Sciences, Edith Cowan University, Perth, 6027, Australia

    Haifeng Hou

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  1. Wangxin Zhang
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Contributions

HH, AD, and XJ designed the study. WZ, DZ, ZM HW, KZ, XF, and YL conducted the literature search, performed data extraction, and assessed study quality. HH and XJ conducted the statistical analyses. HH and AD wrote the manuscript. All authors interpreted data and revised the manuscript for important intellectual content. HH conceived of the study idea, supervised the study, and is the guarantor.

Corresponding authors

Correspondence to Aishe Dun, Xu Jin or Haifeng Hou.

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This study used published, aggregate data and did not involve human participants or animals. Consequently, research ethics board review was not required.

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Zhang, W., Zhao, D., Meng, Z. et al. Association between circulating visfatin and gestational diabetes mellitus: a systematic review and meta-analysis. Acta Diabetol 55, 1113–1120 (2018). https://doi.org/10.1007/s00592-018-1188-x

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