Acta Diabetologica

, Volume 55, Issue 6, pp 637–639 | Cite as

Switching from Glargine to Degludec is not associated with an overt change in glucose control in a cohort of patients with type 1 diabetes: a CGM analysis

  • Laura Affinito Bonabello
  • Davide Maggi
  • Samuele Fiorini
  • Veronica Tozzo
  • Renzo Cordera
Short Communication


After DCCT, intensive multiple daily insulin injections protocol became the standard therapy for patients with T1DM intended to maintain a lower HbA1c without hypoglycemia and thus to decrease the risk of microvascular complications. Design and production of new basal insulin analogs with lower risk of hypoglycemia was the next challenge. The switch from NPH to the basal insulin analog Glargine represented a major clinical advantage allowing to obtain a better and safer glucose control. Degludec is a new basal insulin analog with longer half-life and lower variability than Glargine [1]. Despite these differences, clinical trials comparing Glargine and Degludec in patients with T1DM and T2DM have failed to show a clear clinical advantage of Degludec in both efficacy and safety. A statistically significant lower number of hypoglycemic events, associated with Degludec versus Glargine, have been shown only in patients at high risk of hypoglycemia and intensively treated...


Degludec Glargine Continuous glucose monitoring Hypoglycemia 



Continuous glucose monitoring


Neutral protamine hagedorn


Type 1 diabetes mellitus


Type 2 diabetes mellitus


Area under curve


Continuous overlapping net glycemic action


Blood glucose rate


Low Blood Glucose Index


High Blood Glucose Index


Mean amplitude glycemic excursion


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Human and animal rights

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the 1975 Declaration of Helsinki, as revised in 2008.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Internal Medicine (DIMI)University of Genova and Ospedale Policlinico San MartinoGenoaItaly
  2. 2.Department of Informatics, Bioengineering, Robotics and Systems EngineeringUniversity of GenovaGenoaItaly

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