The 1-h post-load plasma glucose as a novel biomarker for diagnosing dysglycemia
- 207 Downloads
Identifying the earliest moment for intervention to avert progression to prediabetes and diabetes in high-risk individuals is a substantial challenge. As β-cell function is already compromised in prediabetes, attention should therefore be focused on identifying high-risk individuals earlier in the so-called pre-prediabetes stage. Biomarkers to monitor progression and identify the time point at which β-cell dysfunction occurs are therefore critically needed. Large-scale population studies have consistently shown that the 1-h plasma glucose (1-h PG) ≥ 155 mg/dl (8.6 mmol/l) during the oral glucose tolerance test detected incident type 2 diabetes and associated complications earlier than fasting plasma glucose or 2-h plasma glucose levels. An elevated 1-h PG level appears to be a better alternative to HbA1c [5.7–6.4% (37–47 mmol/mol)] or traditional glucose criteria for identifying high-risk individuals at a stage when ß-cell function is substantially more intact than in prediabetes. Diagnosing high-risk individuals earlier proffers the opportunity for potentially reducing progression to diabetes, development of microvascular complications and mortality, thereby advancing benefit beyond that which has been demonstrated in global diabetes prevention programs.
KeywordsDysglycemia Prediabetes Diabetes Oral glucose tolerance test
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Human and animal rights
This article does not contain any studies with human subjects performed by any of the authors.
Informed consent not applicable.
- 1.IDF Atlas-8th edition. http://www.diabetesatlas.org/key-messages.html
- 3.Herman WH, Ye W, Griffin SJ et al (2015) Early detection and treatment of type 2 diabetes reduce cardiovascular morbidity and mortality: a simulation of the results of the Anglo-Danish-Dutch study of intensive treatment in people with screen-detected diabetes in primary care (ADDITION-Europe). Diabetes Care 38:1449–1455CrossRefPubMedPubMedCentralGoogle Scholar
- 10.World Health Organization (2011) Use of glycated haemoglobin (HbA1c) in diagnosis of diabetes mellitus: abbreviated report of a WHO consultationGoogle Scholar
- 38.Bergman M, Chetrit A, Roth J, Jagannathan R, Sevick M, Dankner R (2016) One-hour post-load plasma glucose level during the OGTT predicts dysglycemia: observations from the 24 year follow-up of the Israel study of glucose intolerance, obesity and hypertension. Diabetes Res Clin Pract 120:221–228CrossRefPubMedGoogle Scholar
- 44.Manco M, Panunzi S, Macfarlane DP et al (2010) One-hour plasma glucose identifies insulin resistance and beta-cell dysfunction in individuals with normal glucose tolerance: cross-sectional data from the Relationship between insulin sensitivity and cardiovascular risk (RISC) study. Diabetes Care 33(9):2090–2097CrossRefPubMedPubMedCentralGoogle Scholar