Tuberculosis is a contagious disease caused by the bacteria, Mycobacterium Tuberculosis. Early detection of TB is vital to increase the chances of cure. In this paper, a MEMS cantilever based biosensor is designed and analyzed for the detection of TB antigen. The surface of the cantilever is coated with the TB antibody (ESAT-6). Since antibodies are disease specific, the presence of TB antigen in given patient sample is identified through the deflection of the cantilever beam. The analysis of the structure was performed by varying the length and width of the cantilever, material of the cantilever and shapes of the cantilever in order to obtain the maximum amount of deflection and sensitivity. The various cantilever types were simulated and the results were used to analyze the performance based on material and design. Stress concentrating region (SCR) designs have been included in the simulations so as to analyze the cantilever performances with these additional features. Also, in this work, the materials analyzed were aluminium, gold, platinum, polyimide and polysilicon. This method of detection was found to be simpler, less time consuming and more cost effective as compared to traditional TB detection methods like ELISA and IGRAs.
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Lakshmi, S., Almeida, A., Bagchi, A. et al. Detection of tuberculosis using MEMS. Microsyst Technol (2020). https://doi.org/10.1007/s00542-020-04918-2