Puncture performance of sharpen microneedles by using inclined contact UV lithography

Technical Paper
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Abstract

Microneedles is one of important future dispensing device for vaccination and diabetes. Solid microneedles is of wide application as it have also been designed to be coated with a drug for releasing into the skin by dissolution. Hard biodegradable polylactic acid (PLA) microneedles is suitable for solid microneedles because PLA provides safety in case microneedles accidentally break in the skin. The puncture performance of more sharpen microneedles have been demonstrated in this study. To make small tip radius and sharp tip angle to penetrate the skin from the viewpoints of ease of needling is key point on design of master mold. SU-8 mold manufactured by inclined contact UV lithography have been used for fabricating microneedles. To make designed small tip and shape tip angle on master mold, liquid impregnation method was introduced. Exposure value and developing time were optimized. Microneedles patch was replicated by molding PLA from dimethylpolysiloxane mold. The tip radius of pyramid microneedle was 3 μm and the tip angle of sold polymer microneedle was 18°, and these data were smallest tip radius and angle that have seen in all references. On imprint lithography process, thermoforming process was performed in the vacuum temperature chamber. As duration under decompressing in the vacuum temperature chamber was longer, the defects ratio of PLA microneedles became smaller. Microneedles patch was punctured into a mouse and human skins in high probability that is more than 80% after pressing the patch into the skin.

Notes

Acknowledgements

The authors thank Mr. Uemura and Inoguchi of Toppan Technical research institute for partly experimental assistant and support.

References

  1. Aravamudhan S, Kumar A, Mohapatra S, Bhansali S (2007) Sensitive estimation of total cholesterol in blood using Au nanowires based micro-fluidic platform. Biosens Bioelectron 22:2289–2294.  https://doi.org/10.1016/j.bios.2006.11.027 CrossRefGoogle Scholar
  2. Bariya SH, Gohel MC, Mehta TA, Sharma OP (2011) Microneedles: an emerging transdermal drug delivery system. J Pharm Pharmacol 64:11–29.  https://doi.org/10.1111/j.2042-7158.2011.01369.x CrossRefGoogle Scholar
  3. Beuret C, Racine GA, Gobet J, Luthier R, de Rooij NF (1994) Microfabrication of 3D multidirectional inclined structures by UV lithography and electroplating. In: Proceedings of IEEE international conference on MEMS (MEMS ‘94), pp 81–85Google Scholar
  4. Byeon KJ, Lee H (2012) Recent progress in direct patterning technologies based on nano-imprint lithography. Eur Phys J Appl Phys 59:10001.  https://doi.org/10.1051/epjap/2012120166 CrossRefGoogle Scholar
  5. Chou SY, Krauss PR, Renstrom PJ (1995) Imprint of sub-25 nm via and trenches in polymers. Appl Phys Lett 67:3114–3116.  https://doi.org/10.1063/1.114851 CrossRefGoogle Scholar
  6. Cui Z, Jenkins DWK, Schneider A, McBride G (2001) Profile control of SU-8 photoresist using different radiation sources. Proc SPIE 4407:119–125.  https://doi.org/10.1117/12.425291 CrossRefGoogle Scholar
  7. Davis SP, Landis BJ, Adams ZH, Allen MG, Prausnitz MR (2004) Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force. J Biomech 37:1155–1163.  https://doi.org/10.1016/j.jbiomech.2003.12.010 CrossRefGoogle Scholar
  8. Gill HS, Prausnitz MR (2007) Coated microneedles for transdermal delivery. J Control Release 117(2):227–237.  https://doi.org/10.1016/j.jconrel.2006.10.017 CrossRefGoogle Scholar
  9. Gill HS, Denson DD, Burris BA, Prausnitz MR (2008) Effect of microneedle design on pain in human subjects. Clin J Pain 24(7):585–594.  https://doi.org/10.1097/AJP.0b013e31816778f9 CrossRefGoogle Scholar
  10. Haisma J, Verheijen M, Heuvel K, Berg J (1996) Mold-assisted nanolithography: a process for reliable pattern replication. J Vac Sci Technol B 14:4124–4128.  https://doi.org/10.1116/1.588604 CrossRefGoogle Scholar
  11. Henry S, McAllister DV, Allen MG, Prausnitz MR (1998) Microfabricated microneedles: a novel approach to transdermal drug delivery. J Pharm Sci 87(8):922–925.  https://doi.org/10.1021/js980042+ CrossRefGoogle Scholar
  12. Hirai Y, Fujiwara M, Okuno T, Tanaka Y, Endo M, Irie S, Nakagawa K, Sasago M (2001) Study of the resist deformation in nanoimprint lithography. J Vac Sci Technol B 19:2811.  https://doi.org/10.1116/1.1415510 CrossRefGoogle Scholar
  13. Hoff JD, Cheng LJ, Meyhöfer E, Guo LJ, Hunt AJ (2004) Nanoscale protein patterning by imprint lithography. Nano Lett 4:853–857.  https://doi.org/10.1021/nl049758x CrossRefGoogle Scholar
  14. Hong CC, Choi JW, Chong HA (2002) Disposable air-bursting detonators as an alternative on-chip power source. In: Proceedings of IEEE fifth international conference on MEMS (MEMS ‘02), pp 230–234Google Scholar
  15. Hua F, Sun Y, Gaur A, Meitl MA, Bilhaut L, Rotkina L, Wang J, Geil P, Shim M, Rogers JA (2004) Polymer imprint lithography with molecular-scale resolution. Nano Lett 4:2467–2471.  https://doi.org/10.1021/nl048355u CrossRefGoogle Scholar
  16. Inerowicz HD, Howell S, Regnier FE, Reifenberger R (2002) Multiprotein immunoassay arrays fabricated by microcontact printing. Langmuir 18:5263–5268.  https://doi.org/10.1021/la0157216 CrossRefGoogle Scholar
  17. Jiang G, Baig S, Wang MR (2012) Prism-assisted inclined UV lithography for 3D microstructure fabrication. J Micromech Microeng 22:085022.  https://doi.org/10.1088/0960-1317/22/8/085022 CrossRefGoogle Scholar
  18. Kim MY, Jung B, Park J-H (2012) Hydrogel swelling as a trigger to release biodegradable polymer microneedles in skin. Biomaterials 33:668–678.  https://doi.org/10.1016/j.biomaterials.2011.09.074 CrossRefGoogle Scholar
  19. Koo N, Bender M, Plachetka U, Fuchs A, Wahlbrink T, Bolten J, Kurz H (2007) Improved mold fabrication for the definition of high quality nanopatterns by Soft UV-Nanoimprint lithography using diluted PDMS material. Microelectron Eng 84:904–908.  https://doi.org/10.1016/j.mee.2007.01.017 CrossRefGoogle Scholar
  20. Lee H, Jung G-Y (2004) UV curing nanoimprint lithography for uniform layers and minimized residual layers. Jpn J Appl Phys 43:8369–8373.  https://doi.org/10.1143/JJAP.43.8369 CrossRefGoogle Scholar
  21. Lee JW, Park JH, Prausnitz MR (2008) Dissolving microneedles for transdermal drug delivery. Biomaterials 29(13):2113–2124.  https://doi.org/10.1016/j.biomaterials.2007.12.048 CrossRefGoogle Scholar
  22. Lee JW, Choi S-O, Felner EI, Prausnitz MR (2011) Dissolving microneedle patch for transdermal delivery of human growth hormone. Small 7(4):531–539.  https://doi.org/10.1002/smll.201001091 CrossRefGoogle Scholar
  23. Lorenz H, Despont M, Fahrmi N, LaBianca N, Renaud P, Vettiger P (1997) SU-8: a low-cost negative resist for MEMS. J Micromech Microeng 7:121–124.  https://doi.org/10.1088/0960-1317/7/3/010 CrossRefGoogle Scholar
  24. Moony M (1940) A theory of large elastic deformation. J Appl Phys 11:582–592.  https://doi.org/10.1063/1.1712836 CrossRefGoogle Scholar
  25. Norman JJ, Choi S-O, Tong NT, Aiyar AR, Patel SR, Prausnitz MR, Allen MG (2013) Hollow microneedles for intradermal injection fabricated by sacrificial micromolding and selective electrodeposition. Biomed Microdevices 15(2):203–210.  https://doi.org/10.1007/s10544-012-9717-9 CrossRefGoogle Scholar
  26. Park JH, Choi S-O, Seo S, Choy YB, Prausnitz MR (2010) A microneedle roller for transdermal drug delivery. Eur J Pharm Biopharm 76:282–289.  https://doi.org/10.1016/j.ejpb.2010.07.001 CrossRefGoogle Scholar
  27. Roch I, Bidaud P, Collard D, Buchaillot L (2003) Fabrication and characterization of an SU-8 gripper actuated by a shape memory alloy thin film. J Micromech Microeng 13:330–336.  https://doi.org/10.1088/0960-1317/13/2/323 CrossRefGoogle Scholar
  28. Stephen YC, Peter RK, Preston JR (1995) Imprint of sub-25 nm vias and trenches in polymers. Appl Phys Lett 67:3114–3116.  https://doi.org/10.1063/1.114851 CrossRefGoogle Scholar
  29. Sullivan SP, Koutsonanos DG, Martin M der P, Lee J-W, Zarnitsyn V, Murthy N, Compans RW, Skountzou I, Prausnitz MR (2010) Dissolving polymer microneedle patches for influenza vaccination. Nat Med 16(8):915–920.  https://doi.org/10.1038/nm.2182 CrossRefGoogle Scholar
  30. Tomono T (2009) Method of fabricating master plate, method of fabricating microneedle patch and apparatus exposure apparatus, US patent 8,062,835Google Scholar
  31. Vecchione R, Coppola S, Esposito E, Casale C, Vespini V, Grilli S, Ferraro P, Netti PA (2014) Electro-drawn drug-loaded biodegradable polymer microneedles as a viable route to hypodermic injection. Adv Funct Mater 24:3515–3523.  https://doi.org/10.1002/adfm.201303679 CrossRefGoogle Scholar
  32. Yoon YK, Park JH, Lee JW, Prausnitz MR, Allen MG (2011) A thermal microjet system with tapered micronozzles fabricated by inclined UV lithography for transdermal drug delivery. J Micromech Microeng 21:025014.  https://doi.org/10.1088/0960-1317/21/2/025014 CrossRefGoogle Scholar
  33. Yoshimura C, Ishikawa H, Furuta S, Aoki H, Sugiyama S (2004) Development, strength and functional evaluation of plastic microneedle array fabricated by injection molding. IEEJ Trans SM 124(10):387–392.  https://doi.org/10.1541/ieejsmas.124.387 CrossRefGoogle Scholar
  34. Zahn JD, Talbot NH, Liepmann D, Pisano AP (2000) Microfabricated polysilicon microneedles for minimally invasive biomedical devices. Biomed Microdevice 2(4):295–303.  https://doi.org/10.1023/A:1009907306184 CrossRefGoogle Scholar
  35. Zhu Z, Zhou ZF, Huang Q-A, Li WH (2008) Modeling, simulation and experimental verification of inclined UV lithography for SU-8 negative thick photoresists. J Micromech Microeng 18:125017.  https://doi.org/10.1088/0960-1317/18/12/125017 CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.ICT Development Technology CenterToppan Printing Co., Ltd.TokyoJapan

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