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Micro and nanostructure based electrochemical sensor platform for glutamate detection

  • Mamun Jamal
  • Sumon Chakrabarty
  • Mohammad A. Yousuf
  • Ajit Khosla
  • Kafil M. Razeeb
Technical Paper
  • 142 Downloads

Abstract

l-Glutamate is one of the 20 standard amino acids used by all organisms. Due to the important role in clinical applications and in food processing industries, detection of this amino acid in food as well as in human serum is crucial. Number of research on monitoring glutamate has increased significantly over the last decade, so has the demand for this sensors increased with the requirement of improved performance. The key factors along with the selectivity are the strategy on electrode fabrication and designing high performance sensors with appropriate characteristics such as sensitivity, response time, stability, biocompatibility and reproducibility. Thereby, the application of micro and nanostructured sensor platform is becoming more popular due to its potential of enhancing these critical characteristics. This review focuses on the evolution of glutamate sensors from first to new generation based on micro and nanostructured electrode platforms as well as their performance characteristics. A brief comparison of various sensor generations, along with enzyme immobilization strategies are described in tabular form and then described in detail throughout the review.

Notes

Acknowledgements

Authors acknowledge financial support from the Ministry of Science and Technology, Bangladesh funded project “FACSens” under the special allocation to Science and Technology Activity (2015/16) programme; and Science Foundation Ireland funded project “SweatSens” under the Grant agreement no. 14/TIDA/2455.

References

  1. Alvarez-Crespo SL, Lobo-Castañón MJ, Miranda-Ordieres AJ, Tuñón-Blanco P (1997) Amperometric glutamate biosensor based on poly(o-phenylenediamine) film electro-generated onto modified carbon paste electrodes. Biosens Bioelectron 12:739–747CrossRefGoogle Scholar
  2. Batra B, Pundir CS (2013) An amperometric glutamate biosensor based on immobilization of glutamate oxidase onto carboxylated multiwalled carbon nanotubes/gold nanoparticles/chitosan composite film modified Au electrode. Biosens Bioelectron 47:496–501CrossRefGoogle Scholar
  3. Batra B, Kumari S, Pundir CS (2014) Construction of glutamate biosensor based on covalent immobilization of glutamate oxidase on polypyrrole nanoparticles/polyaniline modified gold electrode. Technol 57:69–77Google Scholar
  4. Bohmer E, Muller A, Passarge M, Liebs P, Honeck H, Muller H (1989) A novel l-glutamate oxidase from Streptomyces endus—purification and properties. Eur J Biochem 182:327–332CrossRefGoogle Scholar
  5. Borland LM, Shi G, Yang H, Michael AC (2005) Voltammetric study of extracellular dopamine near microdialysis probes acutely implanted in the striatum of the anesthetized rat. J Neurosci Meth 146:149–158CrossRefGoogle Scholar
  6. Burmeister JJ, Gerhardt GA (2001) Self-referencing ceramic-based multisite microelectrodes for the detection and elimination of interferences from the measurement of l-glutamate and other analytes. Anal Chem 73:1037–1042CrossRefGoogle Scholar
  7. Butterfield DA, Pocernich CB (2003) The glutamatergic system and Alzheimer’s disease: therapeutic implications. CNS Drugs 17:641–652CrossRefGoogle Scholar
  8. Cairns BE, Dong X, Mann MK, Svensson P, Sessle BJ, Nielsen LA, McErlane K (2007) Systemic administration of monosodium glutamate elevates intramuscular glutamate levels and sensitizes rat masseter muscle afferent fibers. Pain 132:33–41CrossRefGoogle Scholar
  9. Chapman J, Zhou M (1999) Microplate-based fluorometric methods for the enzymatic determination of l-glutamate: application in measuring l-glutamate in food samples. Anal Chim Acta 402:47–50CrossRefGoogle Scholar
  10. Chaubey A, Malhotra BD (2002) Mediated biosensors. Biosens Bioelectron 17:441–456CrossRefGoogle Scholar
  11. Chen BT, Avshalumov MV, Rice MJ (2002) Modulation of somatodendritic dopamine release by endogenous H2O2: susceptibility in substantia nigra but resistance in VTA. Neurophysiol 87:1155–1158CrossRefGoogle Scholar
  12. Claussen JC, Artiles MS, McLamore ES (2011) Electrochemical glutamate biosensing with nanocube and nanosphere augmented single-walled carbon nanotube networks: a comparative study. J Mater Chem 21:11224–11231CrossRefGoogle Scholar
  13. Cooper JM, Foreman PL, Glidle A, Ling TW, Pritchard DJ (1995) Glutamate oxidase enzyme electrodes: microsensors for neurotransmitter determination using electrochemically polymerized permselective films. J Electroanal Chem 388:143–149CrossRefGoogle Scholar
  14. Cosnier S, Innocent C, Allien L, Poitry S, Tsacopoulos M (1997) An electrochemical method for making enzyme microsensors, application to the detection of dopamine and glutamate. Anal Chem 69:968–971CrossRefGoogle Scholar
  15. Day BK, Pomerleau F, Burmeister JJ, Huettl P, Gerhardt GA (2006) Microelectrode array studies of basal and potassium-evoked release of l-glutamate in the anesthetized rat brain. J Neurochem 96:1626–1635CrossRefGoogle Scholar
  16. Fan Z, Harrison DJ (1992) Permeability of glucose and other neutral species through recast perfluoro-sulfonated ionomer films. Anal Chem 64:1304–1311CrossRefGoogle Scholar
  17. Filer LJ, Stegink LD (1994) A report of the proceedings of an MSG workshop held August 1991. Food Sci Nutr 34:159–174Google Scholar
  18. Fink SL, Cookson BT (2005) Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect Immun 73:1907–1916CrossRefGoogle Scholar
  19. Ford R, Quinn SJ, O’Neill RD (2016) Characterization of biosensors based on recombinant glutamate oxidase: comparison of crosslinking agents in terms of enzyme loading and efficiency parameters. Sensors 16:1565–1582CrossRefGoogle Scholar
  20. Gerhardt GA, Oke AF, Nagy G, Moghaddam B, Adams RN (1984) Nafion-coated electrodes with high selectivity for CNS electrochemistry. Brain Res 290:390–395CrossRefGoogle Scholar
  21. Gholizadeh A, Shahrokhian S, Zad AI, Mohajerzadeh S, Vosoughi M, Darbari S, Koohsorkhi J, Mehran M (2012) Fabrication of sensitive glutamate biosensor based on vertically aligned CNT nanoelectrode array and investigating the effect of CNTs density on the electrode performance. Anal Chem 84:5932–5938CrossRefGoogle Scholar
  22. Hamdi N, Wang J, Walker E (2006) An electroenzymatic l-glutamate microbiosensor selective against dopamine. J Electroanal Chem 591:33–40CrossRefGoogle Scholar
  23. Hascup KN, Hascup ER, Pomerleau F, Huettle P, Gerhardt GA (2007) Chronic second-by-second measures of l-glutamate in the central nervous system of freely moving rats. J Neurochem 102:712–722CrossRefGoogle Scholar
  24. Hsueh CC, Brajter TA (1994) A electrochemical preparation and analytical applications of ultrathin over-oxidized polypyrrole films. Anal Chem 66:2458–2464CrossRefGoogle Scholar
  25. Huffman ML, Venton BJ (2009) Carbon-fiber microelectrodes for in vivo applications. Analyst 134:18–24CrossRefGoogle Scholar
  26. Hughes G, Pemberton RM, Fielden PR, Hart JP (2016) The design, development and application of electrochemical glutamate biosensors. Trends Anal Chem 79:106–113CrossRefGoogle Scholar
  27. Jamal M, Worsfold O, McCormac T, Dempsey E (2009) A stable and selective electrochemical biosensor for the liver enzyme alanine aminotransferase (ALT). Biosens Bioelectron 24:2926–2930CrossRefGoogle Scholar
  28. Jamal M, Xu J, Razeeb KM (2010) Disposable biosensor based on immobilisation of glutamate oxidase on Pt nanoparticles modified Au nanowire array electrode. Biosens Bioelectron 26:1420–1424CrossRefGoogle Scholar
  29. Jamal M, Hasan M, Mathewson A, Razeeb KM (2013) Disposable sensor based on enzyme-free Ni nanowire array electrode to detect glutamate. Biosens Bioelectron 40:213–218CrossRefGoogle Scholar
  30. Kiyatkin EA, Wakabayashi KT, Lenoiry M (2013) Physiological fluctuations in brain temperature as a factor affecting electrochemical evaluations of extracellular glutamate and glucose in behavioral experiments. ACS Chem Neurosci 4:652–665CrossRefGoogle Scholar
  31. Kulagina NV, Michael AC (2003) Monitoring hydrogen peroxide in the extracellular space of the brain with amperometric microsensors. Anal Chem 75:4875–4881CrossRefGoogle Scholar
  32. Kulagina NV, Shankar L, Michael AC (1999) Monitoring glutamate and ascorbate in the extracellular space of brain tissue with electrochemical microsensors. Anal Chem 71:5093–5100CrossRefGoogle Scholar
  33. Kusakabe H, Midorikawa Y, Fujishima T, Kuninaka A, Yoshino H (1983) Purification and properties of a new enzyme, l-glutamate oxidase, from Streptomyces sp. X-l1.9-6 grown on wheat bran. Agric Biol Chem 47:1323–1328Google Scholar
  34. Kwong W, Gründig B, Hu J, Renneberg R (2000) Comparative study of hydrogel-immobilized l-glutamate oxidases for a novel thick-film biosensor and its application in food samples. Biotechnol Lett 22:267–272CrossRefGoogle Scholar
  35. McMahon CP, O’Neill RD (2005) Polymer-enzyme composite biosensor with high glutamate sensitivity and low oxygen dependence. Anal Chem 77:1196–1199CrossRefGoogle Scholar
  36. Mizutani F, Sato Y, Sawaguchi T, Yabuki S, Iijima S (1998) Rapid measurement of transaminase activities using an amperometric. l-Glutamate-sensing electrode based on a glutamate oxidase- polyion complex-bilayer membrane. Sens Actuators B Chem 52:23–29CrossRefGoogle Scholar
  37. Moore RB (1988) Chemical and morphological properties of solution-cast perfluorosulfonate ionomers. Macromolecules 21:1334–1339CrossRefGoogle Scholar
  38. Morita H, Abe C, Awazu C, Tanaka K (2007) Long-term hypergravity induces plastic alterations in vestibulo-cardiovascular reflex in conscious rats. Neurosci Lett 412:201–205CrossRefGoogle Scholar
  39. Oldenziel WH, Westerink BC (2005) Improving glutamate microsensors by optimizing the composition of the redox hydrogel. Anal Chem 77:5520–5528CrossRefGoogle Scholar
  40. Oldenziel WH, Dijkstra G, Cremers T, Westerink B (2006) Evaluation of hydrogel-coated glutamate microsensor. Anal Chem 78:3366–3378CrossRefGoogle Scholar
  41. Ozel RM, Hayat A, Andreescu S (2015) Recent developments in electrochemical sensors for the detection of neurotransmitters for applications in biomedicine. Anal Lete 44:1044–1069CrossRefGoogle Scholar
  42. Özel RE, Ganesana CM, Leiter JC, Andreescu S (2014) Glutamate oxidase biosensor based on mixed ceria and titania nanoparticles for the detection of glutamate in hypoxic environments. Biosens Bioelectron 52:397–402CrossRefGoogle Scholar
  43. Qin S, Zeyden MV, Oldenziel WH, Cremers TH, Westerink BC (2008) Microsensors for in vivo measurement of glutamate in brain tissue. Sensors 8:6860–6884CrossRefGoogle Scholar
  44. Rahman MA, Kwon N, Won M, Choe ES, Shim Y (2005) Functionalized conducting polymer as an enzyme-immobilizing substrate: an amperometric glutamate microbiosensor for in vivo measurements. Anal Chem 77:4854–4860CrossRefGoogle Scholar
  45. Ricci A, Amine A, Moscone D, Palleschi G (2007) A probe for NADH and H2O2 amperometric detection at low applied potential for oxidase and dehydrogenase based biosensor applications. Biosens Bioelectron 22:854–862CrossRefGoogle Scholar
  46. Rutherford EC, Pomerleau F, Huettl P, Strömberg I, Gerhardt GA (2007) Chronic second-by-second measures of l-glutamate in the central nervous system of freely moving rats. J Neurochem 102:712–722CrossRefGoogle Scholar
  47. Ryan MR, Lowry JP, O’Neill RD (1998) Behaviorally induced changes in extracellular levels of brain glutamate monitored at 1 s resolution with an implanted biosensor. Anal Commun 35:87–89CrossRefGoogle Scholar
  48. Samuels S (1999) The toxicity/safety of MSG: a study in suppression of information. Account Res 6:259–310CrossRefGoogle Scholar
  49. Shin MC, Kim HS (1996) Electro-chemical characterization of polypyrrole/glucose oxidase biosensor: optimal preparation conditions for the biosensor. Biosens Bioelectron 11:171–178CrossRefGoogle Scholar
  50. Sirca D, Vardeu A, Pinna M, Diana M, Enrico P (2014) A robust, state-of-the-art amperometric microbiosensor for glutamate detection. Biosens Bioeletron 61:526–531CrossRefGoogle Scholar
  51. Swanepoel E, Villiers MMD, Preez JL (1996) Fluorimetric method of analysis for d-norpseudoephedrine hydrochloride, glycine and l-glutamic acid by reversed-phase high-performance liquid chromatography. J Chromatogr 729:287–291CrossRefGoogle Scholar
  52. Tang L, Zhu Y, Xu L, Yang X, Li C (2007) Amperometric glutamate biosensor based on self-assembling glutamate dehydrogenase and dendrimer-encapsulated platinum nanoparticles onto carbon nanotubes. Talanta 73:438–443CrossRefGoogle Scholar
  53. Tian F, Gourine AV, Huckstepp RT, Dale N (2009) A microelectrode biosensor for real time monitoring of l-glutamate release. Anal Chim Acta 645:86–91CrossRefGoogle Scholar
  54. Tseng TT, Chang CF, Chan WC (2014) Fabrication of implantable, enzyme-immobilized glutamate sensors for the monitoring of glutamate concentration changes in vitro and in vivo. Molecules 19:7341–7355CrossRefGoogle Scholar
  55. Umana M, Waller J (1986) Protein-modified electrodes, the glucose oxidase/polypyrrole system. Anal Chem 58:2979–2983CrossRefGoogle Scholar
  56. Valero E, Carmona FG (1998) A continuous spectrophotometric method based on enzymatic cycling for determining l-glutamate. Anal Biochem 259:265–271CrossRefGoogle Scholar
  57. Wang J, Chen S, Lin M (1989) Use of different electro-polymerization conditions for controlling the size-exclusion selectivity at polyaniline, polypyrrole and polyphenol films. J Electroanal Chem 273:231–242CrossRefGoogle Scholar
  58. Wassum KM, Tolosa VM, Wang J, Harold EW, Monbouquette G, Maidment NT (2008) Silicon wafer-based platinum microelectrode array biosensor for near real-time measurement of glutamate in vivo. Sensors 8:5023–5036CrossRefGoogle Scholar
  59. Wei W, Song Y, Wang L, Zhang S, Luo J, Xu S, Cai X (2015) An implantable microelectrode array for simultaneous l-glutamate and electrophysiological recordings in vivo. Microsyst Nanoeng 1:15002–15008CrossRefGoogle Scholar
  60. Weltin A, Kieninger J, Enderle B, Gellner AK, Fritsch B, Urban GA (2014) Polymer-based, flexible glutamate and lactate microsensors for in vivo applications. Biosens Bioelectron 61:192–199CrossRefGoogle Scholar
  61. Zook LA, Leddy J (1996) Density and solubility of Nafion: recast, annealed, and commercial films. Anal Chem 68:3793–3796CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of ChemistryKhulna University of Engineering and TechnologyKhulnaBangladesh
  2. 2.Department of Mechanical System Engineering, Graduate School of Science and EngineeringYamagata UniversityYonezawaJapan
  3. 3.Micro-Nano Systems Centre, Tyndall National InstituteUniversity College CorkCorkIreland

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