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Multicenter observational study on functional bowel disorders diagnosed using Rome III diagnostic criteria in Japan

  • Original Article—Alimentary Tract
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Abstract

Background

The Rome III diagnostic criteria had been used to diagnose functional gastrointestinal disorders (FGIDs) world wide, and functional bowel disorders (FBDs) including irritable bowel syndrome (IBS) have recently attracted the attention of Japanese physicians. However, there have been few reports on the prevalence of FBDs diagnosed by the Rome III diagnostic criteria.

Aims

The aim of this study was to determine the prevalence of FBDs diagnosed according to the diagnostic criteria of Rome III in Japan.

Patients and methods

All patients who were booked for colonoscopy were enrolled from eight institutions in Japan. This study was a prospective observational study in the period from April 2013 to December 2013. Patients filled out FGID questionnaires of Rome III when they were waiting for colonoscopy.

Results

Data for 1200 patients who underwent colonoscopy were analyzed. A total of 547 patients (45.6%) were diagnosed with FBDs. Out of those patients, 9.1% had IBS. According to the Rome III diagnostic criteria, 134 patients (11.2%) had functional bloating (FB), 73 (6.1%) had functional constipation (FC), 40 (3.3%) had functional diarrhea (FD), and 191 (15.9%) had unspecified functional bowel disorder (UFBD). Patients with FBDs had significantly higher rates of almost all symptoms (abdominal pain, hard or lumpy stools, loose or watery stools, and bloating) than those in the controls.

Conclusions

In Japan, the prevalence of FBDs and IBS is high, similar to that in the US. Many patients with FBDs have multiple symptoms.

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Abbreviations

CS:

Colonoscopy

FAPS:

Functional abdominal pain syndrome

FB:

Functional bloating

FBDs:

Functional bowel disorders

FC:

Functional constipation

FD:

Functional diarrhea

FGIDs:

Functional gastrointestinal disorders

IBD:

Inflammatory bowel disease

IBS:

Irritable bowel syndrome

UFBD:

Unspecified functional bowel disorder

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Acknowledgements

We wish to thank Dr. Uehara and Dr. Hokari for participation this study. Mototsugu Kato has served in speaking and teaching commitments for Eisai Co., Ltd., Daiichi Sankyo Company, Ltd., Takeda Pharmaceutical Co. Ltd., Otsuka Pharmaceutical Co., Ltd. and AstraZeneca and has received scholarship grants from Eisai Co., Ltd., Takeda Pharmaceutical Co. Ltd., Daiichi Sankyo Company, Ltd., AstraZeneca and Astellas Pharma Inc. Sakamoto received a research grant from Daiichi-Sankyo, Gilead Sciences, and MSD, and received lecture fees from Bristol-Myers-Squibb, Gilead Sciences, MSD, Otsuka Pharmaceutical, and AbbVie.

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Authors and Affiliations

  1. Department of Gastroenterology, Hakodate Municipal Hospital, 1-10-1 Minato-cho, Hakodate, Hokkaido, 041-8680, Japan

    Masayoshi Ono

  2. Department of Gastroenterology, National Hospital Organization Hakodate Hospital, Hakodate, Japan

    Mototsugu Kato & Katsuhiro Mabe

  3. Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Shuichi Miyamoto, Momoko Tsuda, Takeshi Mizushima & Naoya Sakamoto

  4. Division of Endoscopy, Hokkaido University Hospital, Sapporo, Japan

    Shouko Ono, Manabu Nakagawa, Soichi Nakagawa & Yuichi Shimizu

  5. Department of Gastroenterology, National Hospital Organization, Hokkaido Medical Center, Sapporo, Japan

    Shuichi Muto

  6. Department of Gastroenterology, Touei Hospital, Sapporo, Japan

    Mineo Kudo

  7. Center of Gastroenterology, Otaru Ekisaikai Hospital, Otaru, Japan

    Shinichi Katsuki

  8. Department of Gastroenterology, Hokkaido Gastroenterology Hospital, Sapporo, Japan

    Takashi Meguro

Authors
  1. Masayoshi Ono
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  2. Mototsugu Kato
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  7. Manabu Nakagawa
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  8. Katsuhiro Mabe
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  9. Soichi Nakagawa
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  10. Shuichi Muto
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  11. Yuichi Shimizu
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  12. Mineo Kudo
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  13. Shinichi Katsuki
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  15. Naoya Sakamoto
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Corresponding author

Correspondence to Masayoshi Ono.

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Ono, M., Kato, M., Miyamoto, S. et al. Multicenter observational study on functional bowel disorders diagnosed using Rome III diagnostic criteria in Japan. J Gastroenterol 53, 916–923 (2018). https://doi.org/10.1007/s00535-017-1428-9

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  • DOI: https://doi.org/10.1007/s00535-017-1428-9

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