Abstract
Background
This meta-analysis systematically evaluated the efficacy of Traditional Chinese Medicine (TCM) combined with chemotherapy and provided evidence-based evidence for the treatment of non-small cell lung cancer.
Methods
Biomedical databases including China National Knowledge Infrastructure (CNKI) database, Wanfang Database, PubMed, and Cochrane Library were searched from January 2005 to October 2019 for the clinical literature on Chinese medicine for treating non-small cell lung cancer. All randomized controlled trials (RCTs) concerning the TCM combined with chemotherapy for non-small cell lung cancer were selected. The total effective rate of clinical efficacy, quality of life (QOL), Karnofsky Performance Status (KPS) score, adverse drug reactions (ADRs) were extracted and analyzed. Review Manager 5.3 software was used for heterogeneity testing and combined statistical analysis.
Results
A total of 20 RCTs were included, with a total sample of 1669 cases, including 845 in the experimental group (TCM combined with chemotherapy) and 824 in the control group (chemotherapy alone). Compared with the control group, the experimental group significantly improved patients’ QOL [OR = 2.79, 95% CI (1.87, 4.16), P < 0.00001], improved clinical efficacy [OR = 2.88, 95% CI (2.32, 3.58), P < 0.00001], increased KPS score [OR = 2.88, 95% CI (1.79, 4.62), P < 0.00001], and reduced the incidence of leukopenia [OR = 0.21, 95% CI (0.12, 0.37), P < 0.0001], thrombocytopenia [OR = 0.23, 95% CI (0.13, 0.40), P < 0.00001], hemoglobin reduction [OR = 0.17, 95% CI (0.10, 0.30), P < 0.00001], myelosuppression [OR = 0.24, 95% CI (0.10, 0.58), P < 0.001], nausea and vomiting [OR = 0.16, 95% CI (0.11, 0.22), P < 0.00001], diarrhea [OR = 0.21, 95% CI (0.12, 0.37), P < 0.00001], liver damage [OR = 0.17, 95% CI (0.10, 0.27), P < 0.00001], and kidney damage [OR = 0.30, 95% CI (0.10, 0.90), P = 0.03].
Conclusion
TCM combined with chemotherapy can improve clinical efficacy and KPS score, as well as improve patients’ QOL and reduce ADRs caused by chemotherapy drugs.
Similar content being viewed by others
References
Barta JA, Powell CA, Wisnivesky JP (2019) Global epidemiology of lung cancer. Ann Global Health 85(1):8–53
Christy WS, Tong WKKW (2017) Drug combination approach to overcome resistance to EGFR tyrosine kinase inhibitors in lung cancer. Cancer Lett 405(1):100–110
Uchibori K et al (2017) Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer. Nat Commun 8(1):14768–14800
Yang Dan TG (2009) Experimental research progress of traditional Chinese medicine in the treatment of lung cancer. Chin J Ttradit Chin Med 34(18):2405–2409
Xianzhong L (2019) Clinical observation of chemotherapy combined with traditional Chinese Medicine in the treatment of 35 elderly patients with advanced non-small cell lung cancer. J Qiannan Med College National 32(01):25–27
Zhongqing W (2019) Clinical observation of Yiqi Yangyin Huatan jiedu traditional Chinese Medicine in the treatment of Middle and Advanced non-small Cell Lung Cancer. J Shanxi Med College 29(04):72–74
Li Qun XPXM (2019) Effect of integrated traditional Chinese and western medicine on efficacy, side effects and KPS score of patients with non-small cell lung cancer. Modern J Integr Tradit Chin West Med 28(09):991–993
Xiaoying W (2019) Clinical observation of combination of traditional Chinese and Western Medicine in the treatment of advanced non-small cell lung cancer. World Latest Med Inf 19(5):164–165
Gu Zhibin LL (2019) Effect of combination of traditional Chinese and Western medicine in the treatment of patients with advanced non-small cell lung cancer. J Clin Med Pract 23(9):13–15,19
Tao W (2018) Clinical study on the efficacy of synergistic and attenuated action of Yiqi Fuzheng herbs on chemotherapy in the patients with non - small cell lung cancer. World J Integr Tradit West Med 13(05):642–645
Qingchun L et al (2017) Clinical efficacy of Jianpi Yiqi herbs combined with chemotherapy in the treatment of advanced non-small cell lung cancer. Clin J Med Offic 45(11):1186–1188
Xu Yongmei YGHF (2017) Observation on clinical effects of Chinese medicine assisted arterial infusion chemotherapy in the treat-ment of 53 cases of advanced non-small cell lung Cancer. J Tradit Chin Med 58(2):138–142
Chengjie, L., Invigorating qi and warming yang method combined chemotherapy in the treatment of middle-late stage non-small cell lung cancer clinical research. 2017, Nanjing University of traditional Chinese Medicine. p. 55
Hua J (2017) Clinical observation on the treatment of senile advanced non-small cell lung cancer with combination of traditional Chinese and Western Medicine. People's Mil Surg 60(1):47–49
Wei X (2017) Observation on the therapeutic effect of combination of traditional Chinese and Western medicine on advanced non-small cell lung cancer. J Pract Ttradit Chin Med 33(9):1054–1055
Liu Jintao GL (2016) Short-term efficacy of combination of traditional Chinese and Western medicine in the treatment of non-small cell lung cancer. Latest Med Inf Abstracts World 16(2):147
Wang Bijuan GQ (2016) Clinical observation on treatment of non-small cell lung cancer with combination of traditional Chinese and Western medicine. J New Chin Med 10(48):163–165
Zhi L (2016) Observation on the therapeutic effect of combination of traditional Chinese and Western medicine on advanced non-small cell lung cancer. China Prac Med 11(27):247–248
Hui L et al (2012) Clinical observation of traditional Chinese Medicine combined with docetaxel in the treatment of 36 cases of advanced non-small cell lung cancer. J New Chin Med 44(06):111–114
Dengxiang L et al (2012) Clinical study on improvement of quality of life and short-term efficacy of traditional Chinese medicine in patients with advanced non-small cell lung cancer. Chin J Basic Med Tradit Chin Med 18(11):1239–1241
Yanli H et al (2012) Clinical study of traditional Chinese medicine for nourishing yin, clearing heat and detoxification combined with chemotherapy in the treatment of advanced non-small cell lung cancer. Liaoning J Tradit Chin Med 39(02):303–305
Yanli H et al (2011) Clinical study on the effect of traditional Chinese Medicine of replenishing Qi and Nourishing Yin on advanced non-small cell lung cancer treated with GP regimen. J New Chin Med 43(09):47–49
Yan-zhi C, Zhan-dong L, Gao F, Zhang Y, Sun H, Ping-ping L (2009) Effects of combined Chinese drugs and chemotherapy in treating advanced non-small cell lung cancer. Chin J Integr Med 15(6):415–419
Xiaoxia G, Yuhua T, Shulin L (2005) clinical observation of Jisheng powder combined with Shenmai injection in the treatment of advanced non-small cell lung cancer. Liaoning J Tradit Chin Med 32(11):1142–1144
Wang Cong Cong, L.H.Z.J., Efficacy and safety of Traditional Chinese Medicine combined with concurrent chemoradiotherapy in treatment of advanced non - small cell lung cancer: a meta - analysis. Chinese general practice, 2015. 18(12): p. 1406–1414
Junde L, Jianfeng Q (2018) a review of the combination of traditional Chinese and Western medicine in the treatment of middle and advanced non-small cell lung cancer. Henan Tradit Chin Med 38(2):317–320
Liu Z-l, Zhu W-r, Zhu W-c, Ying H-f, Zheng L, Guo Y-b, Chen J-x, Shen X-h (2014) Traditional Chinese medicinal herbs combined with epidermal growth factor receptor tyrosine kinase inhibitor for advanced non-small cell lung cancer: a systematic review and meta-analysis. J Integr Med 12(4):346–358
Funding
This study was supported by the National Natural Science Foundation of China (81402186); the Shaanxi Natural Science Foundation (2019JQ-878), the Youth fund of Shaanxi University of Traditional Chinese Medicine (2015QN18), and the Team fund of Shaanxi University of Traditional Chinese Medicine (2019-YL13).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Yang, J., Zhu, X., Yuan, P. et al. Efficacy of traditional Chinese Medicine combined with chemotherapy in patients with non-small cell lung cancer (NSCLC): a meta-analysis of randomized clinical trials. Support Care Cancer 28, 3571–3579 (2020). https://doi.org/10.1007/s00520-020-05433-w
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00520-020-05433-w