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Biological predictors of chemotherapy-induced peripheral neuropathy (CIPN): MASCC neurological complications working group overview

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Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating condition associated with a number of chemotherapeutic agents. Drugs commonly implicated in the development of CIPN include platinum agents, taxanes, vinca alkaloids, bortezomib, and thalidomide analogues. As a drug response can vary between individuals, it is hypothesized that an individual’s specific genetic variants could impact the regulation of genes involved in drug pharmacokinetics, ion channel functioning, neurotoxicity, and DNA repair, which in turn affect CIPN development and severity. Variations of other molecular markers may also affect the incidence and severity of CIPN. Hence, the objective of this review was to summarize the known biological (molecular and genomic) predictors of CIPN and discuss the means to facilitate progress in this field.

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Authors and Affiliations

  1. National University of Singapore, Singapore, Singapore

    Alexandre Chan & Chia Jie Tan

  2. National Cancer Centre Singapore, Singapore, Singapore

    Alexandre Chan & Chia Jie Tan

  3. University of Michigan, Ann Arbor, USA

    Daniel L. Hertz

  4. University Hospital Ntra. Sra. de Candelaria, Santa Cruz de Tenerife, Spain

    Manuel Morales

  5. The Ohio State University Comprehensive Cancer Center, Columbus, USA

    Elizabeth J. Adams & Maryam B. Lustberg

  6. University of Connecticut, Storrs, USA

    Sharon Gordon

  7. East Carolina University, Greenville, USA

    Sharon Gordon

  8. Mayo Clinic Rochester, Florida, USA

    Nathan P. Staff, Andreas S. Beutler & Charles Loprinzi

  9. University of Connecticut Health Center, Storrs, USA

    Jayesh Kamath

  10. MD Anderson Cancer Center, Houston, USA

    Jeong Oh, Linda Pang & Ishwaria Subbiah

  11. University of Colorado, Colorado, USA

    Shivani Shinde

  12. VA Eastern Colorado Health Care Systems, Aurora, MS, USA

    Shivani Shinde

  13. Western University of Health Sciences, Pomona, USA

    Doreen Pon

  14. University of California San Francisco, San Francisco, USA

    Niharkia Dixit & Kord Kober

  15. Zuckerberg San Francisco General Hospital, San Francisco, USA

    Niharkia Dixit

  16. Northwell Cancer Institute, New Hyde Park, USA

    James D’Olimpio

  17. Zucker School of Medicine at Hofstra, 500 Hofstra Blvd, Hempstead, USA

    James D’Olimpio

  18. Marie Curie Hospital, , London, UK

    Cristina Dumitrescu

  19. University of Trieste, Trieste, Italy

    Margherita Gobbo

  20. Helen Diller Comprehensive Cancer Centre, San Francisco, USA

    Kord Kober

  21. University of Toronto, Toronto, Canada

    Samantha Mayo

  22. Preston Robert Tisch Brain Tumor Centre, Durham, USA

    Katherine B. Peters

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  1. Alexandre Chan
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  2. Daniel L. Hertz
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Correspondence to Maryam B. Lustberg.

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This project was not specifically funded by any organization, but a couple of the investigators are generally funded by the National Institutes of Health/National Cancer Institute (R01CA211887, R01CACA189947)

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Chan, A., Hertz, D.L., Morales, M. et al. Biological predictors of chemotherapy-induced peripheral neuropathy (CIPN): MASCC neurological complications working group overview. Support Care Cancer 27, 3729–3737 (2019). https://doi.org/10.1007/s00520-019-04987-8

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