Supportive Care in Cancer

, Volume 25, Issue 12, pp 3603–3605 | Cite as

Evidence of depression-associated circadian rhythm disruption and regret in prostate cancer patients after surgery

  • Joanne Christie
  • Christopher F Sharpley
  • Vicki Bitsika
  • David Christie



The purpose of this study is to investigate the association between prostate cancer (PCa) patients’ regret that their surgery harmed them, and their scores on the two key symptoms of major depressive disorder (depressed mood, anhedonia) and a symptom of melancholic depression (disruption to circadian rhythm).


Forty PCa patients who had received surgery for their PCa completed a postal survey including background information, regret about surgery that ‘did them a lot of harm’ and three items drawn from the Zung Self-Rating Depression Scale measuring depressed mood, anhedonia and circadian rhythm disruption.


There were significant correlations between all three symptoms of depression (depressed mood, anhedonia, disruption to circadian rhythm) and between patients’ regret that surgery did them a lot of harm and their circadian rhythm disruption, but not between depressed mood or anhedonia and regret about surgery doing harm.


These findings suggest that PCa patients’ post-surgery regrets about major harm may lead to a significant disruption in a central physiological function and raise the need to consider this side effect of surgery when planning supportive services for these men.


Prostate cancer Surgery Regrets Melancholia Circadian rhythm 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Joanne Christie
    • 1
  • Christopher F Sharpley
    • 2
  • Vicki Bitsika
    • 3
  • David Christie
    • 2
    • 4
  1. 1.Griffith UniversityGold CoastAustralia
  2. 2.Brain-Behaviour Research GroupUniversity of New EnglandArmidaleAustralia
  3. 3.Centre for Autism Spectrum DisorderBond UniversityGold CoastAustralia
  4. 4.Genesis CancercareGold CoastAustralia

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