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Impact of family structure on long-term survivors of osteosarcoma

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Abstract

Goals of work

Long-term outcomes of osteosarcoma have dramatically improved with the use of modern combination therapies. Such aggressive treatments, however, entail chronic complications. In the present study, we assessed the functional, psychological, and familial status of long-term survivors of osteosarcoma treated at our institution.

Materials and methods

Fifteen long-term survivors of osteosarcoma were evaluated for functional and psychological sequelae. Functional assessment was based on a method described by Enneking et al. Psychological assessment was based on General Health Questionnaire 28, Inventory Scale for Traumatic Neurosis, and Family System Test.

Main results

Ten patients showed mild functional impairments; only five patients were handicapped more seriously. Depressive symptoms were diagnosed in four patients. A total of six patients revealed unbalanced family structures, including three of the four patients with depressive symptoms, all four patients with symptoms of posttraumatic stress disorder, and five of seven patients who showed poor emotional acceptance.

Conclusions

Osteosarcoma survivors will generally recover good functional performance. Only a minority of them remain seriously impaired. One third of the patients present depressive symptoms and posttraumatic stress disorder. Poor coping is closely associated with unbalanced family structures. Therefore, the psychological and familial situation of patients with newly diagnosed osteosarcoma should be carefully assessed.

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References

  1. Aksnes LH, Hall KS, Folleraas G, Stenwig AE, Bjerkehagen B, Taksdal I, Winderen M, Bruland OS, Saeter G (2006) Management of high-grade bone sarcomas over two decades: the Norwegian Radium Hospital experience. Acta Oncol 45(1):38–46

    Article  PubMed  Google Scholar 

  2. Babin SR, Simon P, Babin-Boilletot A, Bellocq JP, Marcellin L, Dosch JC (1996) Complications and results in high-grade osteosarcoma of the lower limb. A study of 20 cases. Rev Chir Orthop 82:14–21

    PubMed  CAS  Google Scholar 

  3. Bielack SS, Kempf-Bielack B, Delling G, Exner U, Flege S, Helmke K, Katz R, Werner M, Winkelmann W, Zoubek A, Jurgens H (2002) Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol 20:776–790

    Article  PubMed  Google Scholar 

  4. Bolognini M, Bettschart W, Zehnder-Gubler M, Rossier L (1989) The validity of the French version of the GHQ-28 and PSYDIS in a community sample of 20 year olds in Switzerland. Eur Arch Psychiatr Neurol Sci 238(3):161–168

    Article  CAS  Google Scholar 

  5. Boman K, Bodegard G (1995) Psychological long-term coping with experience of treatment in childhood cancer survivors. Acta Paediatr 84:1395–1402

    PubMed  CAS  Google Scholar 

  6. Bordmann AP (1987) The general health questionnaire and the detection of emotional disorder by general practitioners, a replicated study. Br J Psychiatry 151:373–381

    Article  Google Scholar 

  7. Cameron KT (1993) Psychological effects of amputation in osteosarcoma. In: Osteosarcoma in adolescents and young adults. Kluwer, Boston, pp 39–44

    Google Scholar 

  8. Enneking WF, DunHam W, Gebhardt MC, Malawar M, Pritchard DJ (1993) A system for functional evaluation of reconstructive procedures after surgical treatment of tumors of the musculoskeletal system. Clin Orthop Relat Res 286:241–246

    PubMed  Google Scholar 

  9. Fritz GK, Williams JR, Amylon M (1988) Psychosocial sequelae in pediatric cancer survivors. Am J Orthopsychiatr 58(4):552–561

    Article  CAS  Google Scholar 

  10. Gehring T. Family System Test (FAST), Authorized English translation by Anita Arone Reitzle, Zurich, Switzerland. First publication in 1993 By Beltz Verlag, Germany, under the title of Familiensystemtest (FAST). Copyright Beltz Gessellschaft

  11. Greenberg DB, Goorin A, Gebhardt MC, Gupta L, Stier N, Harmon D, Mankin H (1994) Quality of life in osteosarcoma survivors. Oncology 8(11):19–25

    PubMed  CAS  Google Scholar 

  12. Hobbie WL, Stuber M, Meeske K, Wissler K, Rourke M, Ruccione K, Hinkle A, Kazak AE (2000) Symptoms of posttraumatic stress in young adult survivors of childhood cancer. J Clin Oncol 18:4060–4066

    PubMed  CAS  Google Scholar 

  13. Hudson MM, Mertens AC, Yasui Y, Hobbie W, Chen H, Gurney JG, Yeazel M, Recklitis CJ, Marina N, Robinson L, Oeffinger K (2003) Health status of adult long-term survivors of childhood cancer. JAMA 290:1583–1592

    Article  PubMed  CAS  Google Scholar 

  14. Kazak AE, Meadows AT (1989) Families of young adolescents who have survived cancer: socio-emotional adjustment, adaptability and social support. J Pediatr Psychol 14:175–191

    Article  PubMed  CAS  Google Scholar 

  15. Koopmann HM, Koetsier JA, Taminiau AH, Hijnen KE, Bresters D, Egeler RM (2005) Health-related quality of life and coping strategies of children after treatment of a malignant bone tumor: a 5-year follow-up study. Pediatr Blood Cancer 45:694–699

    Article  Google Scholar 

  16. Maunsell E, Pogany L, Barrera M, Shaw AK, Speechley KN (2006) Quality of life among long-term adolescent and adult survivors of childhood cancer. J Clin Oncol 24:2527–2535

    Article  PubMed  Google Scholar 

  17. Nagarajan R, Neglia JP, Clohisy DR, Yasui Y, Greenberg M, Hudson M, Zevon M, Tersak JM, Albin A, Robinson LL (2003) Education, employment, insurance, and marital status among 694 survivors of pediatric lower extremity bone tumors. Cancer 97:2554–2564

    Article  PubMed  Google Scholar 

  18. Nicholson HC, Mulvihill JJ (1993) Late effects of therapy in survivors of childhood and adolescent osteosarcoma. Cancer Treat Res 62:45–48

    PubMed  CAS  Google Scholar 

  19. Pardasaney PK, Sullivan PE, Portney LG, Mankin HJ (2006) Advantage of limb salvage over amputation for proximal lower extremity tumors. Clin Orthop Relat Res 444:201–208

    Article  PubMed  Google Scholar 

  20. Perey L, Guillou L, Jallut D, Beck D, Livio JJ, Leyvraz S (1995) Traitement combiné des ostéosarcomes: expérience lausannoise. Méd et Hyg 53:2318–2324

    Google Scholar 

  21. Real del Sarte O (1996) Psychosomatique et chronicité débat autour d’une recherche. Thér Fam 17:225–239

    Google Scholar 

  22. Real del Sarte O, Stiefel F, Leyvraz S, Bauer J, Gehring TM, Guex P (1998) The Family System Test, a pilot study in families with a young adult member with cancer. Support Care Cancer 6:416–420

    Article  Google Scholar 

  23. Rolland JS (1987) Chronic illness and the life cycle. Fam Proc 26:203–221

    Article  CAS  Google Scholar 

  24. Rougraff BT, Simon MA, Kneisl JS, Greenberg DB, Mankin HJ (1994) Limb salvage compared with amputation for osteosarcoma of the distal end of the femur. J Bone Jt Surg 76-A:649–656

    Google Scholar 

  25. Schwartz CL (2003) Health status of childhood cancer survivors. Cure is more than the eradication of cancer. JAMA 290:1641–1643

    Article  PubMed  CAS  Google Scholar 

  26. Schwartz L, Drotar D (2006) Posttraumatic stress and related impairment in survivors of childhood cancer in early adulthood compared to healthy peers. J Pediatr Psychol 31:356–366

    Article  PubMed  Google Scholar 

  27. Steinitz A, Crocq L (1992) L’inventaire-échelle de névrose traumatique. Psychol Méd 24:437–445

    Google Scholar 

  28. Taieb O, Moro MR, Baubet T, Revah-Levy A, Flament MF (2003) Posttraumatic stress symptoms after childhood cancer. Eur Child Adolesc Psychiatry 12:255–264

    Article  PubMed  Google Scholar 

  29. Wasserman AL, Thompson EI, Williams JA, Fairclough DL (1987) The psychological status of survivors of childhood/adolescent Hodgkin’s disease. Am J Dis Child 141(6):626–631

    PubMed  CAS  Google Scholar 

  30. Weddington WW Jr, Segraves KB, Simon MA (1985) Psychological outcome of extremity sarcoma survivors undergoing amputation or limb salvage. J Clin Oncol 3:1393–1399

    PubMed  Google Scholar 

  31. Wood B, Watkins JB, Boyle JT (1989) The psychosomatic family model, an empirical and theoretical analysis. Fam Proc 28:399–417

    Article  CAS  Google Scholar 

  32. Zebrack BJ, Zeltzer LK, Whitton J, Mertens AC, Odom L, Berkow R, Robinson LL (2002) Psychological outcomes in long-term survivors of childhood leukaemia, Hodgkin’s disease, and non-Hodgkin’s lymphoma. Pediatrics 110:42–52

    Article  PubMed  Google Scholar 

  33. Zebrack BJ, Zevon MA, Turk N, Nagarajan R, Whitton J, Robinson LL, Zeltzer LK (2006) Psychological distress in long-term survivors of solid tumors diagnosed in childhood: a report from the childhood cancer survivor study. Pediatr Blood Cancer, Jun 5; [Epub ahead of print]

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Authors and Affiliations

  1. Department of Clinical Oncology, Hôpital Pourtalès, Neuchâtel, Switzerland

    A. Bressoud

  2. Department of Psychiatry, University Hospital Center, Lausanne, Switzerland

    O. Real del Sarte & S. Stiefel

  3. Department of Orthopedics, University Hospital Center, Lausanne, Switzerland

    P. Mordasini & P. F. Leyvraz

  4. Department of Clinical Oncology, University Hospital Center, Lausanne, Switzerland

    L. Perey, J. Bauer & S. Leyvraz

  5. Centre Pluridiciplinaire d’Oncologie, University Hospital Center (CHUV-06), 1011, Lausanne, Switzerland

    S. Leyvraz

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  1. A. Bressoud
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  2. O. Real del Sarte
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  3. S. Stiefel
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  4. P. Mordasini
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  7. P. F. Leyvraz
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Correspondence to S. Leyvraz.

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Bressoud, A., Real del Sarte, O., Stiefel, S. et al. Impact of family structure on long-term survivors of osteosarcoma. Support Care Cancer 15, 525–531 (2007). https://doi.org/10.1007/s00520-006-0196-5

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  • DOI: https://doi.org/10.1007/s00520-006-0196-5

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