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Predictors of colonic pathologies in active acromegaly: single tertiary center experience

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Summary

Background

Regarding the incidence of colorectal malignancy and polyps in patients with acromegaly, studies reported different results in different populations. For this reason, the aim of this study was to determine the frequency of possible colonic pathologies, such as diverticula, polyps, and malignancies in Turkish patients with active acromegaly and factors affecting them.

Methods

A total of 134 patients with acromegaly and 134 patients with irritable bowel syndrome/dyspeptic symptoms as a control group were included in the study. None of these patients had a previous or family history of colonic neoplasms. Colonoscopies of patients with acromegaly were performed before definitive surgery in a single center by experienced endoscopists.

Results

The acromegaly and control groups were similar in terms of age and sex. The incidence of all colonic polyps was significantly higher in the acromegaly group (p = 0.012). The frequency of hyperplastic polyps was also increased in the acromegaly group (p = 0.004); however, the frequencies of adenomatous polyps and colonic diverticula were similar in both groups. In the comparison of patients with acromegaly for the presence of polyps, those with polyps were older, had higher levels of insulin-like growth factor (IGF-1), were of male sex, and skin tags were more common (p = 0.016, p = 0.034, p = 0.006 and p = 0.001, respectively). There were no colorectal malignancies in the patients with active acromegaly.

Conclusion

The frequency of hyperplastic polyps was increased, whereas colonic malignancy was not observed in Turkish patients with active acromegaly.

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Acknowledgements

Our thanks to Mr. David F. Chapman for language editing.

Funding

No funding was received.

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Authors and Affiliations

  1. Biruni Faculty of Medicine, Department of Gastroenterology, Biruni University, 34295, Istanbul, Turkey

    Raim Iliaz M.D.

  2. Istanbul Faculty of Medicine, Department of Endocrinology and Metabolism, Istanbul University, Istanbul, Turkey

    Sema Ciftci Dogansen, Seher Tanrikulu, Gulsah Yenidunya Yalin & Sema Yarman

  3. Istanbul Faculty of Medicine, Department of Gastroenterology, Istanbul University, Istanbul, Turkey

    Bilger Cavus & Filiz Akyuz

  4. Istanbul Faculty of Medicine, Department of Pathology, Istanbul University, Istanbul, Turkey

    Mine Gulluoglu

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  1. Raim Iliaz M.D.
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Correspondence to Raim Iliaz M.D..

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Conflict of interest

R. Iliaz , S.C. Dogansen, S. Tanrikulu, G.Y. Yalin, B. Cavus, M. Gulluoglu, F. Akyuz and S. Yarman declare that they have no competing interests.

Ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the local ethics committee (Ethics Committee of Istanbul Medical Faculty, 2017-377).

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Iliaz, R., Dogansen, S.C., Tanrikulu, S. et al. Predictors of colonic pathologies in active acromegaly: single tertiary center experience. Wien Klin Wochenschr 130, 511–516 (2018). https://doi.org/10.1007/s00508-018-1367-3

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