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Treatment of hemorrhagic gastritis by Ankaferd blood stopper versus Omeprazole: experimental randomized rat models

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Summary

Background

Ankaferd blood stopper (ABS) is a herbal extract that enhances mucosal healing. It has therapeutic potential in the management of external hemorrhage and controlling gastrointestinal bleeding associated with various benign lesions refractory to conventional antihemorrhagic measures. The aim of this experimental study was to assess the effects of ABS on hemorrhagic lesions and compare them with omeprazole.

Methods

The study was conducted on 30 rats. Rats were divided into five groups: group A (only indomethacin), group B (ABS administration 60 min before indomethacin-induced injury), group C (ABS administration 30 min after indomethacin-induced injury), group D (omeprazole administration 60 min before indomethacin‐induced injury), group E (omeprazole administration 30 min after indomethacin‐induced injury). Gastric mucosal lesions were produced by indomethacin in all three groups. The effect was studied morphologically 6 h after oral administration of the drug. Subsequently, affected tissue was examined histologically.

Results

Based on the number and the total size of hemorrhagic lesions, the hemorrhagic lesion scores were significantly better in Group C compared to other groups (p < 0.05). The hemorrhagic lesion score of Group B was significantly better than Group D and Group A (p < 0.05). Omeprazole groups (Group D, Group E) did not show significant improvement as indicated by macroscopic scores. There was no significant difference between the groups with respect to microscopic scores.

Conclusion

These results indicate that ABS has a potent inhibitory action on indomethacin-induced gastric bleeding and mucosal lesions and it is useful in the treatment of acute gastric mucosal lesions.

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Conflict of interest

No commercial party having a direct financial support, any conflicts of interest in the results of the research supporting this article has or will confer a benefit on the authors or on any organization with which the authors are associated. The authors declare that there are no actual or potential conflicts of interest in relation to this article.

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Authors and Affiliations

  1. Deparment of Internal Medicine, Ankara Education and Research Hospital, Ankara, Turkey

    Hikmetullah Batgi MD

  2. Department of Gastroenterology, Çanakkale Onsekiz Mart University, Çanakkale, Turkey

    Erdem Akbal MD

  3. Department of Gastroenterology, Çanakkale state Hospital, Çanakkale, Turkey

    Erdem Koçak MD

  4. Department of Internal Medicine, Mevlana University Faculty of Medicine, Konya, Turkey

    Ömer Akyürek MD

  5. Department of Gastroenterology, School of medicine Hacettepe University, Ankara, Turkey

    Seyfettin Köklü MD

  6. Department of Pathology, Ankara Education and Research Hospital, Ankara, Turkey

    Melahat Dönmez MD

  7. Department of Internal Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey

    Fahri Güneş

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  1. Hikmetullah Batgi MD
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  2. Erdem Akbal MD
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  3. Erdem Koçak MD
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  4. Ömer Akyürek MD
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Correspondence to Ömer Akyürek MD.

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Batgi, H., Akbal, E., Koçak, E. et al. Treatment of hemorrhagic gastritis by Ankaferd blood stopper versus Omeprazole: experimental randomized rat models. Wien Klin Wochenschr 128 (Suppl 8), 559–565 (2016). https://doi.org/10.1007/s00508-015-0762-2

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  • DOI: https://doi.org/10.1007/s00508-015-0762-2

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