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Heart transplantation in Vienna: 25 years of experience

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Summary

Since the beginning of the University of Vienna Cardiac Transplant Program in 1984, 1113 heart transplant procedures have been performed through August of 2008. One- and five-year survival has increased steadily over time (82% and 76%). Ten-year survival is 65%. Over the past 25 years our program has seen dramatic changes in patient selection, accepting now patients with more risk factors (e.g. age, diabetes, elevated pulmonary resistance). Developments in immunosuppression have decreased incidence of infection, rejection and graftarteriosclerosis continuously. Our program continues to pursue novel strategies to improve the survival and quality of life of our heart transplant patients.

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References

  • Laczkovics A, Havel M, Laufer G, Teufelsbauer H, Gollner C, Wolner E (1987) Orthotopic heart transplantation – experiences at the University Surgical Clinic II in Vienna (status: June 1986). Wien Klin Wochenschr 99(10): 333–40

    PubMed  CAS  Google Scholar 

  • Woloszczuk W, Schwarz M, Havel M, Laczkovics A, Müller MM (1986) Neopterin and interferon gamma serum levels in patients with heart and kidney transplants. J Clin Chem Clin Biochem 24 (10): 729–34

    PubMed  CAS  Google Scholar 

  • Hamilton G, Roth E, Mühlbacher F, Funovics J, Piza F, Schindler J, et al (1986) Measuring cyclosporin in immunosuppressive treatment following liver and heart transplantation. Wien Klin Wochenschr 98 (24): 820–4

    PubMed  CAS  Google Scholar 

  • Havel MP, Laczkovics AM, Kurz RW, Müller MM, Wolner E (1987) Neopterin as a parameter for the early detection of acute graft rejection following heart transplantation. Z Med Lab Diagn 28 (8): 429–435

    PubMed  CAS  Google Scholar 

  • Hamilton G, Mühlbacher F, Roth E, Wolf I, Piza F, Havel M, et al (1987) Comparison of cyclosporine A dosage and metabolism in liver and heart transplant recipients. Transplant Proc 19 (1 Pt 2): 1706–8

    PubMed  CAS  Google Scholar 

  • Trubel W, Losert U, Schima H, Rokitansky A, Spiss CK, Coraim F, et al (1987) Total artificial heart bridging: a temporary support for deteriorating heart transplantation-candidates – methods and results. Thorac Cardiovasc Surg 35 (5): 277–82

    PubMed  CAS  Google Scholar 

  • Laufer G, Laczkovics A, Wollenek G, Schreiner W, Wolner E (1988) Results of orthotopic heart transplantation with and without the use of maintenance steroids. Eur J Cardiothorac Surg 2 (4): 237–43

    Article  PubMed  CAS  Google Scholar 

  • Laufer G, Laczkovics A, Wollenek G, Schreiner W, Kober I, Wolner E (1988) Incidence and severity of acute cardiac allograft rejection with two different low-dose cyclosporine maintenance protocols. Ann Thorac Surg 46 (4): 382–8

    Article  PubMed  CAS  Google Scholar 

  • Wollenek G, Laufer G, Laczkovics A, Buxbaum P, Kober I (1989) Comparison of a monoclonal anti-T cell antibody vs ATG as prophylaxis after heart transplantation. Transplant Proc 21 (1 Pt 3): 2499–501

    PubMed  CAS  Google Scholar 

  • Laufer G, Laczkovics A, Wollenek G, Schreiner W, Sochor H, Holzinger C, et al (1989) Impacts of low-dose steroids and prophylactic monoclonal versus polyclonal antibodies on acute rejection in cyclosporine- and azathioprine-immunosuppressed cardiac allografts. J Heart Transplant 8 (3): 253–61

    PubMed  CAS  Google Scholar 

  • Laufer G, Miholic J, Laczkovics A, Wollenek G, Holzinger C, Hajek-Rosenmeier A, et al (1989) Independent risk factors predicting acute graft rejection in cardiac transplant recipients treated by triple drug immunosuppression. J Thorac Cardiovasc Surg 98 (6): 1113–21

    PubMed  CAS  Google Scholar 

  • Laufer G, Laczkovics A, Wollenek G, Buxbaum P, Seitelberger R, Holzinger C, et al (1991) The progression of mild acute cardiac rejection evaluated by risk factor analysis. The impact of maintenance steroids and serum creatinine. Transplantation 51 (1): 184–9

    Article  PubMed  CAS  Google Scholar 

  • Laufer G, Laczkovics A, Wollenek G, Buxbaum P, Graninger W, Holzinger C, et al (1989) Infectious complications in heart transplant recipients with combined low dose cyclosporine, azathioprine and prednisolone (triple drug) immunosuppression. Transplant Proc 21 (1 Pt 3): 2508–11

    PubMed  CAS  Google Scholar 

  • Havel MP, Laczkovics AM, Wolner E, Kurz RW, Popow-Kraupp T (1989) Prophylactic use of hyperimmunoglobulin for cytomegalovirus infection in heart transplantation. Clin Ther 11 (4): 472–8

    PubMed  CAS  Google Scholar 

  • Holzinger C, Buxbaum P, Laczkovics A, Domanig E, Wolner E (1990) Infections in organ transplantations. Zentralbl Chir 115 (17): 1091–9

    PubMed  CAS  Google Scholar 

  • Havel M, Teufelsbauer H, Laczkovics A, Kurz R, Wolner E (1990) Cytomegalovirus hyperimmunoglobulin prophylaxis in the prevention of cytomegalovirus infection in immunosuppressed heart transplant patients. Transplant Proc 22 (4): 1805–6

    PubMed  CAS  Google Scholar 

  • Bunzel B, Grundböck A, Laczkovics A, Holzinger C (1990) Surgical success following heart transplantation in relation to preoperative status. Wien Klin Wochenschr 102 (13): 375–8

    PubMed  CAS  Google Scholar 

  • Bunzel B, Grundböck A, Laczkovics A, Holzinger C, Teufelsbauer H (1991) Quality of life after orthotopic heart transplantation. J Heart Lung Transplant 10 (3): 455–9

    PubMed  CAS  Google Scholar 

  • Hölzel WG, Havel M, Laczkovics A, Müller MM (1988) Diagnostic validity of multivariate combinations of biochemical analytes as markers for rejection and infection in the follow-up of patients with heart transplants. J Clin Chem Clin Biochem 26 (11): 667–71

    PubMed  Google Scholar 

  • Havel M, Laczkovics A, Teufelsbauer H, Müller MM, Wolner E (1989) Neopterin as a new marker to detect acute rejection after heart transplantation. J Heart Transplant 8 (2): 167–70

    PubMed  CAS  Google Scholar 

  • Teufelsbauer H, Prischl FC, Havel M, Holzinger C, Lion T, Schwarzmeier JD, et al (1989) Beta 2-microglobulin. A reliable parameter for differentiating between graft rejection and severe infection after cardiac transplantation. Circulation 80 (6): 1681–8

    PubMed  CAS  Google Scholar 

  • Holzinger C, Zuckermann A, Laczkovics A, Seitelberger R, Laufer G, Andert S, Kink F, Horvart R, Wolner E (1991) Monitoring of mononuclear cell subsets isolated from the coronary sinus and the right atrium in patients after heart allograft transplantation. J Thorac Cardiovasc Surg 102 (2): 215–22; discussion 223

    PubMed  CAS  Google Scholar 

  • Schreiner W, Lahoda R, Laufer G, Premauer W, Merksa F, Zahradnik D, et al (1990) Analysis of the ECG in diagnosis of graft rejection following heart Transplantation. Biomed Tech (Berl) 35 [Suppl 2]: 75–6

    Article  Google Scholar 

  • Heinz G, Ohner T, Laufer G, Gasic S, Laczkovics A (1990) Clinical and electrophysiologic correlates of sinus node dysfunction after orthotopic heart transplantation. Observations in 42 patients. Chest 97 (4): 890–5

    Article  PubMed  CAS  Google Scholar 

  • Heinz G, Laufer G, Ohner T, Gasic S, Laczkovics A (1990) Analysis of heart rate changes in cardiac transplant recipients related to graft rejection. Am J Cardiol 66 (5): 647–8

    Article  PubMed  CAS  Google Scholar 

  • Heinz G, Ohner T, Laufer G, Gössinger H, Gasic S, Laczkovics A (1991) Demographic and perioperative factors associated with initial and prolonged sinus node dysfunction after orthotopic heart transplantation. The impact of ischemic time. Transplantation 51 (6): 1217–24

    Article  PubMed  CAS  Google Scholar 

  • Schreiner W, Laufer G, Neumann M, Lahoda R, Premauer W, Merksa F, et al (1991) A beat-by-beat analysis of electrocardiograms from cardiac transplant recipients. J Biomed Eng 13 (4): 313–20

    Article  PubMed  CAS  Google Scholar 

  • Grimm M, Grimm G, Zuckermann A, Wieselthaler G, Daneschvar H, Kocher A, et al (1995) Strategies in management of heart transplantation candidates with tachycardic ventricular arrhythmia anamnesis. Wien Klin Wochenschr 107 (16): 479–84

    PubMed  CAS  Google Scholar 

  • Grimm M, Grimm G, Zuckermann A, Wieselthaler G, Feuerstein M, Daneschvar H, et al (1995) ICD therapy in survivors of sudden cardiac death awaiting heart transplantation. Ann Thorac Surg 59 (4): 916–20

    Article  PubMed  CAS  Google Scholar 

  • Grimm M, Wieselthaler G, Avanessian R, Grimm G, Schmidinger H, Schreiner W, et al (1995) The impact of implantable cardioverter-defibrillators on mortality among patients on the waiting list for heart transplantation. J Thorac Cardiovasc Surg 110 (2): 532–9

    Article  PubMed  CAS  Google Scholar 

  • Daneschvar H, Pacher R, Rödler S, Stanek B, Hülsmann M, Grimm M, et al (1996) Acceptance of a pump-driven infusion therapy with prostaglandin E1 as a bridge to heart transplantation. Wien Klin Wochenschr 108 (16): 510–4

    PubMed  CAS  Google Scholar 

  • Pacher R, Stanek B, Hülsmann M, Berger R, Siegel A, Daneschvar H, et al (1997) Prostaglandin E1 – bridge to cardiac transplantation. Technique, dosage, results. Eur Heart J 18 (2): 318–29

    PubMed  CAS  Google Scholar 

  • Stanek B, Sturm B, Frey B, Hülsmann M, Bojic A, Berger R, et al (1999) Bridging to heart transplantation: prostaglandin E1 versus prostacyclin versus dobutamine. J Heart Lung Transplant 18 (4): 358–66

    Article  PubMed  CAS  Google Scholar 

  • Kratochwill C, Schmid S, Koller-Strametz J, Kreiner G, Grabenwöger M, Grimm M, et al (1996) Decrease in pacemaker incidence after orthotopic heart transplantation. Am J Cardiol 77 (9): 779–83

    Article  PubMed  CAS  Google Scholar 

  • Koller-Strametz J, Kratochwill C, Grabenwöger M, Laufer G, Pacher R, Gemeiner N, et al (1997) PR interval adaptation in the denervated transplanted heart. Pacing Clin Electrophysiol 20 (5 Pt 1): 1247–51

    Article  PubMed  CAS  Google Scholar 

  • Heinz G, Kratochwill C, Koller-Strametz J, Kreiner G, Grimm M, Grabenwöger M, et al (1998) Benign prognosis of early sinus node dysfunction after orthotopic cardiac transplantation. Pacing Clin Electrophysiol 21 (2): 422–9

    Article  PubMed  CAS  Google Scholar 

  • Klappacher G, Mehrabi M, Franzen P, Plesch K, Binder M, Haab D, et al (1994) Endomyocardial HLA expression is increased to the same extent in idiopathic and secondary dilated cardiomyopathy. Immunol Lett 41 (1): 59–66

    Article  PubMed  CAS  Google Scholar 

  • Holzinger C, Zuckermann A, Reinwald C, Imhof M, Schöllhammer A, Kramer, et al (1996) Are T cells from healthy heart really only passengers? Characterization of cardiac tissue T cells. Immunol Lett 53 (2–3): 63–7

    Article  PubMed  CAS  Google Scholar 

  • Baumgartner H, Porenta G, Lau YK, Wutte M, Klaar U, Mehrabi M, et al (1998) Assessment of myocardial viability by dobutamine echocardiography, positron emission tomography and thallium-201 SPECT: correlation with histopathology in explanted hearts. J Am Coll Cardiol 32 (6): 1701–8

    Article  PubMed  CAS  Google Scholar 

  • Vogl M, Griesmacher A, Grimm M, Klepetko W, Müller MM (1995) Tissue polypeptide specific antigen for the detection of lymphoproliferative diseases induced by cyclosporin. J Clin Pathol 48 (11): 1039–44

    Article  PubMed  CAS  Google Scholar 

  • Grimm M, Yeganehfar W, Laufer G, Madl C, Kramer L, Eisenhuber E, et al (1996) Cyclosporine may affect improvement of cognitive brain function after successful cardiac transplantation. Circulation 94 (6): 1339–45

    PubMed  CAS  Google Scholar 

  • Griesmacher A, Weigel G, Seebacher G, Mallinger R, Laufer G, Müller MM (1998) Inhibition of inosine monophosphate dehydrogenase activity by the plasma of heart transplant recipients receiving mycophenolate mofetil. Adv Exp Med Biol 431: 537–41

    PubMed  CAS  Google Scholar 

  • Seebacher G, Mallinger R, Laufer G, Grimm M, Griesmacher A, Weigel G, et al (1998) Pharmacokinetics of mycophenolate mofetil in heart transplant recipients. Adv Exp Med Biol 431: 801–3

    PubMed  CAS  Google Scholar 

  • Seebacher G, Weigel G, Griesmacher A, Mallinger R, Zuckermann A, Grimm M, et al (1999) One and a half years of experience with mycophenolate mofetil (Cellcept) in cardiac transplantation: a prospective, randomized study. Transplant Proc 31 (8): 3291–3

    Article  PubMed  CAS  Google Scholar 

  • Müller TF, Vogl M, Neumann MC, Lange H, Grimm M, Müller MM (1998) Noninvasive monitoring using serum amyloid A and serum neopterin in cardiac transplantation. Clin Chim Acta 276 (1): 63–74

    Article  PubMed  Google Scholar 

  • Moidl R, Chevtchik O, Simon P, Grimm M, Wieselthaler G, Ullrich R, et al (1999) Noninvasive monitoring of peak filling rate with acoustic quantification echocardiography accurately detects acute cardiac allograft rejection. J Heart Lung Transplant 18 (3): 194–201

    Article  PubMed  CAS  Google Scholar 

  • Eisen HJ, Hobbs RE, Davis SF, Laufer G, Mancini DM, Renlund DG, et al (1999) Safety, tolerability and efficacy of cyclosporine microemulsion in heart transplant recipients: a randomized, multicenter, double-blind comparison with the oil based formulation of cyclosporine – results at six months after transplantation. Transplantation 68 (5): 663–71

    Article  PubMed  CAS  Google Scholar 

  • Eisen HJ, Hobbs RE, Davis SF, Carrier M, Mancini DM, Smith A, et al (2001) Safety, tolerability, and efficacy of cyclosporine microemulsion in heart transplant recipients: a randomized, multicenter, double-blind comparison with the oil-based formulation of cyclosporine – results at 24 months after transplantation. Transplantation 71 (1): 70–8

    Article  PubMed  CAS  Google Scholar 

  • Grasser B, Iberer F, Schreier G, Kastner P, Schaffellner S, Kniepeiss D, et al (2003) Computerized heart allograft-recipient monitoring: a multicenter study. Transpl Int 16 (4): 225–30

    Article  PubMed  Google Scholar 

  • Eisen HJ, Tuzcu EM, Dorent R, Kobashigawa J, Mancini D, Valantine-von Kaeppler H, et al (2003) Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients. N Engl J Med 349 (9): 847–58

    Article  PubMed  CAS  Google Scholar 

  • Podesser BK, Rinaldi M, Yona NA, Pulpón LA, Villemot JP, Haverich A, et al (2005) Comparison of low and high initial tacrolimus dosing in primary heart transplant recipients: a prospective European multicenter study. Transplantation 79 (1): 65–71

    Article  PubMed  CAS  Google Scholar 

  • Grimm M, Rinaldi M, Yonan NA, Arpesella G, Arizón Del Prado, et al (2006) Superior prevention of acute rejection by tacrolimus vs. cyclosporine in heart transplant recipients – a large European trial. Am J Transplant 6 (6): 1387–97

    Article  PubMed  CAS  Google Scholar 

  • Zuckermann AO, Ofner P, Holzinger C, Grimm M, Mallinger R, Laufer G, et al (2000) Pre- and early postoperative risk factors for death after cardiac transplantation: a single center analysis. Transpl Int 13 (1): 28–34

    PubMed  CAS  Google Scholar 

  • Zuckermann AO, Grimm M, Czerny M, Ofner P, Ullrich R, Ploner M, et al (2000) Improved long-term results with thymoglobuline induction therapy after cardiac transplantation: a comparison of two different rabbit-antithymocyte globulines. Transplantation 69 (9): 1890–8

    Article  PubMed  CAS  Google Scholar 

  • Zuckermann A, Ploner M, Czerny M, Keziban U, Birsan T, Laufer G, et al (2002) Low incidence of graft arteriosclerosis after cardiac transplantation: risk factor analysis for patients with induction therapy. Transplant Proc 34 (5): 1869–71

    Article  PubMed  CAS  Google Scholar 

  • Wexberg P, Pacher R, Rödler S, Kiss K, Beran G, Grimm M, et al (2002) Intimal hyperplasia and coronary flow reserve after heart transplantation: association with big endothelin-1. J Heart Lung Transplant 21 (12): 1257–63

    Article  PubMed  Google Scholar 

  • Kocher AA, Bonaros N, Dunkler D, Ehrlich M, Schlechta B, Zweytick B, et al (2003) Long-term results of CMV hyperimmune globulin prophylaxis in 377 heart transplant recipients. J Heart Lung Transplant 22 (3): 250–7

    Article  PubMed  Google Scholar 

  • Zuckermann A, Dunkler D, Deviatko E, Bodhjalian A, Czerny M, Ankersmit J, et al (2003) Long-term survival (> 10 years) of patients > 60 years with induction therapy after cardiac transplantation. Eur J Cardiothorac Surg 24 (2): 283–91

    Article  PubMed  Google Scholar 

  • Starling RC, Pham M, Valantine H, Miller L, Eisen H, et al (2006) Working Group on Molecular Testing in Cardiac Transplantation. Molecular testing in the management of cardiac transplant recipients: initial clinical experience. J Heart Lung Transplant 25 (12): 1389–95

    Article  PubMed  Google Scholar 

  • Meyer B, Moertl D, Huelsmann M, Kulemann V, Zuckermann A, Grimm M, et al (2006) Heart transplantation provides long-term survival benefit in stable patients experiencing heart failure without reverse left ventricular remodeling. Transplantation 82 (11): 1463–71

    Article  PubMed  Google Scholar 

  • Taghavi S, Zuckermann A, Ankersmit J, Wieselthaler G, Rajek A, Laufer G, et al (2004) Extracorporeal membrane oxygenation is superior to right ventricular assist device for acute right ventricular failure after heart transplantation. Ann Thorac Surg 78 (5): 1644–9

    Article  PubMed  Google Scholar 

  • Aharinejad S, Schäfer R, Hofbauer R, Abraham D, Blumer R, Miksovsky A, et al (2001) Impact of cardiac transplantation on molecular pathology of ET-1, VEGF-C, and mitochondrial metabolism and morphology in dilated versus ischemic cardiomyopathic patients. Transplantation 72 (6): 1043–9

    Article  PubMed  CAS  Google Scholar 

  • Aharinejad S, Abraham D, Paulus P, Zins K, Hofmann M, Michlits W, et al (2008) Colony-stimulating factor-1 transfection of myoblasts improves the repair of failing myocardium following autologous myoblast transplantation. Cardiovasc Res 79 (3): 395–404

    Article  PubMed  CAS  Google Scholar 

  • Aharinejad S, Andrukhova O, Lucas T, Zuckermann A, Wieselthaler G, Wolner E, et al (2008) Programmed cell death in idiopathic dilated cardiomyopathy is mediated by suppression of the apoptosis inhibitor Apollon. Ann Thorac Surg 86 (1): 109–14

    Article  PubMed  Google Scholar 

  • Aharinejad S, Schäfer R, Krenn K, Zuckermann A, Schneider B, Neumann F, et al (2007) Donor myocardial HIF-1alpha is an independent predictor of cardiac allograft dysfunction: a 7-year prospective, exploratory study. Am J Transplant 7 (8): 2012–9

    Article  PubMed  CAS  Google Scholar 

  • Aharinejad S, Krenn K, Paulus P, Schäfer R, Zuckermann A, Grimm M, et al (2005) Differential role of TGF-beta1/bFGF and ET-1 in graft fibrosis in heart failure patients. Am J Transplant 5 (9): 2185–92

    Article  PubMed  CAS  Google Scholar 

  • Valantine H, Zuckermann A (2005) From clinical trials to clinical practice: an overview of Certican (everolimus) in heart transplantation. J Heart Lung Transplant 24 [4 Suppl]: S185–90

    Article  PubMed  Google Scholar 

  • Devyatko E, Zuckermann A, Bohdjalian A, Roedler S, Dunkler D, Grimm M, et al (2006) Activation of the purine salvage pathway in mononuclear cells of cardiac recipients treated with mycophenolate mofetil. Transplantation 82 (1): 113–8

    Article  PubMed  CAS  Google Scholar 

  • Aliabadi AZ, Zuckermann AO, Grimm M (2007) Immunosuppressive therapy in older cardiac transplant patients. Drugs Aging 24 (11): 913–32

    Article  PubMed  CAS  Google Scholar 

  • Rothenburger M, Zuckermann A, Bara C, Hummel M, Strüber M, Hirt, et al (2007) Certican Consensus Study Group. Recommendations for the use of everolimus (Certican) in heart transplantation: results from the second German-Austrian Certican Consensus Conference. J Heart Lung Transplant 26 (4): 305–11

    Article  PubMed  Google Scholar 

  • Chapman JR, Valantine H, Albanell J, Arns WA, Campistol JM, Eisen H, et al (2007) Proliferation signal inhibitors in transplantation: questions at the cutting edge of everolimus therapy. Transplant Proc 39 (10): 2937–50

    Article  PubMed  CAS  Google Scholar 

  • Aliabadi AZ, Pohanka E, Seebacher G, Dunkler D, Kammerstätter D, Wolner E, et al (2008) Development of proteinuria after switch to sirolimus-based immunosuppression in long-term cardiac transplant patients. Am J Transplant 8 (4): 854–61

    Article  PubMed  CAS  Google Scholar 

  • Zuckermann A, Manito N, Epailly E, Fiane A, Bara C, Delgado JF, et al (2008) Multidisciplinary insights on clinical guidance for the use of proliferation signal inhibitors in heart transplantation. J Heart Lung Transplant 27 (2): 141–9

    Article  PubMed  Google Scholar 

  • Devyatko E, Dunkler D, Bohdjalian A, Zuckermann A, Grimm M, Muehlbacher F, et al (2008) Lymphocyte activation and correlation with IMPDH activity under therapy with mycophenolate mofetil. Clin Chim Acta 394 (1–2): 67–71

    Article  PubMed  CAS  Google Scholar 

  • Syeda B, Roedler S, Schukro C, Yahya N, Zuckermann A, Glogar D (2005) Transplant coronary artery disease: incidence, progression and interventional revascularization. Int J Cardiol 104 (3): 269–74

    Article  PubMed  Google Scholar 

  • Ullrich R, Exner M, Schillinger M, Zuckermann A, Raith M, Dunkler D, et al (2005) Microsatellite polymorphism in the heme oxygenase-1 gene promoter and cardiac allograft vasculopathy. J Heart Lung Transplant 24 (10): 1600–5

    Article  PubMed  Google Scholar 

  • Czerny M, Sahin V, Fasching P, Zuckermann A, Zimpfer D, Kilo, et al (2002) The impact of diabetes mellitus at the time of heart transplantation on long-term survival. Diabetologia 45 (11): 1498–508

    Article  PubMed  CAS  Google Scholar 

  • Laufer G, Kocher A, Grabenwoger M, Berlakovich GA, Zuckermann A, Ofner P, et al (1997) Simultaneous heart and kidney transplantation as treatment for end-stage heart and kidney failure. Transplantation 64 (8): 1129–34

    Article  PubMed  CAS  Google Scholar 

  • Gorlitzer M, Ankersmit J, Fiegl N, Meinhart J, Lanzenberger M, Unal K, et al (2005) Is the transpulmonary pressure gradient a predictor for mortality after orthotopic cardiac transplantation? Transpl Int 18 (4): 390–5

    Article  PubMed  Google Scholar 

  • Zimpfer D, Zrunek P, Roethy W, Czerny M, Schima H, Huber L, et al (2007) Left ventricular assist devices decrease fixed pulmonary hypertension in cardiac transplant candidates. J Thorac Cardiovasc Surg 133 (3): 689–95

    Article  PubMed  Google Scholar 

  • Zuckermann A, Kocher A, Simon P, Ofner P, Grimm M, Köck S, et al (1996) Expanding the donor pool in cardiac transplantation by accepting donor hearts > 40 years. Transplant Proc 28(1): 179–80

    PubMed  CAS  Google Scholar 

  • Billingham ME, Cary NR, Hammond ME, et al (1990) A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. The International Society for Heart Transplantation. J Heart Transplant 9 (6): 587–93

    PubMed  CAS  Google Scholar 

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Zuckermann, A., Aliabadi, A., Dunkler, D. et al. Heart transplantation in Vienna: 25 years of experience. Wien Klin Wochenschr 120 (Suppl 2), 3–10 (2008). https://doi.org/10.1007/s00508-008-1042-1

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