Geographical distribution of reference values of fibrinogen degradation products in healthy adults in China

Abstract

To explore the reference values of fibrinogen degradation products (FDP) of healthy adults in different regions of China, determine the relationship between them and geographic factors and determine the geographic distribution of FDP reference value healthy adults in China. The collected FDP reference values of 11,013 healthy adults in 209 Chinese units were firstly determined by spatial autocorrelation to correlate with geographic factors; secondly, using ridge regression analysis and principal component analysis to fit China 2322 FDP reference values of healthy adults in each city, and the selection of the optimal model through comparison; and finally, combined with geostatistical analysis, explore the geographical distribution of FDP reference values of healthy adults in China. The specific distribution of FDP reference values of healthy adults in different regions of China showed a trend of being lower to the north and higher to the south of the Qinling-Huaihe River. If the numerical value of geographical factors in a certain region of China is known, the ridge regression prediction equation can be combined from this: Ŷ = 3.30 − 0.002900X2 − 0.0001400X5 + 0.0001300X6 − 0.009040X6 + 0.0003500X8 − 0.002300X11 + 0.02149X14 − 0.01626X16 ± 0.89 calculates the reference value of FDP for healthy adults in the region and provides a scientific reference for the FDP reference value in different regions of China.

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Correspondence to Miao Ge.

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Zhang, L., Ge, M., Yang, W. et al. Geographical distribution of reference values of fibrinogen degradation products in healthy adults in China. Int J Biometeorol (2021). https://doi.org/10.1007/s00484-021-02082-4

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Keywords

  • Fibrinogen degradation products
  • Spatial autocorrelation
  • Ridge regression analysis
  • Principal component analysis
  • Kriging interpolation
  • Geographical distribution